Nested stromal-epithelial tumor(NSET) is a nonhepatocytic and non-biliary tumor of the liver consisting of nests of epithelial and spindled cells with associated myofibroblastic stroma and variable intra-lesional calc...Nested stromal-epithelial tumor(NSET) is a nonhepatocytic and non-biliary tumor of the liver consisting of nests of epithelial and spindled cells with associated myofibroblastic stroma and variable intra-lesional calcification and ossification, which represents a very rare and challenging disease. Most of the reported cases have been treated with surgery, obtaining a long survival outcome. Here, we report the case of a 31-year-old Caucasian man who underwent surgery at our institution for a large, lobulated, multinodular mass of the right hemi-liver. The histological exam confirmed the diagnosis of NSET. After 6 mo from surgery, a liver recurrence was described and a chemoembolization was performed. After a further disease progression, based on the correlation between the histological features of the disease and those of the hepatoblastoma, a similar chemotherapy regimen(with cisplatin and ifosfamide/mesna chemotherapy, omitting doxorubicin due to liver impairment) was administered. However, infection of the biliary catheter required a dose modification of the treatment. No benefit was noted and a progression of disease was radiologically assessed after only four cycles. The worsening of the clinical status prevented further treatments, and the patient died a few months later. This case report documents how the NSET might have an aggressive and non-preventable behavior. No chemotherapy schedules with a proved efficacy are available, and new data are needed to shed light on this rare neoplasm.展开更多
Prostate cancer(PCa)ranks as the second most prevalent malignancy among men worldwide.Early diagnosis,personalized treatment,and prognosis prediction of PCa play a crucial role in improving patients’survival rates.Th...Prostate cancer(PCa)ranks as the second most prevalent malignancy among men worldwide.Early diagnosis,personalized treatment,and prognosis prediction of PCa play a crucial role in improving patients’survival rates.The advancement of artificial intelligence(AI),particularly the utilization of deep learning(DL)algorithms,has brought about substantial progress in assisting the diagnosis,treatment,and prognosis prediction of PCa.The introduction of the foundation model has revolutionized the application of AI in medical treatment and facilitated its integration into clinical practice.This review emphasizes the clinical application of AI in PCa by discussing recent advancements from both pathological and imaging perspectives.Furthermore,it explores the current challenges faced by AI in clinical applications while also considering future developments,aiming to provide a valuable point of reference for the integration of AI and clinical applications.展开更多
Syndrome of inappropriate antidiuresis (SIAD) is a common paraneoplastic syndrome commonly associated with thoracic malignancies, gastrointestinal cancers and kidney tumors. It is defined as hyponatremia in euvolemic ...Syndrome of inappropriate antidiuresis (SIAD) is a common paraneoplastic syndrome commonly associated with thoracic malignancies, gastrointestinal cancers and kidney tumors. It is defined as hyponatremia in euvolemic patients, often due to abnormal secretion of antidiuretic hormone by tumor cells. Tolvaptan, a vasopressin-2-receptor antagonist, is currently recommended for patients affected by SIAD with mild or moderate symptoms. Among patients with prostatic cancer, SIAD represents a rare condition but it is frequently associated with poorly differentiated adenocarcinoma or pure small-cell carcinoma histotype. We report a case of SIAD appeared at disease progression in a 60-year-old male patient with acinar adenocarcinoma with neuroendocrine differentiation together with a literature review.展开更多
文摘Nested stromal-epithelial tumor(NSET) is a nonhepatocytic and non-biliary tumor of the liver consisting of nests of epithelial and spindled cells with associated myofibroblastic stroma and variable intra-lesional calcification and ossification, which represents a very rare and challenging disease. Most of the reported cases have been treated with surgery, obtaining a long survival outcome. Here, we report the case of a 31-year-old Caucasian man who underwent surgery at our institution for a large, lobulated, multinodular mass of the right hemi-liver. The histological exam confirmed the diagnosis of NSET. After 6 mo from surgery, a liver recurrence was described and a chemoembolization was performed. After a further disease progression, based on the correlation between the histological features of the disease and those of the hepatoblastoma, a similar chemotherapy regimen(with cisplatin and ifosfamide/mesna chemotherapy, omitting doxorubicin due to liver impairment) was administered. However, infection of the biliary catheter required a dose modification of the treatment. No benefit was noted and a progression of disease was radiologically assessed after only four cycles. The worsening of the clinical status prevented further treatments, and the patient died a few months later. This case report documents how the NSET might have an aggressive and non-preventable behavior. No chemotherapy schedules with a proved efficacy are available, and new data are needed to shed light on this rare neoplasm.
基金This review was supported by the National Natural Science Foundation of China(Nos.82272905 and 82473385)the Natural Science Foundation of Science and Technology Commission of Shanghai(No.22ZR1478000).
文摘Prostate cancer(PCa)ranks as the second most prevalent malignancy among men worldwide.Early diagnosis,personalized treatment,and prognosis prediction of PCa play a crucial role in improving patients’survival rates.The advancement of artificial intelligence(AI),particularly the utilization of deep learning(DL)algorithms,has brought about substantial progress in assisting the diagnosis,treatment,and prognosis prediction of PCa.The introduction of the foundation model has revolutionized the application of AI in medical treatment and facilitated its integration into clinical practice.This review emphasizes the clinical application of AI in PCa by discussing recent advancements from both pathological and imaging perspectives.Furthermore,it explores the current challenges faced by AI in clinical applications while also considering future developments,aiming to provide a valuable point of reference for the integration of AI and clinical applications.
文摘Syndrome of inappropriate antidiuresis (SIAD) is a common paraneoplastic syndrome commonly associated with thoracic malignancies, gastrointestinal cancers and kidney tumors. It is defined as hyponatremia in euvolemic patients, often due to abnormal secretion of antidiuretic hormone by tumor cells. Tolvaptan, a vasopressin-2-receptor antagonist, is currently recommended for patients affected by SIAD with mild or moderate symptoms. Among patients with prostatic cancer, SIAD represents a rare condition but it is frequently associated with poorly differentiated adenocarcinoma or pure small-cell carcinoma histotype. We report a case of SIAD appeared at disease progression in a 60-year-old male patient with acinar adenocarcinoma with neuroendocrine differentiation together with a literature review.
