This work presents the synthesis of Y_(2)O_(3):Eu^(3+),χCa^(2+)(χ=0 mol%,1 mol%,3 mol%,5 mol%,7 mol%,9 mol%,11 mol%)nanophosphors with enhanced photoluminescence properties through a facile solution combustion metho...This work presents the synthesis of Y_(2)O_(3):Eu^(3+),χCa^(2+)(χ=0 mol%,1 mol%,3 mol%,5 mol%,7 mol%,9 mol%,11 mol%)nanophosphors with enhanced photoluminescence properties through a facile solution combustion method for optoelectronic,display,and lighting applications.The X-ray diffraction(XRD)patterns of the proposed nanophosphor reveal its structural properties and crystalline nature.The transmission electron microscope(TEM)results confirm the change in the shape of the particle and aggregation of particles after co-doping with Ca^(2+).Fourier transform infrared spectroscopy(FTIR)and Raman vibrations also confirm the presence of Y-O vibration and subsequently explain the crystalline nature,structural properties,and purity of the samples.All the synthesized nanophosphors samples emit intense red emission at 613 nm(~5D_(0)→~7 F_(2))under excitation with 235,394 and 466 nm wavelengths of Eu^(3+)ions.The photoluminescence(PL)emission spectra excited with 235 nm illustrate the highest emission peak with two other emission peaks excited with 466 and 394 nm that is 1.4 times higher than 466 nm and 1.9 times enhanced by 394 nm wavelength,respectively.The emission intensity of Y_(2)O_(3):Eu^(3+),χCa^(2+)(5 mol%)is increased 8-fold as compared to Eu:Y_(2)O_(3).Doping with Ca^(2+)ions enhances the emission intensity of Eu:Y_(2)O_(3)nanopho sphors due to an increase in energy transfer in Ca^(2+)→Eu^(3+)through asymmetry in the crystal field and by introduction of radiative defect centers through oxygen vacancies in the yttria matrix.It is also observed that the optical band gap and the lifetime of the~5D_(0)level of Eu^(3+)ions in Y_(2)O_(3):Eu^(3+),xCa^(2+)nanophosphor sample gets changed with a doping conce ntration of Ca^(2+)ions.Nanophosphor also reveals high thermal stability and quantum yield as estimating activation energy of 0.25 eV and 81%,respectively.CIE,CCT,and color purity values(>98%)show an improved red-emitting nanophosphor in the warm region of light,which makes this mate rial superior with a specific potential application for UV-based white LEDs with security ink,display devices,and various other optoelectronics devices.展开更多
Triphala is a traditional herbal formulation composed of Terminalia chebula,Terminalia bellirica,and Emblica officinalis,and is rich in polyphenols and tannins.However,the stability and metabolic fate of these compoun...Triphala is a traditional herbal formulation composed of Terminalia chebula,Terminalia bellirica,and Emblica officinalis,and is rich in polyphenols and tannins.However,the stability and metabolic fate of these compounds during gastrointestinal digestion and gut microbial fermentation remain incompletely understood.In the present study,the gastrointestinal stability,microbial biotransformation,and in vitro bioactivity of Triphala were investigated using simulated INFOGEST digestion followed by in vitro colonic fermentation.Substantial microbial metabolism was observed during fermentation,leading to approximately 50-55%degradation of native phe-nolics and the transient formation of urolithins,with maximal levels detected at 24 h.A total of 36 phytocon-stituents were tentatively identified in Triphala churna extract using UPLC-Q-ToF-MS/MS.Selected polyphenols and urolithins as urolithin C,and urolithin B including pyrogallol,gallic acid,epigallocatechin,corilagin,ellagic acid,chebulinic acid,were quantified by UPLC-PDA before and after digestion.Fermentation-induced compo-sitional changes were associated with increased total phenolic content and enhanced antioxidant capacity,as determined by ABTS,FRAP,and DPPH assays.Furthermore,fermented Triphala extracts attenuated palmitic acid/LPS-induced oxidative stress and inflammatory responses in Caco-2 cells,as evidenced by reduced intra-cellular ROS levels,restoration of antioxidant enzyme activities,preservation of epithelial integrity,and sup-pression of pro-inflammatory cytokines(IL-6,TNF-α,and IL-1β).Gut microbiota analysis indicated that fermentation modulated microbial composition,with a reduction in Ruminococcus abundance,no significant change in Bifidobacterium levels,and an increase in Lactobacillus compared to the glucose-supplemented group.Overall,these findings underscore the role of gut microbial biotransformation in influencing the metabolic profile and in vitro bioactivity of Triphala.展开更多
The outward angulation of elbow with supinated forearm is cubitus varus deformity. This deformity is often seen as sequelae of malunited supracondylar fracture of humerus in paediatric age group of 5-8 years. The defo...The outward angulation of elbow with supinated forearm is cubitus varus deformity. This deformity is often seen as sequelae of malunited supracondylar fracture of humerus in paediatric age group of 5-8 years. The deformity is usually non-progressive, but in cases of physeal injury or congenital bony bar formation in the medial condyle of humerus, the deformity is progressive and can he grotesque in appearance. Various types of osteotomies are defined for standard non-progressive cubitus varus deformity, while multiple surgeries are required for progressive deformity until skeletal maturity. In this study we described a novel surgical approach and osteotomy of distal humerus in a 5 years old boy having grotesque progressive cubitus varus deformity, achieving good surgical outcome.展开更多
