AIM: To analyze the correlation between preexisting comorbidity and other clinicopathological features, short-term surgical outcome and long-term survival in elderly patients with colorectal cancer (CRC). METHODS: Acc...AIM: To analyze the correlation between preexisting comorbidity and other clinicopathological features, short-term surgical outcome and long-term survival in elderly patients with colorectal cancer (CRC). METHODS: According to age, 403 patients operated on for CRC in our department were divided into group A (< 70 years old) and group B (≥ 70 years old) and analyzed statistically. RESULTS: Rectal localization prevailed in group A (31.6% vs 19.7%, P = 0.027), whereas the percentage of R0 resections was 77% in the two groups. Comorbidity rate was 46.2% and 69.1% for group A and B, respectively (P < 0.001), with a huge difference as regards cardiovascular diseases. Overall, postoperative morbidity was 16.9% and 20.8% in group A and B, respectively (P = 0.367), whereas mortality was limited to group B (4.5%, P = 0.001). In both groups, patients who suffered from postoperative complications had a higher overall comorbidity rate, with preexisting cardiovascular diseases prevailing in group B (P = 0.003). Overall 5-year survival rate was significantly betterfor group A (75.2% vs 55%, P = 0.006), whereas no signif icant difference was observed considering disease-specif ic survival (76.3% vs 76.9%, P = 0.674). CONCLUSION: In spite of an increase in postoperative mortality and a lower overall long-term survival for patients aged ≥ 70 years old, it should be considered that, even in the elderly group, a signif icant number of patients is alive 5 years after CRC resection.展开更多
The ERTMS (European Train Management System) has been developed by the European Union (EU) to enhance safety, increase efficiency and to cross-border interoperability creating a unique solution fulfilling a standardiz...The ERTMS (European Train Management System) has been developed by the European Union (EU) to enhance safety, increase efficiency and to cross-border interoperability creating a unique solution fulfilling a standardized certification process. The ERTMS being able to automatically stop the train to overcome human errors has achieved the highest track record in terms of safety over several billion km travelled each years. GNSS positioning, bearer-independent telecoms and ATO (Automatic Train Operation) are the new features for enhancing the ERTMS in the path to fully autonomous operations. In the same period, the automotive industry has launched ambitious plans for the connected cars and autonomous driving applications are emerging as the next wave of innovation. This paper evaluates the challenges to sharing intelligent infrastructure means, by combining the strengths of the safety benchmark achieved on the rail transport with the mass production capability of the automotive industry to lower the costs. In this scenario, rail and automotive becoming tightly intertwined can get a grip in the race towards a fully automation affordable and safe, giving birth to autonomous vehicles able to travel within virtual rails as “trains” on the road. To this aim we will introduce the two test bed in Italy respectively for validating the ERTMS with GNSS positioning and public telecoms networks and for testing FCA Ducato vans to operate at SAE level 3 automation exploiting the new GALILEO and 5 G services.展开更多
This paper presents a study for finding a solution to the placement of territorial resources for multipurpose wireless services considering also the restrictions imposed by the orography of the territory itself. To so...This paper presents a study for finding a solution to the placement of territorial resources for multipurpose wireless services considering also the restrictions imposed by the orography of the territory itself. To solve this problem genetic algorithms are used to identify sites where to place the resources for the optimal coverage of a given area. The used algorithm has demonstrated to be able to find optimal solutions in a variety of considered situations.展开更多
文摘AIM: To analyze the correlation between preexisting comorbidity and other clinicopathological features, short-term surgical outcome and long-term survival in elderly patients with colorectal cancer (CRC). METHODS: According to age, 403 patients operated on for CRC in our department were divided into group A (< 70 years old) and group B (≥ 70 years old) and analyzed statistically. RESULTS: Rectal localization prevailed in group A (31.6% vs 19.7%, P = 0.027), whereas the percentage of R0 resections was 77% in the two groups. Comorbidity rate was 46.2% and 69.1% for group A and B, respectively (P < 0.001), with a huge difference as regards cardiovascular diseases. Overall, postoperative morbidity was 16.9% and 20.8% in group A and B, respectively (P = 0.367), whereas mortality was limited to group B (4.5%, P = 0.001). In both groups, patients who suffered from postoperative complications had a higher overall comorbidity rate, with preexisting cardiovascular diseases prevailing in group B (P = 0.003). Overall 5-year survival rate was significantly betterfor group A (75.2% vs 55%, P = 0.006), whereas no signif icant difference was observed considering disease-specif ic survival (76.3% vs 76.9%, P = 0.674). CONCLUSION: In spite of an increase in postoperative mortality and a lower overall long-term survival for patients aged ≥ 70 years old, it should be considered that, even in the elderly group, a signif icant number of patients is alive 5 years after CRC resection.
文摘The ERTMS (European Train Management System) has been developed by the European Union (EU) to enhance safety, increase efficiency and to cross-border interoperability creating a unique solution fulfilling a standardized certification process. The ERTMS being able to automatically stop the train to overcome human errors has achieved the highest track record in terms of safety over several billion km travelled each years. GNSS positioning, bearer-independent telecoms and ATO (Automatic Train Operation) are the new features for enhancing the ERTMS in the path to fully autonomous operations. In the same period, the automotive industry has launched ambitious plans for the connected cars and autonomous driving applications are emerging as the next wave of innovation. This paper evaluates the challenges to sharing intelligent infrastructure means, by combining the strengths of the safety benchmark achieved on the rail transport with the mass production capability of the automotive industry to lower the costs. In this scenario, rail and automotive becoming tightly intertwined can get a grip in the race towards a fully automation affordable and safe, giving birth to autonomous vehicles able to travel within virtual rails as “trains” on the road. To this aim we will introduce the two test bed in Italy respectively for validating the ERTMS with GNSS positioning and public telecoms networks and for testing FCA Ducato vans to operate at SAE level 3 automation exploiting the new GALILEO and 5 G services.
文摘This paper presents a study for finding a solution to the placement of territorial resources for multipurpose wireless services considering also the restrictions imposed by the orography of the territory itself. To solve this problem genetic algorithms are used to identify sites where to place the resources for the optimal coverage of a given area. The used algorithm has demonstrated to be able to find optimal solutions in a variety of considered situations.
