<b style="line-height:1.5;"><span style="font-family:Verdana;">Objective:</span></b><span style="font-family:'';line-height:1.5;"><span style=&quo...<b style="line-height:1.5;"><span style="font-family:Verdana;">Objective:</span></b><span style="font-family:'';line-height:1.5;"><span style="font-family:Verdana;"> To evaluate the prevalence of spinal infection in a hospital located in the eastern region of Saudi Arabia through a retrospective review and to identify the associated etiological agents in terms of clinical picture, treatment, and outcomes. </span><b><span style="font-family:Verdana;">Design: </span></b><span style="font-family:Verdana;">Retrospective cross-sectional study. </span><b><span style="font-family:Verdana;">Setting:</span></b><span style="font-family:Verdana;"> Single hospital in Dhahran, Saudi Arabia. </span><b><span style="font-family:Verdana;">Patients:</span></b><span style="font-family:Verdana;"> Patients with any type of spinal infection and/or who had undergone neurosurgical intervention for spinal infection between January 2006 and December 2018. </span><b><span style="font-family:Verdana;">Methods:</span></b><span style="font-family:Verdana;"> We collected data on all patients with an established diagnosis of spinal infection from January 2006 to December 2018 in the King Fahad Military Medical Complex in Dhahran, Saudi Arabia. A validated and structured checklist was used for data collection. Spinal infection diagnosis was based on the clinical manifestation, microbiological evidence, radiological findings, and antimicrobial therapy response. </span><b><span style="font-family:Verdana;">Results:</span></b><span style="font-family:Verdana;"> Seventeen patients were included in this study, and their mean age was 54.93 years. Twelve of the patients were male and four were female. The approximate time from symptom onset to diagnosis was 2</span></span><span style="line-height:1.5;font-family:Verdana;"> - </span><span style="line-height:1.5;font-family:Verdana;">6 months. Most of the patients experienced back pain, with lumbosacral spondylitis being the most commonly cited type (61.11%), followed </span><span style="line-height:1.5;font-family:Verdana;">by thoracolumbar spondylodiscitis (25%) and cervical spondylodiscitis (6.25%). The most frequently isolated organism was </span><i style="font-family:'';line-height:1.5;"><span style="font-family:Verdana;">Mycobacterium tuberculosis</span></i><span style="line-height:1.5;font-family:Verdana;"> (8 patients, 50%), followed by extended-spectrum beta lactamase (ESBL)-producing </span><i style="font-family:'';line-height:1.5;"><span style="font-family:Verdana;">Escherichia coli</span></i><span style="line-height:1.5;font-family:Verdana;"> (4 patients, 25%), </span><i style="font-family:'';line-height:1.5;"><span style="font-family:Verdana;">Brucella</span></i><span style="line-height:1.5;font-family:Verdana;"> spp (3 patients, 18.75%), </span><i style="font-family:'';line-height:1.5;"><span style="font-family:Verdana;">Staphylococcus aureus</span></i><span style="line-height:1.5;font-family:Verdana;"> (1 patient, 6.25%), and </span><i style="font-family:'';line-height:1.5;"><span style="font-family:Verdana;">Quambalaria cyanescens</span></i><span style="line-height:1.5;font-family:Verdana;"> (1 patient, 6.25%). Totally, in 50% of the patients with thoracolumbar and lumbosacra site involvement, tuberculosis spondylodiscitis was observed, while another 50% of the cases showed complications associated with paravertebral abscess that required surgical drainage. </span><b style="font-family:'';line-height:1.5;"><span style="font-family:Verdana;">Conclusion:</span></b><span style="font-family:'';line-height:1.5;"> </span><i style="font-family:'';line-height:1.5;"><span style="font-family:Verdana;">M. tuberculosis</span></i><span style="line-height:1.5;font-family:Verdana;"> was found to be the major cause of infectious spondylodiscitis. Additionally, </span><i style="font-family:'';line-height:1.5;"><span style="font-family:Verdana;">Quambalaria cyanescens</span></i><span style="line-height:1.5;font-family:Verdana;"> was isolated;this is the second reported case of the organism being isolated and the first associated with spinal infection.展开更多