基金University Grants Commission(UGC),India for providing research fellowshipDST,New Delhi for fellowship under the Women Scientist Scheme-A with file number SR/WOS-A/CS-52/2018Institute of Eminence(IOE),Banaras Hindu University(BHU),India for financial support。
文摘This work presents the synthesis of Y_(2)O_(3):Eu^(3+),χCa^(2+)(χ=0 mol%,1 mol%,3 mol%,5 mol%,7 mol%,9 mol%,11 mol%)nanophosphors with enhanced photoluminescence properties through a facile solution combustion method for optoelectronic,display,and lighting applications.The X-ray diffraction(XRD)patterns of the proposed nanophosphor reveal its structural properties and crystalline nature.The transmission electron microscope(TEM)results confirm the change in the shape of the particle and aggregation of particles after co-doping with Ca^(2+).Fourier transform infrared spectroscopy(FTIR)and Raman vibrations also confirm the presence of Y-O vibration and subsequently explain the crystalline nature,structural properties,and purity of the samples.All the synthesized nanophosphors samples emit intense red emission at 613 nm(~5D_(0)→~7 F_(2))under excitation with 235,394 and 466 nm wavelengths of Eu^(3+)ions.The photoluminescence(PL)emission spectra excited with 235 nm illustrate the highest emission peak with two other emission peaks excited with 466 and 394 nm that is 1.4 times higher than 466 nm and 1.9 times enhanced by 394 nm wavelength,respectively.The emission intensity of Y_(2)O_(3):Eu^(3+),χCa^(2+)(5 mol%)is increased 8-fold as compared to Eu:Y_(2)O_(3).Doping with Ca^(2+)ions enhances the emission intensity of Eu:Y_(2)O_(3)nanopho sphors due to an increase in energy transfer in Ca^(2+)→Eu^(3+)through asymmetry in the crystal field and by introduction of radiative defect centers through oxygen vacancies in the yttria matrix.It is also observed that the optical band gap and the lifetime of the~5D_(0)level of Eu^(3+)ions in Y_(2)O_(3):Eu^(3+),xCa^(2+)nanophosphor sample gets changed with a doping conce ntration of Ca^(2+)ions.Nanophosphor also reveals high thermal stability and quantum yield as estimating activation energy of 0.25 eV and 81%,respectively.CIE,CCT,and color purity values(>98%)show an improved red-emitting nanophosphor in the warm region of light,which makes this mate rial superior with a specific potential application for UV-based white LEDs with security ink,display devices,and various other optoelectronics devices.
文摘Triphala is a traditional herbal formulation composed of Terminalia chebula,Terminalia bellirica,and Emblica officinalis,and is rich in polyphenols and tannins.However,the stability and metabolic fate of these compounds during gastrointestinal digestion and gut microbial fermentation remain incompletely understood.In the present study,the gastrointestinal stability,microbial biotransformation,and in vitro bioactivity of Triphala were investigated using simulated INFOGEST digestion followed by in vitro colonic fermentation.Substantial microbial metabolism was observed during fermentation,leading to approximately 50-55%degradation of native phe-nolics and the transient formation of urolithins,with maximal levels detected at 24 h.A total of 36 phytocon-stituents were tentatively identified in Triphala churna extract using UPLC-Q-ToF-MS/MS.Selected polyphenols and urolithins as urolithin C,and urolithin B including pyrogallol,gallic acid,epigallocatechin,corilagin,ellagic acid,chebulinic acid,were quantified by UPLC-PDA before and after digestion.Fermentation-induced compo-sitional changes were associated with increased total phenolic content and enhanced antioxidant capacity,as determined by ABTS,FRAP,and DPPH assays.Furthermore,fermented Triphala extracts attenuated palmitic acid/LPS-induced oxidative stress and inflammatory responses in Caco-2 cells,as evidenced by reduced intra-cellular ROS levels,restoration of antioxidant enzyme activities,preservation of epithelial integrity,and sup-pression of pro-inflammatory cytokines(IL-6,TNF-α,and IL-1β).Gut microbiota analysis indicated that fermentation modulated microbial composition,with a reduction in Ruminococcus abundance,no significant change in Bifidobacterium levels,and an increase in Lactobacillus compared to the glucose-supplemented group.Overall,these findings underscore the role of gut microbial biotransformation in influencing the metabolic profile and in vitro bioactivity of Triphala.
文摘The outward angulation of elbow with supinated forearm is cubitus varus deformity. This deformity is often seen as sequelae of malunited supracondylar fracture of humerus in paediatric age group of 5-8 years. The deformity is usually non-progressive, but in cases of physeal injury or congenital bony bar formation in the medial condyle of humerus, the deformity is progressive and can he grotesque in appearance. Various types of osteotomies are defined for standard non-progressive cubitus varus deformity, while multiple surgeries are required for progressive deformity until skeletal maturity. In this study we described a novel surgical approach and osteotomy of distal humerus in a 5 years old boy having grotesque progressive cubitus varus deformity, achieving good surgical outcome.
