Objective This study aims to investigate the joint associations of sarcopenia and social isolation with mortality risk.Methods Using data from the Chinese Longitudinal Healthy Longevity Survey(CLHLS)and the UK Biobank...Objective This study aims to investigate the joint associations of sarcopenia and social isolation with mortality risk.Methods Using data from the Chinese Longitudinal Healthy Longevity Survey(CLHLS)and the UK Biobank,sarcopenia was diagnosed according to European and Asian Working Groups for Sarcopenia criteria.Social isolation was assessed using standardized questionnaires,including questions on solitude,frequency of social activities,contact with others,and marital status(for the CLHLS only).Results During the follow-up period,8,249 deaths occurred in the CLHLS and 26,670 deaths in the UK Biobank groups.While no significant interaction was observed between sarcopenia and social isolation in predicting all-cause mortality in the CLHLS cohort,the association between social isolation and mortality was stronger among individuals with sarcopenia in the UK Biobank(P-interaction=0.03,relative risk due to interaction:0.23,95%confidence interval[CI]:0.06–0.41).Further joint analyses showed that participants with sarcopenia and high levels of social isolation had the highest mortality risk(hazard ration[HR]:1.99;95%CI:[1.74–2.28]in the CLHLS and 1.69[1.55–1.85]in the UK Biobank)compared to those without either condition.Conclusion The combination of social isolation and sarcopenia synergistically increases the risk of mortality in middle-aged and older adults across diverse populations.展开更多
1.Introduction The coronavirus disease 2019(COVID-19),caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),has swept the globe as a pandemic[1].As of 1 April 2021,there were about 129.5 million confir...1.Introduction The coronavirus disease 2019(COVID-19),caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),has swept the globe as a pandemic[1].As of 1 April 2021,there were about 129.5 million confirmed cases of COVID-19,and 2.8 million deaths attributable to COVID-19[2].While some countries have suppressed COVID-19,most governments worldwide are still mobilizing available resources to contain the spread of SARS-CoV-2 in communities,facilitate COVID-19 treatments in hospitals,expand COVID-19 vaccination,and accelerate drug and vaccine development[3].展开更多
This prospective study aimed to investigate the associations of untreated cholesterol levels and their longitudinal changes,especially low levels,with all-cause and cause-specific mortality in different populations.Pa...This prospective study aimed to investigate the associations of untreated cholesterol levels and their longitudinal changes,especially low levels,with all-cause and cause-specific mortality in different populations.Participants were drawn from two Chinese cohorts and the UK Biobank,excluding those with lipid-lowering medications,coronary heart disease(CHD),stroke,cancer,clinically diagnosed chronic obstructive pulmonary disease,low body mass index(<18.5 kg·m^(-2))at baseline,and deaths within the first two years to minimize reverse causality.Individual cholesterol changes were assessed in a subset who attended the resurvey after over four years.Mortality data were linked to registries,and risks were estimated using Cox proportional hazards models.A total of 163115 Chinese and 317305 UK adults were included(mean age,49-61 years),with 43%,81%,and 44%males in Dongfeng-Tongji,Kailuan,and UK Biobank cohorts,respectively.During a median follow-up of 9.7-12.9 years,9553 and 15760 deaths were documented in the Chinese cohorts and UK Biobank,respectively.After multivariate adjustments,nonlinear relationships were observed between total cholesterol(TC),low-density lipoprotein cholesterol(LDL-C),and non-high-density lipoprotein cholesterol(non-HDL-C)levels and mortality.In both populations,high cholesterol was primarily associated with CHD mortality,while low cholesterol associated with all-cause and cancer mortality(Pnonlinear≤0.0161).The optimal levels for all-cause mortality risk in Chinese adults(TC:200 mg·dL^(-1);LDL-C:130 mg·dL^(-1);non-HDL-C:155 mg·dL^(-1))were lower than those in the UK Biobank but consistent with guideline recommendation.Additionally,decreasing cholesterol levels over four years were associated with higher all-cause and cancer mortality in the Chinese cohorts(P_(nonlinear)≤0.0100).Participants with low TC,LDL-C,or non-HDL-C levels at both baseline and resurvey experienced elevated all-cause mortality risks in both populations,as did those with low/medium baseline levels and>20%reductions over time in Chinese adults.In conclusion,higher TC,LDL-C,and non-HDL-C levels are associated with elevated CHD mortality.Importantly,low and/or longitudinally decreasing cholesterol levels are robustly associated with increased all-cause and cancer mortality,potentially serving as markers of premature death.Regular cholesterol monitoring,with attention to both high and low levels,is recommended to inform guideline updates and clinical strategies.展开更多
