We report a case of metastatic castration-resistant prostate cancer, who received prior treatment with docetaxel and was then given cabazitaxel as salvage therapy. The patient was monitored by prostate-specific antige...We report a case of metastatic castration-resistant prostate cancer, who received prior treatment with docetaxel and was then given cabazitaxel as salvage therapy. The patient was monitored by prostate-specific antigen doubling time and prostate-specific antigen absolute value. The prostate-specific antigen doubling time was found to be a good response predictor in the patient.展开更多
Understanding the neural substrates of human cognition is a central goal of neuroscience research.Modern imaging techniques,such as functional magnetic resonance imaging(fMRI),provide an opportunity to map cognitive f...Understanding the neural substrates of human cognition is a central goal of neuroscience research.Modern imaging techniques,such as functional magnetic resonance imaging(fMRI),provide an opportunity to map cognitive function in vivo.To date,modeling shared information in task-evoked neural dynamics across individuals remains challenging,largely due to pronounced inter-subject variability in brain anatomy,function,and behaviors[1],[2].An emerging topic,known as hyperalignment or functional alignment,has been proposed recently[3],to map subject-specific neural responses onto a common representational space using either linear transformations of task-evoked neural activity[4]or resting-state connectivity profiles[5].However,these approaches often assume uniform neural responses across individuals,struggling to capture group heterogeneity and model functional interactions between brain areas[6].展开更多
文摘We report a case of metastatic castration-resistant prostate cancer, who received prior treatment with docetaxel and was then given cabazitaxel as salvage therapy. The patient was monitored by prostate-specific antigen doubling time and prostate-specific antigen absolute value. The prostate-specific antigen doubling time was found to be a good response predictor in the patient.
基金supported by the STI2030-Major Projects(2021ZD0200201,2022ZD0211500)the National Natural Science Foundation of China(62201519,52307259,62327805,and 82151307).
文摘Understanding the neural substrates of human cognition is a central goal of neuroscience research.Modern imaging techniques,such as functional magnetic resonance imaging(fMRI),provide an opportunity to map cognitive function in vivo.To date,modeling shared information in task-evoked neural dynamics across individuals remains challenging,largely due to pronounced inter-subject variability in brain anatomy,function,and behaviors[1],[2].An emerging topic,known as hyperalignment or functional alignment,has been proposed recently[3],to map subject-specific neural responses onto a common representational space using either linear transformations of task-evoked neural activity[4]or resting-state connectivity profiles[5].However,these approaches often assume uniform neural responses across individuals,struggling to capture group heterogeneity and model functional interactions between brain areas[6].
