Ebola virus disease is one of the most deadly ailments known to mankind due to its high mortality rate(up to 90%) accompanying with the disease. Ebola haemorrhagic fever(EHF) is an infectious disease of animal that ca...Ebola virus disease is one of the most deadly ailments known to mankind due to its high mortality rate(up to 90%) accompanying with the disease. Ebola haemorrhagic fever(EHF) is an infectious disease of animal that can be transmitted to both human and non-human primates. The first epidemic of EHF occurred in 1976 in the Democratic Republic of the Congo. The incubation period of ebola is less than 21 days. Ebola virus infections are depicted by immune suppression and a systemic inflammatory response that leads to damage of the vascular, coagulation and immune systems, causing multi-organ failure and shock. Five genetically distinct members of the Filoviridae family responsible for EHF are as follows: Zaire ebolavirus, Sudan ebolavirus, C?te d'Ivoire ebolavirus, Bundibugyo ebolavirus and Reston ebolavirus. The ongoing 2014 West Africa ebola epidemic has been considered as the most serious panic in the medical field with respect to both the number of human cases and death toll. The natural host for ebola virus is unknown, thus it is not possible to carry out programs to regulate or abolish virus from transmission to people. The ebola virus infection provides little chance to develop acquired immunity causing rapid progression of the disease. It is pertinent to mention that at present, there is no antiviral therapy or vaccine that is helpful against ebola virus infection in humans. The impediment of EHF necessitates much better understanding of the epidemiology of the disease, particularly the role of wildlife, as well as bats, in the spread of ebola virus to humans.展开更多
BACKGROUND The T-cell costimulation blocking agent belatacept has been identified as a possible substitute for calcineurin inhibitors,however,no consensus has been established against its use over the standard care ag...BACKGROUND The T-cell costimulation blocking agent belatacept has been identified as a possible substitute for calcineurin inhibitors,however,no consensus has been established against its use over the standard care agent Tacrolimus.AIM To evaluate the effectiveness of belatacept based maintenance immunosuppressive regimens in comparison to tacrolimus in renal transplantion.METHODS We did extensive search of all the available literature comparing the role of belatacept to tacrolimus in renal transplant recipients by searching the PubMed,Embase,Cochrane,Crossref,Scopus,clinical trials registry on October 5,2020.RESULTS The literature search identified four randomized controlled trials(n=173 participants)comparing belatacept with tacrolimus.There was no significant difference in estimated renal function at 12 mo[mean difference 4.12 mL/min/1.73 m^(2),confidence interval(CI):-2.18 to 10.42,P=0.20].Further,belatacept group was associated with significant increase in biopsy proven acute rejection[relative risk(RR)=3.27,CI:0.88 to 12.11,P=0.08]and worse 12 mo allograft survival(RR=4.51,CI:1.23 to 16.58,P=0.02).However,incidence of new onset diabetes mellitus was lower with belatacept at 12 mo(RR=0.26,CI:0.07 to 0.99,P=0.05).CONCLUSION The evidence reviewed in this meta-analysis suggested that belatacept-based maintenance immunosuppression regimens were associated with an increased risk allograft loss in renal transplant recipients with equivalent renal functioning against standard tacrolimus;however,observed significantly reduced new onset diabetes mellitus after transplantation incidence and lower serum low density lipid profile levels in belatacept group.In addition,the adaptation of belatacept in renal transplantation has been forestalled by increased rates of rejection and resistance owing to development of various effector memory T cells through,parallel differentiation and immunological plasticity.展开更多
The complex perovskite oxide a strontium gadolinium niobate (SGN) synthesized by solid-state reaction technique has single phase with tetragonal structure. X-ray diffraction (XRD) technique and scanning electron micro...The complex perovskite oxide a strontium gadolinium niobate (SGN) synthesized by solid-state reaction technique has single phase with tetragonal structure. X-ray diffraction (XRD) technique and scanning electron microscopy (SEM) were used to study the structural and microstructural properties of the ceramics, respectively. The XRD patterns of SGN at room temperature show a tetragonal structure. Studies of the dielectric constant and dielectric loss of compound as a function of frequency (50 Hz to 1 MHz) at room temperature, and as a function of temperature (60°C to 420°C) indicate polydispersive nature of the material. The logarithmic angular frequency dependence of the loss peak is found to obey the Arrhenius law with activation energy ~0.18 eV. The small value of activation energy of the compound (~0.18 eV) can be explained by mixed ionic-polaronic conductivity mechanism. The grain size of the pellet sample was found to be 1.92 μm. The frequency-dependant electrical data are analyzed in the framework of conductivity and electric modulus formalisms. The complex plane impedance plot shows the grain boundary contribution for higher value of dielectric constant in the law frequency region.展开更多
