With the advances in allogeneic hematopoietic cell transplantation(allo-HCT)and supportive care,the number of allo-HCT for elderly patients has been increasing in recent years.However,the advanced donor age limits the...With the advances in allogeneic hematopoietic cell transplantation(allo-HCT)and supportive care,the number of allo-HCT for elderly patients has been increasing in recent years.However,the advanced donor age limits the availability of human leukocyte antigen(HLA)-matched sibling donors(MSD)for elderly individuals.展开更多
Infections are frequent complications in patients with hematological disorders,and pathogen diagnosis remains challenging.Metagenomic next-generation sequencing(mNGS)is an unbiased high-throughput technology that has ...Infections are frequent complications in patients with hematological disorders,and pathogen diagnosis remains challenging.Metagenomic next-generation sequencing(mNGS)is an unbiased high-throughput technology that has been widely applied in the diagnosis of infectious diseases.However,to date,there are no established international guidelines or expert consensuses regarding the use of mNGS to diagnose infections in patients with hematologic disorders.The Anti-Infection Study Group of the Chinese Society of Hematology invited experts in the fields of hematology,microbiology,and mNGS technology to draft an expert consensus focused on clinical indications,sample collection,quality control,and interpretation of results.This consensus will likely contribute to clarifying the medical indications for mNGS testing,optimizing the interpretation of reports,and becoming an inspiration for global practice.展开更多
基金supported by National Natural Science Foundation of China(No.82370215,82020108003,and 82330008)Priority Academic Program Development of Jiangsu Higher Education Institutions(PAPD),Jiangsu Provincial Medical Innovation Center(No.CXZX202201)Science and Technology Program of Suzhou(No.SKY2023047)。
文摘With the advances in allogeneic hematopoietic cell transplantation(allo-HCT)and supportive care,the number of allo-HCT for elderly patients has been increasing in recent years.However,the advanced donor age limits the availability of human leukocyte antigen(HLA)-matched sibling donors(MSD)for elderly individuals.
基金supported by the Chinese Academy of Medical Sciences Innovation Fund for Medical Sciences(grants 2021-I2M-1-017,2023-I2M-2-007)the National Natural Sciences Foundation of China(82470208)the National Key R&D Program of China(2024YFC2510500).
文摘Infections are frequent complications in patients with hematological disorders,and pathogen diagnosis remains challenging.Metagenomic next-generation sequencing(mNGS)is an unbiased high-throughput technology that has been widely applied in the diagnosis of infectious diseases.However,to date,there are no established international guidelines or expert consensuses regarding the use of mNGS to diagnose infections in patients with hematologic disorders.The Anti-Infection Study Group of the Chinese Society of Hematology invited experts in the fields of hematology,microbiology,and mNGS technology to draft an expert consensus focused on clinical indications,sample collection,quality control,and interpretation of results.This consensus will likely contribute to clarifying the medical indications for mNGS testing,optimizing the interpretation of reports,and becoming an inspiration for global practice.