Fourier ptychographic microscopy(FPM)is an innovative computational microscopy approach that enables high-throughput imaging with high resolution,wide field of view,and quantitative phase imaging(QPI)by simultaneously...Fourier ptychographic microscopy(FPM)is an innovative computational microscopy approach that enables high-throughput imaging with high resolution,wide field of view,and quantitative phase imaging(QPI)by simultaneously capturing bright-field and dark-field images.However,effectively utilizing dark-field intensity images,including both normally exposed and overexposed data,which contain valuable high-angle illumination information,remains a complex challenge.Successfully extracting and applying this information could significantly enhance phase reconstruction,benefiting processes such as virtual staining and QPI imaging.To address this,we introduce a multi-exposure image fusion(MEIF)framework that optimizes dark-field information by incorporating it into the FPM preprocessing workflow.MEIF increases the data available for reconstruction without requiring changes to the optical setup.We evaluate the framework using both feature-domain and traditional FPM,demonstrating that it achieves substantial improvements in intensity resolution and phase information for biological samples that exceed the performance of conventional high dynamic range(HDR)methods.This image preprocessing-based information-maximization strategy fully leverages existing datasets and offers promising potential to drive advancements in fields such as microscopy,remote sensing,and crystallography.展开更多
Objective To identify whether metabolic status mediates the associations between frailty and mortality and incident cardiovascular disease(CVD),and to assess of interactive or joint relationships between frailty and m...Objective To identify whether metabolic status mediates the associations between frailty and mortality and incident cardiovascular disease(CVD),and to assess of interactive or joint relationships between frailty and metabolic status on these outcomes.Methods In this prospective cohort study of 456,445 UK Biobank participants,frailty was assessed using five phenotype criteria.Metabolic status was scored(0–4)based on central obesity,hypertension,hyperglycemia,and dyslipidemia.Multivariable-adjusted Cox regression models were used to assess the associations between frailty and mortality and incident CVD.Results During a median follow-up of 13.8 years for mortality and 13.6 years for CVD,30,907 deaths(7,467 CVD-related)and 37,115 incident CVD cases occurred.Frailty was associated with higher risks of all-cause mortality(hazard ratio[HR],2.41;95%confidence interval[CI],2.31–2.51),CVD mortality(HR,2.64;95%CI,2.43–2.87),and incident CVD(HR,1.83;95%CI,1.75–1.91),compared with non-frail individuals.Metabolic status mediated 8.7%,16.1%,and 16.4%of these associations,respectively.Frailty and metabolic status interacted multiplicatively for all-cause mortality(P-value for interaction<0.001)and additively for CVD mortality[relative excess risk due to interaction(RERI),1.78;95%CI,0.88–2.68]and incident CVD(RERI,0.60;95%CI,0.33–0.86).Joint exposure to frailty and three to four metabolic disorders conferred 3.34-,6.32-,and 3.30-fold risks of all-cause mortality,CVD mortality,and incident CVD,respectively,compared with metabolically healthy non-frail individuals.Conclusion This study highlights the need for integrated management strategies targeting both frailty and metabolic conditions to mitigate cardiovascular and mortality risks.展开更多