A complex structure of barium iron niobate, Ba(Fe0.5Nb0.5)O3 (BFN) and strontium titanate SrTiO3 (ST) was fabricated by a solid-state reaction method. The phase formation of Ba(Fe0.5Nb0.5)O3-SrTiO3 was checked using X...A complex structure of barium iron niobate, Ba(Fe0.5Nb0.5)O3 (BFN) and strontium titanate SrTiO3 (ST) was fabricated by a solid-state reaction method. The phase formation of Ba(Fe0.5Nb0.5)O3-SrTiO3 was checked using X-ray diffraction (XRD) technique. The X-ray structural analysis of BFN and BFN-ST ceramics, showed the formation of single-phase compound in the monoclinic system, which is a distorted structure of an ideal cubic perovskite. Careful examination of microstructures of the individual compounds of the system was done by the scanning electron micrograph (SEM), and confirms the polycrystalline nature of the systems. Detailed studies of dielectric and electrical impedance properties of the systems in a wide range of frequency (100Hz - 5MHz) and different temperatures (30°C-285°C) showed that these properties are strongly dependent on temperature and frequency.展开更多
The imbalance between incoming and outgoing salt causes salinization of soils and sub-soils that result in increasing the salinity of stream-flows and agriculture land.This salinization is a serious environmental haza...The imbalance between incoming and outgoing salt causes salinization of soils and sub-soils that result in increasing the salinity of stream-flows and agriculture land.This salinization is a serious environmental hazard particularly in semi-arid and arid lands.In order to estimate the magnitude of the hazard posed by salinity,it is important to understand and identify the processes that control salt movement from the soil surface through the root zone to the ground water and stream flows.In the present study,Yamuna sub-basin(both sides of Gokul dam site)has been selected which has two distinct climatic zones,sub-humid(upstream of Mathura)and semi-arid region(downstream of Mathura).In the upstream,both surface and ground waters are used for irrigation,whereas in the downstream mostly groundwater is used.Both soils and ground waters are more saline in downstream parts of the study area.In this study we characterized the soil salinity and groundwater quality in both areas.An attempt is also made to model the distribution of potassium concentration in the soil profile in response to varying irrigation conditions using the Soil-Water Infiltration and Movement(SWIM)model.Fair agreement was obtained between predicted and measured results indicating the applicability of the model.展开更多
基金Supported by Department of Science and Technology-Science and Engineering Research Board(DST-SERB),New Delhi,India
文摘Ebola virus disease is one of the most deadly ailments known to mankind due to its high mortality rate(up to 90%) accompanying with the disease. Ebola haemorrhagic fever(EHF) is an infectious disease of animal that can be transmitted to both human and non-human primates. The first epidemic of EHF occurred in 1976 in the Democratic Republic of the Congo. The incubation period of ebola is less than 21 days. Ebola virus infections are depicted by immune suppression and a systemic inflammatory response that leads to damage of the vascular, coagulation and immune systems, causing multi-organ failure and shock. Five genetically distinct members of the Filoviridae family responsible for EHF are as follows: Zaire ebolavirus, Sudan ebolavirus, C?te d'Ivoire ebolavirus, Bundibugyo ebolavirus and Reston ebolavirus. The ongoing 2014 West Africa ebola epidemic has been considered as the most serious panic in the medical field with respect to both the number of human cases and death toll. The natural host for ebola virus is unknown, thus it is not possible to carry out programs to regulate or abolish virus from transmission to people. The ebola virus infection provides little chance to develop acquired immunity causing rapid progression of the disease. It is pertinent to mention that at present, there is no antiviral therapy or vaccine that is helpful against ebola virus infection in humans. The impediment of EHF necessitates much better understanding of the epidemiology of the disease, particularly the role of wildlife, as well as bats, in the spread of ebola virus to humans.