文摘<b style="line-height:1.5;"><span style="font-family:Verdana;">Objective:</span></b><span style="font-family:'';line-height:1.5;"><span style="font-family:Verdana;"> To evaluate the prevalence of spinal infection in a hospital located in the eastern region of Saudi Arabia through a retrospective review and to identify the associated etiological agents in terms of clinical picture, treatment, and outcomes. </span><b><span style="font-family:Verdana;">Design: </span></b><span style="font-family:Verdana;">Retrospective cross-sectional study. </span><b><span style="font-family:Verdana;">Setting:</span></b><span style="font-family:Verdana;"> Single hospital in Dhahran, Saudi Arabia. </span><b><span style="font-family:Verdana;">Patients:</span></b><span style="font-family:Verdana;"> Patients with any type of spinal infection and/or who had undergone neurosurgical intervention for spinal infection between January 2006 and December 2018. </span><b><span style="font-family:Verdana;">Methods:</span></b><span style="font-family:Verdana;"> We collected data on all patients with an established diagnosis of spinal infection from January 2006 to December 2018 in the King Fahad Military Medical Complex in Dhahran, Saudi Arabia. A validated and structured checklist was used for data collection. Spinal infection diagnosis was based on the clinical manifestation, microbiological evidence, radiological findings, and antimicrobial therapy response. </span><b><span style="font-family:Verdana;">Results:</span></b><span style="font-family:Verdana;"> Seventeen patients were included in this study, and their mean age was 54.93 years. Twelve of the patients were male and four were female. The approximate time from symptom onset to diagnosis was 2</span></span><span style="line-height:1.5;font-family:Verdana;"> - </span><span style="line-height:1.5;font-family:Verdana;">6 months. Most of the patients experienced back pain, with lumbosacral spondylitis being the most commonly cited type (61.11%), followed </span><span style="line-height:1.5;font-family:Verdana;">by thoracolumbar spondylodiscitis (25%) and cervical spondylodiscitis (6.25%). The most frequently isolated organism was </span><i style="font-family:'';line-height:1.5;"><span style="font-family:Verdana;">Mycobacterium tuberculosis</span></i><span style="line-height:1.5;font-family:Verdana;"> (8 patients, 50%), followed by extended-spectrum beta lactamase (ESBL)-producing </span><i style="font-family:'';line-height:1.5;"><span style="font-family:Verdana;">Escherichia coli</span></i><span style="line-height:1.5;font-family:Verdana;"> (4 patients, 25%), </span><i style="font-family:'';line-height:1.5;"><span style="font-family:Verdana;">Brucella</span></i><span style="line-height:1.5;font-family:Verdana;"> spp (3 patients, 18.75%), </span><i style="font-family:'';line-height:1.5;"><span style="font-family:Verdana;">Staphylococcus aureus</span></i><span style="line-height:1.5;font-family:Verdana;"> (1 patient, 6.25%), and </span><i style="font-family:'';line-height:1.5;"><span style="font-family:Verdana;">Quambalaria cyanescens</span></i><span style="line-height:1.5;font-family:Verdana;"> (1 patient, 6.25%). Totally, in 50% of the patients with thoracolumbar and lumbosacra site involvement, tuberculosis spondylodiscitis was observed, while another 50% of the cases showed complications associated with paravertebral abscess that required surgical drainage. </span><b style="font-family:'';line-height:1.5;"><span style="font-family:Verdana;">Conclusion:</span></b><span style="font-family:'';line-height:1.5;"> </span><i style="font-family:'';line-height:1.5;"><span style="font-family:Verdana;">M. tuberculosis</span></i><span style="line-height:1.5;font-family:Verdana;"> was found to be the major cause of infectious spondylodiscitis. Additionally, </span><i style="font-family:'';line-height:1.5;"><span style="font-family:Verdana;">Quambalaria cyanescens</span></i><span style="line-height:1.5;font-family:Verdana;"> was isolated;this is the second reported case of the organism being isolated and the first associated with spinal infection.