Cardiovascular disease(CVD)and depression and anxiety contribute substantially to the current disease burden worldwide as well as in China.Both depression and anxiety are highly prevalent among patients with CVD.We sy...Cardiovascular disease(CVD)and depression and anxiety contribute substantially to the current disease burden worldwide as well as in China.Both depression and anxiety are highly prevalent among patients with CVD.We systematically reviewed the literature to disentangle the role of depression and anxiety disorders in the onset and prognosis of CVD with an emphasis on cohort studies conducted in the Chinese population.Despite the lack of large-scale prospective studies in China,the available evidence implies that both depression and anxiety are closely associated with the onset and prognosis of CVD,including ischemic heart disease and stroke,in Chinese adults.Putative behavioral and biological mechanisms are implicated in the link between depression/anxiety and CVD.Timely screening and diagnosis followed by proper treatment should be implemented for depression and anxiety in both the general population and patients with CVD.Current standard treatments such as selective serotonin reuptake inhibitors and psychotherapies are recommended for CVD patients with depression,although their efficacy for reducing CVD morbidity and mortality remains uncertain.In conclusion,prospective studies on the link between depression/anxiety and the onset and prognosis of CVD are urgently needed in the Chinese population,and more efforts are warranted to examine the efficacy of depression and anxiety treatments for CVD patients,particularly the integrated care model of including psychiatrists in a multidisciplinary clinical group.展开更多
Type 2 diabetes(T2D)has become a major public health threat across the globe.It has been widely acknowledged that diet plays an important role in the development and management of T2D.Phytoestrogens are polyphenols th...Type 2 diabetes(T2D)has become a major public health threat across the globe.It has been widely acknowledged that diet plays an important role in the development and management of T2D.Phytoestrogens are polyphenols that are structurally similar to endogenous estrogen and have weak estrogenic properties.Emerging evidence from pre-clinical models has suggested that phytoestrogens may have anti-diabetic function via both estrogendependent and estrogen-independent pathways.In the current review,we have summarized the evidence linking two major types of phytoestrogens,isoflavones and lignans,and T2D from epidemiological studies and clinical trials.The cross-sectional and prospective cohort studies have reported inconsistent results,which may due to the large variations in different populations and measurement errors in dietary intakes.Long-term intervention studies using isoflavone supplements have reported potential beneficial effects on glycemic parameters in postmenopausal women,while results from short-term smallsize clinical trials are conflicting.Taken together,the current evidence from different study designs is complex and inconsistent.Although the widespread use of phytoestrogens could not be recommended yet,habitual consumption of phytoestrogens,particularly their intact food sources like soy and whole flaxseed,could be considered as a component of overall healthy dietary pattern for prevention and management of T2D.展开更多
Accumulating epidemiological evidence shows that handgrip strength provides predictive potential in physical,mental,and reproductive health status.However,the associations between handgrip strength and semen character...Accumulating epidemiological evidence shows that handgrip strength provides predictive potential in physical,mental,and reproductive health status.However,the associations between handgrip strength and semen characteristics have not been explored.We recruited 1382 eligible men at the Hubei Province Human Sperm Bank(Wuhan,China)who had their handgrip strength measured at recruitment and provided 6458 repeated semen specimens within a 6-month period.Semen characteristics,including semen volume,sperm motility parameters(immotility,nonprogressive motility,and progressive motility),and sperm concentration,were assessed.Mixed-effect models and restricted cubic spline functions were applied to investigate the relationship of handgrip strength with repeated measurements of semen characteristics.After adjusting for confounding factors,the mixed-effect models revealed that handgrip strength was positively associated with semen volume,sperm concentration,progressive motility,total motility,and total count(all P for trend<0.05).Compared to men in the lowest quartile,those in the highest quartile of handgrip strength had higher semen volume,sperm concentration,progressive motility,total motility,and total count,with measurements of 14.2%(95%confidence interval[CI]:5.9%-23.2%),19.5%(95%CI:7.3%-33.1%),9.5%(95%CI:3.4%-15.9%),8.8%(95%CI:3.2%-14.6%),and 36.4%(95%CI:18.9%-56.5%),respectively.These positive dose-response relationships were further confirmed in restricted cubic splines,where handgrip strength was modeled as a continuous variable.Handgrip strength,as an indicator of muscular function and strength,was positively associated with semen characteristics in a dose-dependentmanner.展开更多
