BACKGROUND Listeria monocytogenes(L.monocytogenes)is one of the most important zoonotic bacteria that is transmitted to humans through infected animal products and is the cause of human listeriosis.Pregnant women and ...BACKGROUND Listeria monocytogenes(L.monocytogenes)is one of the most important zoonotic bacteria that is transmitted to humans through infected animal products and is the cause of human listeriosis.Pregnant women and immunocompromised patients are more susceptible to the bacterium than healthy people.Recent studies have reported extensive evidence on the role of L.monocytogenes infection and the risk of spontaneous abortion.AIM To evaluate the possible connection with L.monocytogenes in the risk of spontaneous abortion in pregnancy.METHODS We conducted a systematic literature review using several databases to search the relevant case-control studies on the association between L.monocytogenes infection and spontaneous abortion.Finally,the impact of infection with L.monocytogenes and risk of spontaneous abortion was assessed via odds ratio at corresponding 95%confidence intervals.RESULTS In the present study,we evaluated the data of 4059 pregnant women who had a spontaneous abortion,and interestingly their colonization rate of L.monocytogenes was about 20.5%.CONCLUSION Therefore,based on statistical analysis,we found that there is a significant relationship between the infection with L.monocytogenes and spontaneous abortion.展开更多
BACKGROUND Psoriasis is one of the most common chronic systemic diseases,mainly appearing as lesions on the skin and joints,and is associated with a high mortality due to a lack of standard treatment.The exact mechani...BACKGROUND Psoriasis is one of the most common chronic systemic diseases,mainly appearing as lesions on the skin and joints,and is associated with a high mortality due to a lack of standard treatment.The exact mechanism of this disease is not fully understood,but the inflammatory response and dysregulation of the immune system are the most important molecular processes that trigger this disease.The skin microflora is one of the main factors involved in inducing,maturing,and dysregulating the immune system,which may underly the development of psoriasis.AIM To determine the impact of Streptococcus pyogenes(S.pyogenes)infection and susceptibility to psoriasis using available case-control studies.METHODS In this study,we conducted a comprehensive literature search using PubMed,Scopus,Web of science,and Google scholar databases to obtain all available relevant studies on the association between S.pyogenes and psoriasis.We pooled the data using Comprehensive Meta-analysis software to investigate the role of S.pyogenes infection in the development of psoriasis.The probable connection between S.pyogenes and susceptibility to psoriasis was assessed using the odds ratio(OR)with corresponding 95%confidence intervals(CIs).RESULTS Data from 781 cases were evaluated in this study.Our results showed that the rate of infection with S.pyogenes in psoriatic patients and healthy individuals was 33.4%(95%CI:27.8-39.6)and 16.2%(95%CI:9.7-25.9),respectively.S.pyogenes infection significantly increased the risk of psoriasis(OR:6.58;95%CI:3.64-11.87;P=0.001).CONCLUSION S.pyogenes infection can significantly increase the risk of psoriasis.Thus,infection with S.pyogenes is a risk factor for the initiation and development of psoriatic events.展开更多
文摘BACKGROUND Listeria monocytogenes(L.monocytogenes)is one of the most important zoonotic bacteria that is transmitted to humans through infected animal products and is the cause of human listeriosis.Pregnant women and immunocompromised patients are more susceptible to the bacterium than healthy people.Recent studies have reported extensive evidence on the role of L.monocytogenes infection and the risk of spontaneous abortion.AIM To evaluate the possible connection with L.monocytogenes in the risk of spontaneous abortion in pregnancy.METHODS We conducted a systematic literature review using several databases to search the relevant case-control studies on the association between L.monocytogenes infection and spontaneous abortion.Finally,the impact of infection with L.monocytogenes and risk of spontaneous abortion was assessed via odds ratio at corresponding 95%confidence intervals.RESULTS In the present study,we evaluated the data of 4059 pregnant women who had a spontaneous abortion,and interestingly their colonization rate of L.monocytogenes was about 20.5%.CONCLUSION Therefore,based on statistical analysis,we found that there is a significant relationship between the infection with L.monocytogenes and spontaneous abortion.
文摘BACKGROUND Psoriasis is one of the most common chronic systemic diseases,mainly appearing as lesions on the skin and joints,and is associated with a high mortality due to a lack of standard treatment.The exact mechanism of this disease is not fully understood,but the inflammatory response and dysregulation of the immune system are the most important molecular processes that trigger this disease.The skin microflora is one of the main factors involved in inducing,maturing,and dysregulating the immune system,which may underly the development of psoriasis.AIM To determine the impact of Streptococcus pyogenes(S.pyogenes)infection and susceptibility to psoriasis using available case-control studies.METHODS In this study,we conducted a comprehensive literature search using PubMed,Scopus,Web of science,and Google scholar databases to obtain all available relevant studies on the association between S.pyogenes and psoriasis.We pooled the data using Comprehensive Meta-analysis software to investigate the role of S.pyogenes infection in the development of psoriasis.The probable connection between S.pyogenes and susceptibility to psoriasis was assessed using the odds ratio(OR)with corresponding 95%confidence intervals(CIs).RESULTS Data from 781 cases were evaluated in this study.Our results showed that the rate of infection with S.pyogenes in psoriatic patients and healthy individuals was 33.4%(95%CI:27.8-39.6)and 16.2%(95%CI:9.7-25.9),respectively.S.pyogenes infection significantly increased the risk of psoriasis(OR:6.58;95%CI:3.64-11.87;P=0.001).CONCLUSION S.pyogenes infection can significantly increase the risk of psoriasis.Thus,infection with S.pyogenes is a risk factor for the initiation and development of psoriatic events.
