AIM To investigate the role of minimally invasive surgery for gastric cancer and determine surgical,clinical,and oncological outcomes.METHODS This is a propensity score-matched case-control study,comparing three treat...AIM To investigate the role of minimally invasive surgery for gastric cancer and determine surgical,clinical,and oncological outcomes.METHODS This is a propensity score-matched case-control study,comparing three treatment arms:robotic gastrectomy(RG),laparoscopic gastrectomy(LG),open gastrectomy(OG).Data collection started after sharing a specific study protocol.Data were recorded through a tailored and protected web-based system.Primary outcomes:harvested lymph nodes,estimated blood loss,hospital stay,complications rate.Among the secondary outcomes,there are:operative time,R0 resections,POD of mobilization,POD of starting liquid diet and soft solid diet.The analysis includes the evaluation of type and grade of postoperative complications.Detailed information of anastomotic leakages is also provided.RESULTS The present analysis was carried out of 1026 gastrectomies.To guarantee homogenous distribution of cases,patients in the RG,LG and OG groups were 1:1:2 matched using a propensity score analysis with a caliper=0.2.The successful matching resulted in a total sample of 604 patients(RG=151;LG=151;OG=302).The three groups showed no differences in all baseline patients characteristics,type of surgery(P=0.42)and stage of the disease(P=0.16).Intraoperative blood loss was significantly lower in the LG(95.93±119.22)and RG(117.91±68.11)groups compared to the OG(127.26±79.50,P=0.002).The mean number of retrieved lymph nodes was similar between the RG(27.78±11.45),LG(24.58±13.56)and OG(25.82±12.07)approach.A benefit in favor of the minimally invasive approaches was found in the length of hospital stay(P<0.0001).A similar complications rate was found(P=0.13).The leakage rate was not different(P=0.78)between groups.CONCLUSION Laparoscopic and robotic surgery can be safely performed and proposed as possible alternative to open surgery.The main highlighted benefit is a faster postoperative functional recovery.展开更多
BACKGROUND Perivascular epithelioid cell tumor(PEComa) is a rare mesenchymal neoplasm that can arise in many different organs with a broad spectrum of biological behavior, from indolent to aggressive progression. Only...BACKGROUND Perivascular epithelioid cell tumor(PEComa) is a rare mesenchymal neoplasm that can arise in many different organs with a broad spectrum of biological behavior, from indolent to aggressive progression. Only ten cases of gastric PEComas have been reported in the English literature, which were treated with endoscopic, laparoscopic, or open resections. Due to its rarity, the optimal surgical management and prognosis of this tumor are still uncertain.CASE SUMMARY We present a case of robotic wedge resection of a 6.5 cm bleeding lesion of the gastric fundus located 3 cm below the esophago-gastric junction in a 55-year-old man. Biopsy revealed a malignant tumor with epithelioid cells focally positive for muscle markers desmin and smooth muscle actin. In addition, histology revealed that the tumor was positive for HMB-45, melan-A(MART-1), microphthalmia transcription factor and negative for pan-cytokeratin AE1/AE3, CD34, p40, DOG-1, CD117(c-kit), S100, CD3, CD79 a, caldesmon and myogenin. These markers suggested the possibility of a PEComa. The patient underwent a diagnostic laparoscopy via the da Vinci? Si? system and robotic wedge resection. Final pathology confirmed a malignant gastric PEComa with negative margins. At his 11-mo follow-up visit, the patient remained disease-free.CONCLUSION Gastric PEComa can be treated with a robotic R0 resection with acceptable postoperative and short-term oncological outcomes.展开更多
基金Supported by CARIT Foundation(Fondazione Cassa di Risparmio di Terni e Narni),No.0024137
文摘AIM To investigate the role of minimally invasive surgery for gastric cancer and determine surgical,clinical,and oncological outcomes.METHODS This is a propensity score-matched case-control study,comparing three treatment arms:robotic gastrectomy(RG),laparoscopic gastrectomy(LG),open gastrectomy(OG).Data collection started after sharing a specific study protocol.Data were recorded through a tailored and protected web-based system.Primary outcomes:harvested lymph nodes,estimated blood loss,hospital stay,complications rate.Among the secondary outcomes,there are:operative time,R0 resections,POD of mobilization,POD of starting liquid diet and soft solid diet.The analysis includes the evaluation of type and grade of postoperative complications.Detailed information of anastomotic leakages is also provided.RESULTS The present analysis was carried out of 1026 gastrectomies.To guarantee homogenous distribution of cases,patients in the RG,LG and OG groups were 1:1:2 matched using a propensity score analysis with a caliper=0.2.The successful matching resulted in a total sample of 604 patients(RG=151;LG=151;OG=302).The three groups showed no differences in all baseline patients characteristics,type of surgery(P=0.42)and stage of the disease(P=0.16).Intraoperative blood loss was significantly lower in the LG(95.93±119.22)and RG(117.91±68.11)groups compared to the OG(127.26±79.50,P=0.002).The mean number of retrieved lymph nodes was similar between the RG(27.78±11.45),LG(24.58±13.56)and OG(25.82±12.07)approach.A benefit in favor of the minimally invasive approaches was found in the length of hospital stay(P<0.0001).A similar complications rate was found(P=0.13).The leakage rate was not different(P=0.78)between groups.CONCLUSION Laparoscopic and robotic surgery can be safely performed and proposed as possible alternative to open surgery.The main highlighted benefit is a faster postoperative functional recovery.
文摘BACKGROUND Perivascular epithelioid cell tumor(PEComa) is a rare mesenchymal neoplasm that can arise in many different organs with a broad spectrum of biological behavior, from indolent to aggressive progression. Only ten cases of gastric PEComas have been reported in the English literature, which were treated with endoscopic, laparoscopic, or open resections. Due to its rarity, the optimal surgical management and prognosis of this tumor are still uncertain.CASE SUMMARY We present a case of robotic wedge resection of a 6.5 cm bleeding lesion of the gastric fundus located 3 cm below the esophago-gastric junction in a 55-year-old man. Biopsy revealed a malignant tumor with epithelioid cells focally positive for muscle markers desmin and smooth muscle actin. In addition, histology revealed that the tumor was positive for HMB-45, melan-A(MART-1), microphthalmia transcription factor and negative for pan-cytokeratin AE1/AE3, CD34, p40, DOG-1, CD117(c-kit), S100, CD3, CD79 a, caldesmon and myogenin. These markers suggested the possibility of a PEComa. The patient underwent a diagnostic laparoscopy via the da Vinci? Si? system and robotic wedge resection. Final pathology confirmed a malignant gastric PEComa with negative margins. At his 11-mo follow-up visit, the patient remained disease-free.CONCLUSION Gastric PEComa can be treated with a robotic R0 resection with acceptable postoperative and short-term oncological outcomes.