The longitudinal immunologic status of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)-infected patients and its association with the clinical outcome are barely known.Thus,we sought to analyze the tempora...The longitudinal immunologic status of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)-infected patients and its association with the clinical outcome are barely known.Thus,we sought to analyze the temporal profiles of specific antibodies,as well as the associations between the antibodies,proinflammatory cytokines,and survival of patients with coronavirus disease 2019(COVID-19).A total of 1830 laboratory-confirmed COVID-19 cases were recruited.The temporal profiles of the virus,antibodies,and cytokines of the patients until 12 weeks since illness onset were fitted by the locally weighted scatter plot smoothing method.The mediation effect of cytokines on the associations between antibody responses and survival were explored by mediation analysis.Of the 1830 patients,1435 were detectable for SARS-CoV-2,while 395 were positive in specific antibodies only.Of the 1435 patients,2.4%presented seroconversion for neither immunoglobulin G(IgG)nor immunoglobulin M(IgM)during hospitalization.The seropositive rates of IgG and IgM were 29.6%and 48.1%,respectively,in the first week,and plateaued within five weeks.For the patients discharged from the hospital,the IgM decreased slowly,while high levels of IgG were maintained at around 188 AUmL^(-1) for the 12 weeks since illness onset.In contrast,in the patients who subsequently died,IgM declined rapidly and IgG dropped to 87 AUmL^(-1) at the twelfth week.Elevated interleukin-6,interleukin-8,interleukin-10,interleukin-1b,interleukin-2R,and tumor necrosis factor-a levels were observed in the deceased patients in comparison with the discharged patients,and 12.5%of the association between IgG level and mortality risk was mediated by these cytokines.Our study deciphers the temporal profiles of SARS-CoV-2-specific antibodies within the 12 weeks since illness onset and indicates the protective effect of antibody response on survival,which may help to guide prognosis estimation.展开更多
Full-color imaging is essential in digital pathology for accurate tissue analysis.Utilizing advanced optical modulation and phase retrieval algorithms,Fourier ptychographic microscopy(FPM)offers a powerful solution fo...Full-color imaging is essential in digital pathology for accurate tissue analysis.Utilizing advanced optical modulation and phase retrieval algorithms,Fourier ptychographic microscopy(FPM)offers a powerful solution for high-throughput digital pathology,combining high resolution,large field of view,and extended depth of field(DOF).However,the full-color capabilities of FPM are hindered by coherent color artifacts and reduced computational efficiency,which significantly limits its practical applications.Color-transferbased FPM(CFPM)has emerged as a potential solution,theoretically reducing both acquisition and reconstruction threefold time.Yet,existing methods fall short of achieving the desired reconstruction speed and colorization quality.In this study,we report a generalized dual-color-space constrained model for FPM colorization.This model provides a mathematical framework for model-based FPM colorization,enabling a closed-form solution without the need for redundant iterative calculations.Our approach,termed generalized CFPM(gCFPM),achieves colorization within seconds for megapixel-scale images,delivering superior colorization quality in terms of both colorfulness and sharpness,along with an extended DOF.Both simulations and experiments demonstrate that gCFPM surpasses state-of-the-art methods across all evaluated criteria.Our work offers a robust and comprehensive workflow for high-throughput full-color pathological imaging using FPM platforms,laying a solid foundation for future advancements in methodology and engineering.展开更多
基金supported by grants from the National Key Research and Development Program of China(No.2023YFC3606300,No.2022YFC3600300)the National Natural Science Foundation of China(No.82325043)the National Key Research and Development Program of Hubei Province(2022BCA036)。
