Background:Recent evidence suggests continuous bouts of physical activity(PA)are associated with longevity.We hypothesized the risk of mortality would be lower when the most active minutes of the day were in a continu...Background:Recent evidence suggests continuous bouts of physical activity(PA)are associated with longevity.We hypothesized the risk of mortality would be lower when the most active minutes of the day were in a continuous bout.Methods:PA was assessed using accelerometery in UK Biobank participants.The intensity of the most active continuous(MXCONT)and accumulated(MX)X min of the day,and their ratio(MXRATIO=MXCONT/MX),were determined.MXRATIO indicates how the most active minutes of the day are accumulated,ranging from a single continuous bout through to sporadic accumulation spread across the day.Durations(X)considered ranged from 1 to 20 min.The outcome was mortality.Results:In total,94,541 participants(56.5% female)were included.Over a median(interquartile range)follow-up of 6.9(6.3,7.4)years,2649(2.8%)deaths occurred.Intensity moderated the association between how the most active minutes of the day were accumulated and mortality risk,expressed relative to sporadically accumulated moderate PA.If the most active minutes were of moderate intensity,the risk of mortality was halved for continuous compared to sporadic accumulation,irrespective of duration;if the most active minutes were of vigorous intensity,a continuous bout was associated with the lowest risk for durations under 5 min(e.g.,3 min:hazard ratio(HR)=0.27,95% confidence interval(95%CI):0.21-0.34),while sporadic accumulation was associated with the lowest risk for durations beyond 5 min(HR=0.11,95%CI:0.08-0.15 for the most active 20 min).Conclusion:Optimal PA patterns for reducing mortality differ by intensity and duration.For moderate-intensity PA,a lower mortality risk may be optimized by prioritizing continuous PA for up to 20 min.However,for vigorous-intensity PA,multiple short bouts(<5 min)may be optimal.This suggests tailored PA recommendations may enhance longevity benefits.展开更多
Device-based measurements are recommended to improve population-based physical activity(PA)surveillance.1,2However,implementation remains challenging due to lack of consensus on analytical methods,and the most widely ...Device-based measurements are recommended to improve population-based physical activity(PA)surveillance.1,2However,implementation remains challenging due to lack of consensus on analytical methods,and the most widely used“generic”(absolute intensity)cut-point approach has limited generalisability to population-level free-living data.Further,current methods generally fail to account for differences in people's physical capacity.展开更多
Background Higher accelerometer-assessed volume and intensity of physical activity(PA)have been associated with a longer life expectancy but can be difficult to translate into recommended doses of PA.We aimed to:(a)im...Background Higher accelerometer-assessed volume and intensity of physical activity(PA)have been associated with a longer life expectancy but can be difficult to translate into recommended doses of PA.We aimed to:(a)improve interpretability by producing UK Biobank age-referenced centiles for PA volume and intensity;(b)inform public-health messaging by examining how adding recommended quantities of moderate and vigorous PA affect PA volume and intensity.Methods 92,480 UK Biobank participants aged 43-80 years with wrist-worn accelerometer data were included.Average acceleration and intensity gradient were derived as proxies for PA volume and intensity.We generated sex-specific centile curves using Generalized Additive Models for Location Scale and Shape(GAMLSS)and modeled the effect of adding moderate(walking)or vigorous(running)activity on the combined change in the volume and intensity centiles(change in PA profile).Results In men,volume was lower as age increased while intensity was lower after age 55;in women,both volume and intensity were lower as age increased.Adding 150 min of moderate PA weekly(5×30 min walking)increased the PA profile by 4 percentage points.Defining moderate PA as brisk walking approximately doubled the increase(9 percentage points)while 75 min of vigorous PA weekly(5×15 min running)trebled the increase(13 percentage points).Conclusion These UK Biobank reference centiles provide a benchmark for interpretation of accelerometer data.Application of our translational methods demonstrate that meeting PA guidelines through shorter duration vigorous activity is more beneficial to the PA profile(volume and intensity)than longer duration moderate activity.展开更多
