<strong>Objective:</strong><span style="font-family:Verdana;"> Complete resectability of all visualized tumor implants at debulking surgery for advanced epithelial ovarian cancer is confirm...<strong>Objective:</strong><span style="font-family:Verdana;"> Complete resectability of all visualized tumor implants at debulking surgery for advanced epithelial ovarian cancer is confirmed to be the s</span><span style="font-family:""><span style="font-family:Verdana;">ingle most important prognostic factor. This study aims</span><b> </b><span style="font-family:Verdana;">to develop </span><span style="font-family:Verdana;">preoperative</span><span style="font-family:Verdana;"> predicting score based on clinical, biological, and radiological criteria of epithelial ovarian cancer to assess the feasibility of complete cytoreduction. </span><b><span style="font-family:Verdana;">Study Design: </span></b><span style="font-family:Verdana;">A retrospective record-based study. </span><b><span style="font-family:Verdana;">Patients and Methods: </span></b><span style="font-family:Verdana;">The study was conducted upon 50 consecutive patients managed for epithelial ovarian cancer with FIGO stage III. Patients’ data were collected from records of the Gyne-Oncology Clinic of El Shatby University Maternity Hospital affiliated </span><span style="font-family:Verdana;">to</span><span style="font-family:Verdana;"> Alexandria University. </span><b><span style="font-family:Verdana;">Results:</span></b></span><span style="font-family:""> </span><span style="font-family:""><span style="font-family:Verdana;">Many parameters were significantly associated with completeness of resectability in univariate analysis;including age, BMI, CA125, albumin, pre-albumin, PCI, mesenteric, and right copula of diaphragm affection by CT scan (</span><span style="font-family:Verdana;">p value</span><span style="font-family:Verdana;"> < 0</span></span><span style="font-family:Verdana;">.</span><span style="font-family:Verdana;">05). A 100-point predictability score was developed, 10 for BMI ≥</span><span style="font-family:""> </span><span style="font-family:""><span style="font-family:Verdana;">35 kg/m</span><sup><span style="font-family:Verdana;">2</span></sup><span style="font-family:Verdana;">, 25 </span><span style="font-family:Verdana;">point</span></span><span style="font-family:Verdana;">s</span><span style="font-family:""><span style="font-family:Verdana;"> for Pre albumin < 14.5 mg/dl, 35 </span><span style="font-family:Verdana;">point</span></span><span style="font-family:Verdana;">s</span><span style="font-family:""><span style="font-family:Verdana;"> for mesenteric affection, and 30 </span><span style="font-family:Verdana;">point</span></span><span style="font-family:Verdana;">s</span><span style="font-family:""><span style="font-family:Verdana;"> for </span><span style="font-family:Verdana;">affection</span><span style="font-family:Verdana;"> of Rt. </span><span style="font-family:Verdana;">copula</span><span style="font-family:Verdana;"> of </span><span style="font-family:Verdana;">diaphragm</span><span style="font-family:Verdana;">. The overall accuracy of the score was 92%. </span><b><span style="font-family:Verdana;">Conclusion:</span></b><span style="font-family:Verdana;"> In advanced ovarian cancer, pre-operative predicting score (including clinical, biological, and radiological criteria) can be used as a roadmap for </span><span style="font-family:Verdana;">prediction</span><span style="font-family:Verdana;"> of </span><span style="font-family:Verdana;">feasibility</span><span style="font-family:Verdana;"> of complete resectability. However, more research is needed on larger sample sizes.</span></span>展开更多
文摘<strong>Objective:</strong><span style="font-family:Verdana;"> Complete resectability of all visualized tumor implants at debulking surgery for advanced epithelial ovarian cancer is confirmed to be the s</span><span style="font-family:""><span style="font-family:Verdana;">ingle most important prognostic factor. This study aims</span><b> </b><span style="font-family:Verdana;">to develop </span><span style="font-family:Verdana;">preoperative</span><span style="font-family:Verdana;"> predicting score based on clinical, biological, and radiological criteria of epithelial ovarian cancer to assess the feasibility of complete cytoreduction. </span><b><span style="font-family:Verdana;">Study Design: </span></b><span style="font-family:Verdana;">A retrospective record-based study. </span><b><span style="font-family:Verdana;">Patients and Methods: </span></b><span style="font-family:Verdana;">The study was conducted upon 50 consecutive patients managed for epithelial ovarian cancer with FIGO stage III. Patients’ data were collected from records of the Gyne-Oncology Clinic of El Shatby University Maternity Hospital affiliated </span><span style="font-family:Verdana;">to</span><span style="font-family:Verdana;"> Alexandria University. </span><b><span style="font-family:Verdana;">Results:</span></b></span><span style="font-family:""> </span><span style="font-family:""><span style="font-family:Verdana;">Many parameters were significantly associated with completeness of resectability in univariate analysis;including age, BMI, CA125, albumin, pre-albumin, PCI, mesenteric, and right copula of diaphragm affection by CT scan (</span><span style="font-family:Verdana;">p value</span><span style="font-family:Verdana;"> < 0</span></span><span style="font-family:Verdana;">.</span><span style="font-family:Verdana;">05). A 100-point predictability score was developed, 10 for BMI ≥</span><span style="font-family:""> </span><span style="font-family:""><span style="font-family:Verdana;">35 kg/m</span><sup><span style="font-family:Verdana;">2</span></sup><span style="font-family:Verdana;">, 25 </span><span style="font-family:Verdana;">point</span></span><span style="font-family:Verdana;">s</span><span style="font-family:""><span style="font-family:Verdana;"> for Pre albumin < 14.5 mg/dl, 35 </span><span style="font-family:Verdana;">point</span></span><span style="font-family:Verdana;">s</span><span style="font-family:""><span style="font-family:Verdana;"> for mesenteric affection, and 30 </span><span style="font-family:Verdana;">point</span></span><span style="font-family:Verdana;">s</span><span style="font-family:""><span style="font-family:Verdana;"> for </span><span style="font-family:Verdana;">affection</span><span style="font-family:Verdana;"> of Rt. </span><span style="font-family:Verdana;">copula</span><span style="font-family:Verdana;"> of </span><span style="font-family:Verdana;">diaphragm</span><span style="font-family:Verdana;">. The overall accuracy of the score was 92%. </span><b><span style="font-family:Verdana;">Conclusion:</span></b><span style="font-family:Verdana;"> In advanced ovarian cancer, pre-operative predicting score (including clinical, biological, and radiological criteria) can be used as a roadmap for </span><span style="font-family:Verdana;">prediction</span><span style="font-family:Verdana;"> of </span><span style="font-family:Verdana;">feasibility</span><span style="font-family:Verdana;"> of complete resectability. However, more research is needed on larger sample sizes.</span></span>