文摘Objective This study aims to investigate the joint associations of sarcopenia and social isolation with mortality risk.Methods Using data from the Chinese Longitudinal Healthy Longevity Survey(CLHLS)and the UK Biobank,sarcopenia was diagnosed according to European and Asian Working Groups for Sarcopenia criteria.Social isolation was assessed using standardized questionnaires,including questions on solitude,frequency of social activities,contact with others,and marital status(for the CLHLS only).Results During the follow-up period,8,249 deaths occurred in the CLHLS and 26,670 deaths in the UK Biobank groups.While no significant interaction was observed between sarcopenia and social isolation in predicting all-cause mortality in the CLHLS cohort,the association between social isolation and mortality was stronger among individuals with sarcopenia in the UK Biobank(P-interaction=0.03,relative risk due to interaction:0.23,95%confidence interval[CI]:0.06–0.41).Further joint analyses showed that participants with sarcopenia and high levels of social isolation had the highest mortality risk(hazard ration[HR]:1.99;95%CI:[1.74–2.28]in the CLHLS and 1.69[1.55–1.85]in the UK Biobank)compared to those without either condition.Conclusion The combination of social isolation and sarcopenia synergistically increases the risk of mortality in middle-aged and older adults across diverse populations.
基金supported by the National Nature Science Foundation of China(81930124)for An Panthe International Postdoctoral Exchange Fellowship Program of the China Postdoctoral Council(20180062)for Xiong-Fei Pan.
文摘1.Introduction The coronavirus disease 2019(COVID-19),caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),has swept the globe as a pandemic[1].As of 1 April 2021,there were about 129.5 million confirmed cases of COVID-19,and 2.8 million deaths attributable to COVID-19[2].While some countries have suppressed COVID-19,most governments worldwide are still mobilizing available resources to contain the spread of SARS-CoV-2 in communities,facilitate COVID-19 treatments in hospitals,expand COVID-19 vaccination,and accelerate drug and vaccine development[3].
基金supported by the National Natural Science Foundation of China(82021005,82192903,81930092)the Chief Scientist Research Project of Hubei Shizhen Laboratory(HSL2024SX0003)+1 种基金the Fundamental Research Funds for the Central Universities(2019kfyXMBZ015)the 111 Project and the Program for Changjiang Scholars and Innovative Research Team in University.
文摘This prospective study aimed to investigate the associations of untreated cholesterol levels and their longitudinal changes,especially low levels,with all-cause and cause-specific mortality in different populations.Participants were drawn from two Chinese cohorts and the UK Biobank,excluding those with lipid-lowering medications,coronary heart disease(CHD),stroke,cancer,clinically diagnosed chronic obstructive pulmonary disease,low body mass index(<18.5 kg·m^(-2))at baseline,and deaths within the first two years to minimize reverse causality.Individual cholesterol changes were assessed in a subset who attended the resurvey after over four years.Mortality data were linked to registries,and risks were estimated using Cox proportional hazards models.A total of 163115 Chinese and 317305 UK adults were included(mean age,49-61 years),with 43%,81%,and 44%males in Dongfeng-Tongji,Kailuan,and UK Biobank cohorts,respectively.During a median follow-up of 9.7-12.9 years,9553 and 15760 deaths were documented in the Chinese cohorts and UK Biobank,respectively.After multivariate adjustments,nonlinear relationships were observed between total cholesterol(TC),low-density lipoprotein cholesterol(LDL-C),and non-high-density lipoprotein cholesterol(non-HDL-C)levels and mortality.In both populations,high cholesterol was primarily associated with CHD mortality,while low cholesterol associated with all-cause and cancer mortality(Pnonlinear≤0.0161).The optimal levels for all-cause mortality risk in Chinese adults(TC:200 mg·dL^(-1);LDL-C:130 mg·dL^(-1);non-HDL-C:155 mg·dL^(-1))were lower than those in the UK Biobank but consistent with guideline recommendation.Additionally,decreasing cholesterol levels over four years were associated with higher all-cause and cancer mortality in the Chinese cohorts(P_(nonlinear)≤0.0100).Participants with low TC,LDL-C,or non-HDL-C levels at both baseline and resurvey experienced elevated all-cause mortality risks in both populations,as did those with low/medium baseline levels and>20%reductions over time in Chinese adults.In conclusion,higher TC,LDL-C,and non-HDL-C levels are associated with elevated CHD mortality.Importantly,low and/or longitudinally decreasing cholesterol levels are robustly associated with increased all-cause and cancer mortality,potentially serving as markers of premature death.Regular cholesterol monitoring,with attention to both high and low levels,is recommended to inform guideline updates and clinical strategies.
