A metabolic switch favoring glycolysis over aerobic oxidative phosphorylation,termed the“Warburg effect”,is a hallmark of cancer cells[1].Hexokinase(HK)catalyzes the first and irreversible step of glycolysis,thereby...A metabolic switch favoring glycolysis over aerobic oxidative phosphorylation,termed the“Warburg effect”,is a hallmark of cancer cells[1].Hexokinase(HK)catalyzes the first and irreversible step of glycolysis,thereby limiting overall glycolytic activity.Mammals encode five HK family members:HK1-4 and HKDC1(HK domain containing 1).HKDC1 has an exceptionally low glucose affinity and,therefore,low hexokinase activity under physiological conditions[2],raising questions about its function.A recent study indicated that HKDC1 functions as a glucose sensor within the tumor microenvironment[3],and its dysregulated expression has been associated with chronic inflammation[4]and various cancers[5].展开更多
基金supported by the German Research Foundation(DFG)through the individual grant SO1141/10-1,the Research Unit FOR5042“miTarget-The Microbiome as a Target in Inflammatory Bowel Diseases”(project P5)the Excellence Cluster EXS2167“Precision Medicine in Chronic Inflammation”,an intramural grant of the medical faculty of Kiel University(grant no K126408)Felix Sommer and ZMB Young Scientist Award 2021,category doctoral students(grant no F384430)to Lea Järke.
文摘A metabolic switch favoring glycolysis over aerobic oxidative phosphorylation,termed the“Warburg effect”,is a hallmark of cancer cells[1].Hexokinase(HK)catalyzes the first and irreversible step of glycolysis,thereby limiting overall glycolytic activity.Mammals encode five HK family members:HK1-4 and HKDC1(HK domain containing 1).HKDC1 has an exceptionally low glucose affinity and,therefore,low hexokinase activity under physiological conditions[2],raising questions about its function.A recent study indicated that HKDC1 functions as a glucose sensor within the tumor microenvironment[3],and its dysregulated expression has been associated with chronic inflammation[4]and various cancers[5].