文摘BACKGROUND The T-cell costimulation blocking agent belatacept has been identified as a possible substitute for calcineurin inhibitors,however,no consensus has been established against its use over the standard care agent Tacrolimus.AIM To evaluate the effectiveness of belatacept based maintenance immunosuppressive regimens in comparison to tacrolimus in renal transplantion.METHODS We did extensive search of all the available literature comparing the role of belatacept to tacrolimus in renal transplant recipients by searching the PubMed,Embase,Cochrane,Crossref,Scopus,clinical trials registry on October 5,2020.RESULTS The literature search identified four randomized controlled trials(n=173 participants)comparing belatacept with tacrolimus.There was no significant difference in estimated renal function at 12 mo[mean difference 4.12 mL/min/1.73 m^(2),confidence interval(CI):-2.18 to 10.42,P=0.20].Further,belatacept group was associated with significant increase in biopsy proven acute rejection[relative risk(RR)=3.27,CI:0.88 to 12.11,P=0.08]and worse 12 mo allograft survival(RR=4.51,CI:1.23 to 16.58,P=0.02).However,incidence of new onset diabetes mellitus was lower with belatacept at 12 mo(RR=0.26,CI:0.07 to 0.99,P=0.05).CONCLUSION The evidence reviewed in this meta-analysis suggested that belatacept-based maintenance immunosuppression regimens were associated with an increased risk allograft loss in renal transplant recipients with equivalent renal functioning against standard tacrolimus;however,observed significantly reduced new onset diabetes mellitus after transplantation incidence and lower serum low density lipid profile levels in belatacept group.In addition,the adaptation of belatacept in renal transplantation has been forestalled by increased rates of rejection and resistance owing to development of various effector memory T cells through,parallel differentiation and immunological plasticity.
文摘The complex perovskite oxide a strontium gadolinium niobate (SGN) synthesized by solid-state reaction technique has single phase with tetragonal structure. X-ray diffraction (XRD) technique and scanning electron microscopy (SEM) were used to study the structural and microstructural properties of the ceramics, respectively. The XRD patterns of SGN at room temperature show a tetragonal structure. Studies of the dielectric constant and dielectric loss of compound as a function of frequency (50 Hz to 1 MHz) at room temperature, and as a function of temperature (60°C to 420°C) indicate polydispersive nature of the material. The logarithmic angular frequency dependence of the loss peak is found to obey the Arrhenius law with activation energy ~0.18 eV. The small value of activation energy of the compound (~0.18 eV) can be explained by mixed ionic-polaronic conductivity mechanism. The grain size of the pellet sample was found to be 1.92 μm. The frequency-dependant electrical data are analyzed in the framework of conductivity and electric modulus formalisms. The complex plane impedance plot shows the grain boundary contribution for higher value of dielectric constant in the law frequency region.
文摘A complex structure of barium iron niobate, Ba(Fe0.5Nb0.5)O3 (BFN) and strontium titanate SrTiO3 (ST) was fabricated by a solid-state reaction method. The phase formation of Ba(Fe0.5Nb0.5)O3-SrTiO3 was checked using X-ray diffraction (XRD) technique. The X-ray structural analysis of BFN and BFN-ST ceramics, showed the formation of single-phase compound in the monoclinic system, which is a distorted structure of an ideal cubic perovskite. Careful examination of microstructures of the individual compounds of the system was done by the scanning electron micrograph (SEM), and confirms the polycrystalline nature of the systems. Detailed studies of dielectric and electrical impedance properties of the systems in a wide range of frequency (100Hz - 5MHz) and different temperatures (30°C-285°C) showed that these properties are strongly dependent on temperature and frequency.
文摘The imbalance between incoming and outgoing salt causes salinization of soils and sub-soils that result in increasing the salinity of stream-flows and agriculture land.This salinization is a serious environmental hazard particularly in semi-arid and arid lands.In order to estimate the magnitude of the hazard posed by salinity,it is important to understand and identify the processes that control salt movement from the soil surface through the root zone to the ground water and stream flows.In the present study,Yamuna sub-basin(both sides of Gokul dam site)has been selected which has two distinct climatic zones,sub-humid(upstream of Mathura)and semi-arid region(downstream of Mathura).In the upstream,both surface and ground waters are used for irrigation,whereas in the downstream mostly groundwater is used.Both soils and ground waters are more saline in downstream parts of the study area.In this study we characterized the soil salinity and groundwater quality in both areas.An attempt is also made to model the distribution of potassium concentration in the soil profile in response to varying irrigation conditions using the Soil-Water Infiltration and Movement(SWIM)model.Fair agreement was obtained between predicted and measured results indicating the applicability of the model.