Background There is a lack of research examining the interplay between objectively measured physical activity volume and intensity with life expectancy.The purpose of the study was to investigate the interplay between...Background There is a lack of research examining the interplay between objectively measured physical activity volume and intensity with life expectancy.The purpose of the study was to investigate the interplay between objectively measured PA volume and intensity profiles with modeled life expectancy in women and men within the UK Biobank cohort study and interpret findings in relation to brisk walking.Methods Individuals from UK Biobank with wrist-worn accelerometer data were included.The average acceleration and intensity gradient were extracted to describe the physical activity volume and intensity profile.Mortality data were obtained from national registries.Adjusted life expectancies were estimated using parametric flexible survival models.Results 40,953(57.1%)women(median age=61.9 years)and 30,820(42.9%)men(63.1 years)were included.Over a median follow-up of 6.9 years,there were 1719(2.4%)deaths(733 in women;986 in men).At 60 years,life expectancy was progressively longer for higher physical activity volume and intensity profiles,reaching 95.6 years in women and 94.5 years in men at the 90th centile for both volume and intensity,corresponding to 3.4 additional years(95%confidence interval(95%CI):2.4-4.4)in women and 4.6 additional years(95%CI:3.6-5.6)in men compared to those at the 10th centiles.An additional 10-min or 30-min daily brisk walk was associated with 0.9(95%CI:0.5-1.3)and 1.4 years(95%CI:0.9-1.9)longer life expectancy,respectively,in inactive women;and 1.4 years(95%CI:1.0-1.8)and 2.5(95%CI:1.9-3.1)in inactive men.Conclusion Higher physical activity volumes were associated with longer life expectancy,with a higher physical activity intensity profile further adding to a longer life.Adding as little as a 10-min brisk walk to daily activity patterns may result in a meaningful benefit to life expectancy.展开更多
基金funded by UK Research and Innovation(research which commenced between October 1,2020-March 31,2021,Grant ref MC_PC_20029April 1,2021-September 31,2022,Grant ref MC_PC_20058)supported by the National Institute for Health Research(NIHR)Leicester Biomedical Research Centre and NIHR Applied Research CollaborationEast Midlands(ARC-EM)。
文摘Background:Recent evidence suggests continuous bouts of physical activity(PA)are associated with longevity.We hypothesized the risk of mortality would be lower when the most active minutes of the day were in a continuous bout.Methods:PA was assessed using accelerometery in UK Biobank participants.The intensity of the most active continuous(MXCONT)and accumulated(MX)X min of the day,and their ratio(MXRATIO=MXCONT/MX),were determined.MXRATIO indicates how the most active minutes of the day are accumulated,ranging from a single continuous bout through to sporadic accumulation spread across the day.Durations(X)considered ranged from 1 to 20 min.The outcome was mortality.Results:In total,94,541 participants(56.5% female)were included.Over a median(interquartile range)follow-up of 6.9(6.3,7.4)years,2649(2.8%)deaths occurred.Intensity moderated the association between how the most active minutes of the day were accumulated and mortality risk,expressed relative to sporadically accumulated moderate PA.If the most active minutes were of moderate intensity,the risk of mortality was halved for continuous compared to sporadic accumulation,irrespective of duration;if the most active minutes were of vigorous intensity,a continuous bout was associated with the lowest risk for durations under 5 min(e.g.,3 min:hazard ratio(HR)=0.27,95% confidence interval(95%CI):0.21-0.34),while sporadic accumulation was associated with the lowest risk for durations beyond 5 min(HR=0.11,95%CI:0.08-0.15 for the most active 20 min).Conclusion:Optimal PA patterns for reducing mortality differ by intensity and duration.For moderate-intensity PA,a lower mortality risk may be optimized by prioritizing continuous PA for up to 20 min.However,for vigorous-intensity PA,multiple short bouts(<5 min)may be optimal.This suggests tailored PA recommendations may enhance longevity benefits.
