Alzheimer＇s disease（AD）：AD,a neurodegenerative disorder and a significant cause of dementia throughout the world mostly affects the older adults but sometimes also seen in young age（early state AD）（Agrawal et a...Alzheimer＇s disease（AD）：AD,a neurodegenerative disorder and a significant cause of dementia throughout the world mostly affects the older adults but sometimes also seen in young age（early state AD）（Agrawal et al.,2017）.展开更多
Chitosan,a natural cationic polysaccharide,is prepared industrially by the hydrolysis of the aminoacetyl groups of chitin,a naturally available marine polymer.Chitosan is a non-toxic,biocompatible and biodegradable po...Chitosan,a natural cationic polysaccharide,is prepared industrially by the hydrolysis of the aminoacetyl groups of chitin,a naturally available marine polymer.Chitosan is a non-toxic,biocompatible and biodegradable polymer and has attracted considerable interest in a wide range of biomedical and pharmaceutical applications including drug delivery,cosmetics,and tissue engineering.The primary hydroxyl and amine groups located on the backbone of chitosan are responsible for the reactivity of the polymer and also act as sites for chemical modification.However,chitosan has certain limitations for use in controlled drug delivery and tissue engineering.These limitations can be overcome by chemical modification.Thus,modified chitosan hydrogels have gained importance in current research on drug delivery and tissue engineering systems.This paper reviews the general properties of chitosan,various methods of modification,and applications of modified chitosan hydrogels.展开更多
The novel envelopedβ-coronavirus SARS-CoV-2(COVID-19)has offered a surprising health challenge all over the world.It develops severe pneumonia leading to acute respiratory distress syndrome(ARDS).Like SARS-COV-2,othe...The novel envelopedβ-coronavirus SARS-CoV-2(COVID-19)has offered a surprising health challenge all over the world.It develops severe pneumonia leading to acute respiratory distress syndrome(ARDS).Like SARS-COV-2,other encapsulated viruses like HIV,HSV,and influenza have also offered a similar challenge in the past.In this regard,many antiviral drugs are being explored with varying degrees of success to combat the associated pathological conditions.Therefore,upon scientific validation&development,these antiviral phytochemicals can attain a futuristic nutraceutical prospect in managing different encapsulated viruses.Houttuynia cordata(HC)is widely reported for activities such as antioxidant,anti-inflammatory,and antiviral properties.The major antiviral bioactive components of HC include essential oils(methyl n-nonyl ketone,lauryl aldehyde,capryl aldehyde),flavonoids(quercetin,rutin,hyperin,quercitrin,isoquercitrin),and alkaloids(norcepharadione B)&polysaccharides.HC can further be explored as a potential nutraceutical agent in the therapy of encapsulated viruses like HIV,HSV,and influenza.The review listed various conventional and green technologies that are being employed to extract potent phytochemicals with diverse activities from the HC.It was indicated that HC also inhibited molecular targets like 3C-like protease(3CLPRO)and RNA-dependent RNA polymerase(RdRp)of COVID-19 by blocking viral RNA synthesis and replication.Antioxidant and hepatoprotective effects of HC have been evident in impeding complications from marketed drugs during antiviral therapies.The use of HC as a nutraceutical is localized within some parts of Southeast Asia.Further technological advances can establish it as a nutraceutical-based functional food against pathogenic enveloped viruses like COVID 19.展开更多
文摘Alzheimer＇s disease（AD）：AD,a neurodegenerative disorder and a significant cause of dementia throughout the world mostly affects the older adults but sometimes also seen in young age（early state AD）（Agrawal et al.,2017）.
文摘Chitosan,a natural cationic polysaccharide,is prepared industrially by the hydrolysis of the aminoacetyl groups of chitin,a naturally available marine polymer.Chitosan is a non-toxic,biocompatible and biodegradable polymer and has attracted considerable interest in a wide range of biomedical and pharmaceutical applications including drug delivery,cosmetics,and tissue engineering.The primary hydroxyl and amine groups located on the backbone of chitosan are responsible for the reactivity of the polymer and also act as sites for chemical modification.However,chitosan has certain limitations for use in controlled drug delivery and tissue engineering.These limitations can be overcome by chemical modification.Thus,modified chitosan hydrogels have gained importance in current research on drug delivery and tissue engineering systems.This paper reviews the general properties of chitosan,various methods of modification,and applications of modified chitosan hydrogels.
基金the NMHS project and funding agencies(DBT&DST)for their generous funding to our institute.
文摘The novel envelopedβ-coronavirus SARS-CoV-2(COVID-19)has offered a surprising health challenge all over the world.It develops severe pneumonia leading to acute respiratory distress syndrome(ARDS).Like SARS-COV-2,other encapsulated viruses like HIV,HSV,and influenza have also offered a similar challenge in the past.In this regard,many antiviral drugs are being explored with varying degrees of success to combat the associated pathological conditions.Therefore,upon scientific validation&development,these antiviral phytochemicals can attain a futuristic nutraceutical prospect in managing different encapsulated viruses.Houttuynia cordata(HC)is widely reported for activities such as antioxidant,anti-inflammatory,and antiviral properties.The major antiviral bioactive components of HC include essential oils(methyl n-nonyl ketone,lauryl aldehyde,capryl aldehyde),flavonoids(quercetin,rutin,hyperin,quercitrin,isoquercitrin),and alkaloids(norcepharadione B)&polysaccharides.HC can further be explored as a potential nutraceutical agent in the therapy of encapsulated viruses like HIV,HSV,and influenza.The review listed various conventional and green technologies that are being employed to extract potent phytochemicals with diverse activities from the HC.It was indicated that HC also inhibited molecular targets like 3C-like protease(3CLPRO)and RNA-dependent RNA polymerase(RdRp)of COVID-19 by blocking viral RNA synthesis and replication.Antioxidant and hepatoprotective effects of HC have been evident in impeding complications from marketed drugs during antiviral therapies.The use of HC as a nutraceutical is localized within some parts of Southeast Asia.Further technological advances can establish it as a nutraceutical-based functional food against pathogenic enveloped viruses like COVID 19.