基金supported by the National Natural Science Foundation of China(Grant No.12104500)the Key Research and Development Projects of Shaanxi Province of China(Grant No.2023-YBSF-263).
文摘Fourier ptychographic microscopy(FPM)is an innovative computational microscopy approach that enables high-throughput imaging with high resolution,wide field of view,and quantitative phase imaging(QPI)by simultaneously capturing bright-field and dark-field images.However,effectively utilizing dark-field intensity images,including both normally exposed and overexposed data,which contain valuable high-angle illumination information,remains a complex challenge.Successfully extracting and applying this information could significantly enhance phase reconstruction,benefiting processes such as virtual staining and QPI imaging.To address this,we introduce a multi-exposure image fusion(MEIF)framework that optimizes dark-field information by incorporating it into the FPM preprocessing workflow.MEIF increases the data available for reconstruction without requiring changes to the optical setup.We evaluate the framework using both feature-domain and traditional FPM,demonstrating that it achieves substantial improvements in intensity resolution and phase information for biological samples that exceed the performance of conventional high dynamic range(HDR)methods.This image preprocessing-based information-maximization strategy fully leverages existing datasets and offers promising potential to drive advancements in fields such as microscopy,remote sensing,and crystallography.
基金supported by grants from the National Natural Science Foundation of China(82192902 and 82325043)the National Key R&D Program of China(2023YFC3606300)supported by grants from the National Natural Science Foundation of China(82273623 and 82073554).
文摘Objective To identify whether metabolic status mediates the associations between frailty and mortality and incident cardiovascular disease(CVD),and to assess of interactive or joint relationships between frailty and metabolic status on these outcomes.Methods In this prospective cohort study of 456,445 UK Biobank participants,frailty was assessed using five phenotype criteria.Metabolic status was scored(0–4)based on central obesity,hypertension,hyperglycemia,and dyslipidemia.Multivariable-adjusted Cox regression models were used to assess the associations between frailty and mortality and incident CVD.Results During a median follow-up of 13.8 years for mortality and 13.6 years for CVD,30,907 deaths(7,467 CVD-related)and 37,115 incident CVD cases occurred.Frailty was associated with higher risks of all-cause mortality(hazard ratio[HR],2.41;95%confidence interval[CI],2.31–2.51),CVD mortality(HR,2.64;95%CI,2.43–2.87),and incident CVD(HR,1.83;95%CI,1.75–1.91),compared with non-frail individuals.Metabolic status mediated 8.7%,16.1%,and 16.4%of these associations,respectively.Frailty and metabolic status interacted multiplicatively for all-cause mortality(P-value for interaction<0.001)and additively for CVD mortality[relative excess risk due to interaction(RERI),1.78;95%CI,0.88–2.68]and incident CVD(RERI,0.60;95%CI,0.33–0.86).Joint exposure to frailty and three to four metabolic disorders conferred 3.34-,6.32-,and 3.30-fold risks of all-cause mortality,CVD mortality,and incident CVD,respectively,compared with metabolically healthy non-frail individuals.Conclusion This study highlights the need for integrated management strategies targeting both frailty and metabolic conditions to mitigate cardiovascular and mortality risks.