文摘Device-based measurements are recommended to improve population-based physical activity(PA)surveillance.1,2However,implementation remains challenging due to lack of consensus on analytical methods,and the most widely used“generic”(absolute intensity)cut-point approach has limited generalisability to population-level free-living data.Further,current methods generally fail to account for differences in people's physical capacity.
基金supported by the National Institute for Health Research (NIHR) Leicester Biomedical Research Centre and NIHR Applied Research Collaboration East Midlands (ARC EM, (IS-BRC-1215-20010))funded by the National Institute for Health and Care Research Bristol Biomedical Research Centre (IS-BRC-1215-20011)supported by a UKRI research grant (EP/X042464/1)。
文摘Background Higher accelerometer-assessed volume and intensity of physical activity(PA)have been associated with a longer life expectancy but can be difficult to translate into recommended doses of PA.We aimed to:(a)improve interpretability by producing UK Biobank age-referenced centiles for PA volume and intensity;(b)inform public-health messaging by examining how adding recommended quantities of moderate and vigorous PA affect PA volume and intensity.Methods 92,480 UK Biobank participants aged 43-80 years with wrist-worn accelerometer data were included.Average acceleration and intensity gradient were derived as proxies for PA volume and intensity.We generated sex-specific centile curves using Generalized Additive Models for Location Scale and Shape(GAMLSS)and modeled the effect of adding moderate(walking)or vigorous(running)activity on the combined change in the volume and intensity centiles(change in PA profile).Results In men,volume was lower as age increased while intensity was lower after age 55;in women,both volume and intensity were lower as age increased.Adding 150 min of moderate PA weekly(5×30 min walking)increased the PA profile by 4 percentage points.Defining moderate PA as brisk walking approximately doubled the increase(9 percentage points)while 75 min of vigorous PA weekly(5×15 min running)trebled the increase(13 percentage points).Conclusion These UK Biobank reference centiles provide a benchmark for interpretation of accelerometer data.Application of our translational methods demonstrate that meeting PA guidelines through shorter duration vigorous activity is more beneficial to the PA profile(volume and intensity)than longer duration moderate activity.
基金funded by the National Institute for Health Research (NIHR) Leicester Biomedical Research Centre (BRC)the Applied Research Collaborations East Midlands (ARC-EM)supported by a UKRI project grant (MR/T031816/1)。
文摘Background There is a lack of research examining the interplay between objectively measured physical activity volume and intensity with life expectancy.The purpose of the study was to investigate the interplay between objectively measured PA volume and intensity profiles with modeled life expectancy in women and men within the UK Biobank cohort study and interpret findings in relation to brisk walking.Methods Individuals from UK Biobank with wrist-worn accelerometer data were included.The average acceleration and intensity gradient were extracted to describe the physical activity volume and intensity profile.Mortality data were obtained from national registries.Adjusted life expectancies were estimated using parametric flexible survival models.Results 40,953(57.1%)women(median age=61.9 years)and 30,820(42.9%)men(63.1 years)were included.Over a median follow-up of 6.9 years,there were 1719(2.4%)deaths(733 in women;986 in men).At 60 years,life expectancy was progressively longer for higher physical activity volume and intensity profiles,reaching 95.6 years in women and 94.5 years in men at the 90th centile for both volume and intensity,corresponding to 3.4 additional years(95%confidence interval(95%CI):2.4-4.4)in women and 4.6 additional years(95%CI:3.6-5.6)in men compared to those at the 10th centiles.An additional 10-min or 30-min daily brisk walk was associated with 0.9(95%CI:0.5-1.3)and 1.4 years(95%CI:0.9-1.9)longer life expectancy,respectively,in inactive women;and 1.4 years(95%CI:1.0-1.8)and 2.5(95%CI:1.9-3.1)in inactive men.Conclusion Higher physical activity volumes were associated with longer life expectancy,with a higher physical activity intensity profile further adding to a longer life.Adding as little as a 10-min brisk walk to daily activity patterns may result in a meaningful benefit to life expectancy.
