Bioorthogonal reactions can take place in biological environments without interfering with biochemical processes.In this study,Pd(PPh_(3))_(2)Cl_(2)was used as a bioorthogonal catalyst to in situ transform the stable ...Bioorthogonal reactions can take place in biological environments without interfering with biochemical processes.In this study,Pd(PPh_(3))_(2)Cl_(2)was used as a bioorthogonal catalyst to in situ transform the stable N-heterocyclic carbene(NHC)-gold(Ⅰ)-alkyne complex 5 to its active species which can effectively inhibit thioredoxin reductase(TrxR)and exhibit significant anticancer bioactivity in hepatocellular carcinoma(HCC).展开更多
This article provides an overview of the application of diruthenium(Ⅱ,Ⅲ)paddlewheel complexes for anticancer purposes.The use of this coordinative construct is indeed attractive because it provides an excellent oppo...This article provides an overview of the application of diruthenium(Ⅱ,Ⅲ)paddlewheel complexes for anticancer purposes.The use of this coordinative construct is indeed attractive because it provides an excellent opportunity to combine the pharmacological properties of the dimetallic ruthenium center with those derived from the specific choice of ligands bearing a carboxylic function capable of coordination towards the Ru-Ru core.展开更多
基金the financial supports of the National Natural Science Foundation of China(Nos.82173684 and 82204181)Nanjing University of Chinese Medicine National Natural Science Foundation of China Counterpart Funding(No.XPT82204181)+5 种基金General Project of Basic Science in Colleges and Universities of Jiangsu Province(No.21KJB350007)Jiangsu Provincial Health Commission(No.Z2021057)the Open Project of Chinese Materia Medica First Class Discipline of Nanjing University of Chinese Medicine(No.2020YLXK010)the Priority Academic Program Development of Jiangsu Higher Education Institutions(Integration of Chinese and Western Medicine)the experimental support from the Experiment Center for Science and Technology,Nanjing University of Chinese Medicinefinancially supported by the“Innovative and Entrepreneurial Team”Program of Jiangsu Province(2020)。
文摘Bioorthogonal reactions can take place in biological environments without interfering with biochemical processes.In this study,Pd(PPh_(3))_(2)Cl_(2)was used as a bioorthogonal catalyst to in situ transform the stable N-heterocyclic carbene(NHC)-gold(Ⅰ)-alkyne complex 5 to its active species which can effectively inhibit thioredoxin reductase(TrxR)and exhibit significant anticancer bioactivity in hepatocellular carcinoma(HCC).
基金support of the Italian Ministry of Research(MUR).
文摘This article provides an overview of the application of diruthenium(Ⅱ,Ⅲ)paddlewheel complexes for anticancer purposes.The use of this coordinative construct is indeed attractive because it provides an excellent opportunity to combine the pharmacological properties of the dimetallic ruthenium center with those derived from the specific choice of ligands bearing a carboxylic function capable of coordination towards the Ru-Ru core.