文摘Cardiovascular disease(CVD)and depression and anxiety contribute substantially to the current disease burden worldwide as well as in China.Both depression and anxiety are highly prevalent among patients with CVD.We systematically reviewed the literature to disentangle the role of depression and anxiety disorders in the onset and prognosis of CVD with an emphasis on cohort studies conducted in the Chinese population.Despite the lack of large-scale prospective studies in China,the available evidence implies that both depression and anxiety are closely associated with the onset and prognosis of CVD,including ischemic heart disease and stroke,in Chinese adults.Putative behavioral and biological mechanisms are implicated in the link between depression/anxiety and CVD.Timely screening and diagnosis followed by proper treatment should be implemented for depression and anxiety in both the general population and patients with CVD.Current standard treatments such as selective serotonin reuptake inhibitors and psychotherapies are recommended for CVD patients with depression,although their efficacy for reducing CVD morbidity and mortality remains uncertain.In conclusion,prospective studies on the link between depression/anxiety and the onset and prognosis of CVD are urgently needed in the Chinese population,and more efforts are warranted to examine the efficacy of depression and anxiety treatments for CVD patients,particularly the integrated care model of including psychiatrists in a multidisciplinary clinical group.
文摘Type 2 diabetes(T2D)has become a major public health threat across the globe.It has been widely acknowledged that diet plays an important role in the development and management of T2D.Phytoestrogens are polyphenols that are structurally similar to endogenous estrogen and have weak estrogenic properties.Emerging evidence from pre-clinical models has suggested that phytoestrogens may have anti-diabetic function via both estrogendependent and estrogen-independent pathways.In the current review,we have summarized the evidence linking two major types of phytoestrogens,isoflavones and lignans,and T2D from epidemiological studies and clinical trials.The cross-sectional and prospective cohort studies have reported inconsistent results,which may due to the large variations in different populations and measurement errors in dietary intakes.Long-term intervention studies using isoflavone supplements have reported potential beneficial effects on glycemic parameters in postmenopausal women,while results from short-term smallsize clinical trials are conflicting.Taken together,the current evidence from different study designs is complex and inconsistent.Although the widespread use of phytoestrogens could not be recommended yet,habitual consumption of phytoestrogens,particularly their intact food sources like soy and whole flaxseed,could be considered as a component of overall healthy dietary pattern for prevention and management of T2D.
基金supported by the National Natural Science Foundation of China(No.81903281)the National Postdoctoral Program for Innovative Talents(No.BX201700087)the Health Commission of Hubei Province Scientific Research Project(No.WJ2019H270).
文摘Accumulating epidemiological evidence shows that handgrip strength provides predictive potential in physical,mental,and reproductive health status.However,the associations between handgrip strength and semen characteristics have not been explored.We recruited 1382 eligible men at the Hubei Province Human Sperm Bank(Wuhan,China)who had their handgrip strength measured at recruitment and provided 6458 repeated semen specimens within a 6-month period.Semen characteristics,including semen volume,sperm motility parameters(immotility,nonprogressive motility,and progressive motility),and sperm concentration,were assessed.Mixed-effect models and restricted cubic spline functions were applied to investigate the relationship of handgrip strength with repeated measurements of semen characteristics.After adjusting for confounding factors,the mixed-effect models revealed that handgrip strength was positively associated with semen volume,sperm concentration,progressive motility,total motility,and total count(all P for trend<0.05).Compared to men in the lowest quartile,those in the highest quartile of handgrip strength had higher semen volume,sperm concentration,progressive motility,total motility,and total count,with measurements of 14.2%(95%confidence interval[CI]:5.9%-23.2%),19.5%(95%CI:7.3%-33.1%),9.5%(95%CI:3.4%-15.9%),8.8%(95%CI:3.2%-14.6%),and 36.4%(95%CI:18.9%-56.5%),respectively.These positive dose-response relationships were further confirmed in restricted cubic splines,where handgrip strength was modeled as a continuous variable.Handgrip strength,as an indicator of muscular function and strength,was positively associated with semen characteristics in a dose-dependentmanner.
