BACKGROUND Dermatofibrosarcoma protuberans(DFSP)is a rare,low-grade,locally aggressive cutaneous sarcoma.DFSP in the periocular region is exceedingly rare,leading to diagnostic and surgical challenges due to anatomica...BACKGROUND Dermatofibrosarcoma protuberans(DFSP)is a rare,low-grade,locally aggressive cutaneous sarcoma.DFSP in the periocular region is exceedingly rare,leading to diagnostic and surgical challenges due to anatomical constraints in the periocular region.Precise diagnosis is essential to guide appropriate surgical management and prevent recurrence.CASE SUMMARY A 32-year-old female presented with a recurrent tumor in the medial canthus,previously diagnosed as a solitary fibrous tumor in an outside institution.After complete radiological and systemic workup,she was scheduled for a wide local excision followed by reconstruction after getting tumor clear margins on frozen section.Histopathology confirmed DFSP,characterized by storiform spindle cell proliferation,diffuse cluster of differentiation 34 positivity,and signal transducer and activator of transcription 6 negativity.CONCLUSION This case highlights the challenges in the diagnostic and surgical management of DFSP in periocular tumors.Comprehensive surgical excision with appropriate reconstruction is critical for achieving oncological control while preserving aesthetics and function.展开更多
BACKGROUND Oral squamous cell carcinoma(OSCC)poses a major health burden,with frequent late-stage diagnoses and limited prognostic tools.Palmitoyl-protein thioesterase(PPT)1,a lysosomal enzyme,has been implicated in t...BACKGROUND Oral squamous cell carcinoma(OSCC)poses a major health burden,with frequent late-stage diagnoses and limited prognostic tools.Palmitoyl-protein thioesterase(PPT)1,a lysosomal enzyme,has been implicated in tumor biology.This study investigates PPT1 expression in OSCC and its association with clinicopathological features.AIM To evaluate the immunohistochemical expression of PPT1 in OSCC and assess its correlation with patient age,gender,tumor grade,and TNM staging using Hscore quantification.METHODS Immunohistochemistry for PPT1 was performed on 43 histopathologically confirmed OSCC samples.PPT1 expression was quantified using the H-score method(range:0-300).Correlation with clinical parameters was assessed using Spearman’s rank correlation and Kruskal-Wallis test.RESULTS PPT1 expression showed a significant positive correlation with tumor grade(ρ=0.48,P=0.0015),while a weak,nonsignificant negative correlation was noted with patient age(ρ=-0.27,P=0.083).No significant differences were found by gender or tumor stage.Given the small sample size,these findings should be interpreted as preliminary.CONCLUSION PPT1 expression is associated with histological tumor grade in OSCC and may reflect tumor aggressiveness.These initial results highlight the potential of PPT1 as a prognostic biomarker,warranting further validation in larger,multicenter studies.展开更多
文摘BACKGROUND Dermatofibrosarcoma protuberans(DFSP)is a rare,low-grade,locally aggressive cutaneous sarcoma.DFSP in the periocular region is exceedingly rare,leading to diagnostic and surgical challenges due to anatomical constraints in the periocular region.Precise diagnosis is essential to guide appropriate surgical management and prevent recurrence.CASE SUMMARY A 32-year-old female presented with a recurrent tumor in the medial canthus,previously diagnosed as a solitary fibrous tumor in an outside institution.After complete radiological and systemic workup,she was scheduled for a wide local excision followed by reconstruction after getting tumor clear margins on frozen section.Histopathology confirmed DFSP,characterized by storiform spindle cell proliferation,diffuse cluster of differentiation 34 positivity,and signal transducer and activator of transcription 6 negativity.CONCLUSION This case highlights the challenges in the diagnostic and surgical management of DFSP in periocular tumors.Comprehensive surgical excision with appropriate reconstruction is critical for achieving oncological control while preserving aesthetics and function.
文摘BACKGROUND Oral squamous cell carcinoma(OSCC)poses a major health burden,with frequent late-stage diagnoses and limited prognostic tools.Palmitoyl-protein thioesterase(PPT)1,a lysosomal enzyme,has been implicated in tumor biology.This study investigates PPT1 expression in OSCC and its association with clinicopathological features.AIM To evaluate the immunohistochemical expression of PPT1 in OSCC and assess its correlation with patient age,gender,tumor grade,and TNM staging using Hscore quantification.METHODS Immunohistochemistry for PPT1 was performed on 43 histopathologically confirmed OSCC samples.PPT1 expression was quantified using the H-score method(range:0-300).Correlation with clinical parameters was assessed using Spearman’s rank correlation and Kruskal-Wallis test.RESULTS PPT1 expression showed a significant positive correlation with tumor grade(ρ=0.48,P=0.0015),while a weak,nonsignificant negative correlation was noted with patient age(ρ=-0.27,P=0.083).No significant differences were found by gender or tumor stage.Given the small sample size,these findings should be interpreted as preliminary.CONCLUSION PPT1 expression is associated with histological tumor grade in OSCC and may reflect tumor aggressiveness.These initial results highlight the potential of PPT1 as a prognostic biomarker,warranting further validation in larger,multicenter studies.