基金supported by the National Natural Science Foundation of China(81572017)the National Key Research and Development Plan Program of China(2016YFC1302702 and 2020YFC0860800)+1 种基金the Revitalization Projects after the COVID-19 Plague of the China Association for Science and Technology(20200608CG111311)the Emergency Research Projects for COVID-19 Prevention and Control of the Wuhan Health Commission(EG20M01)。
文摘The longitudinal immunologic status of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)-infected patients and its association with the clinical outcome are barely known.Thus,we sought to analyze the temporal profiles of specific antibodies,as well as the associations between the antibodies,proinflammatory cytokines,and survival of patients with coronavirus disease 2019(COVID-19).A total of 1830 laboratory-confirmed COVID-19 cases were recruited.The temporal profiles of the virus,antibodies,and cytokines of the patients until 12 weeks since illness onset were fitted by the locally weighted scatter plot smoothing method.The mediation effect of cytokines on the associations between antibody responses and survival were explored by mediation analysis.Of the 1830 patients,1435 were detectable for SARS-CoV-2,while 395 were positive in specific antibodies only.Of the 1435 patients,2.4%presented seroconversion for neither immunoglobulin G(IgG)nor immunoglobulin M(IgM)during hospitalization.The seropositive rates of IgG and IgM were 29.6%and 48.1%,respectively,in the first week,and plateaued within five weeks.For the patients discharged from the hospital,the IgM decreased slowly,while high levels of IgG were maintained at around 188 AUmL^(-1) for the 12 weeks since illness onset.In contrast,in the patients who subsequently died,IgM declined rapidly and IgG dropped to 87 AUmL^(-1) at the twelfth week.Elevated interleukin-6,interleukin-8,interleukin-10,interleukin-1b,interleukin-2R,and tumor necrosis factor-a levels were observed in the deceased patients in comparison with the discharged patients,and 12.5%of the association between IgG level and mortality risk was mediated by these cytokines.Our study deciphers the temporal profiles of SARS-CoV-2-specific antibodies within the 12 weeks since illness onset and indicates the protective effect of antibody response on survival,which may help to guide prognosis estimation.
基金supported by the National Natural Science Foundation of China(Grant Nos.12104500 and 82430062)the Key Research and Development Projects of Shaanxi Province(Grant No.2023-YBSF-263),the Shenzhen Engineering Research Centre(Grant No.XMHT20230115004)the Shenzhen Science and Technology Innovation Commission(Grant No.KCXFZ20201221173207022).
文摘Full-color imaging is essential in digital pathology for accurate tissue analysis.Utilizing advanced optical modulation and phase retrieval algorithms,Fourier ptychographic microscopy(FPM)offers a powerful solution for high-throughput digital pathology,combining high resolution,large field of view,and extended depth of field(DOF).However,the full-color capabilities of FPM are hindered by coherent color artifacts and reduced computational efficiency,which significantly limits its practical applications.Color-transferbased FPM(CFPM)has emerged as a potential solution,theoretically reducing both acquisition and reconstruction threefold time.Yet,existing methods fall short of achieving the desired reconstruction speed and colorization quality.In this study,we report a generalized dual-color-space constrained model for FPM colorization.This model provides a mathematical framework for model-based FPM colorization,enabling a closed-form solution without the need for redundant iterative calculations.Our approach,termed generalized CFPM(gCFPM),achieves colorization within seconds for megapixel-scale images,delivering superior colorization quality in terms of both colorfulness and sharpness,along with an extended DOF.Both simulations and experiments demonstrate that gCFPM surpasses state-of-the-art methods across all evaluated criteria.Our work offers a robust and comprehensive workflow for high-throughput full-color pathological imaging using FPM platforms,laying a solid foundation for future advancements in methodology and engineering.
