Background:We aimed to explore the value of echocardiography plus cardiopulmonary exercise testing(CPET)for predicting the functional status and adverse outcomes of adult patients with congenital heart disease(CHD),an...Background:We aimed to explore the value of echocardiography plus cardiopulmonary exercise testing(CPET)for predicting the functional status and adverse outcomes of adult patients with congenital heart disease(CHD),and to develop a multivariate prediction model.Methods:Subjects(135 in total)in this single-center prospective cohort study were enrolled from adult patients suffering from CHD treated in this hospital during January 2021 and August 2023.Standardized echocardiography and CPET were conducted on all subjects at enrollment,with such indicators as left ventricular ejection fraction(LVEF),right ventricular function parameters,peak oxygen uptake(peak VO_(2)),and carbon dioxide ventilatory equivalent slope[ventilation(VE)/carbon dioxide output(VCO_(2))slope]recorded.Results:In contrast with the non-event group,the event group exhibited higher levels of N-terminal pro-B-type natriuretic peptide(NT-proBNP)and lower LVEF and peak VO_(2)(p<0.05).Four key predictors(age,NT-proBNP,LVEF and peak VO_(2))were acquired after Least Absolute Shrinkage and Selection Operator(LASSO)regression analysis.According to Cox analysis,age and NT-proBNP served as risk factors,while LVEF and peak VO_(2)acted as protective factors(p<0.05).As to the Logistic model,its area under curve(AUC)was 0.920,the mean AUC in cross-validation was 0.919,and the SHAPLEY Additive exPlanations(SHAP)analysis results were in line with the Cox model.Conclusions:Echocardiography plus CPET is capable of effectively forecasting the functional status and adverse outcomes of adult CHD patients,and the key independent predictors are age,NT-proBNP,LVEF and peak VO_(2).展开更多
High-nickel cathode LiNi_(0.8)Co_(0.1)Mn_(0.1)O_(2)(NCM811)could enable lithium-ion batteries(LIBs)with high energy density.However,excessive decomposition of the electrolyte would happen in the high operating voltage...High-nickel cathode LiNi_(0.8)Co_(0.1)Mn_(0.1)O_(2)(NCM811)could enable lithium-ion batteries(LIBs)with high energy density.However,excessive decomposition of the electrolyte would happen in the high operating voltage range.In addition,the utilization of flammable organic solvents would increase safety risks in the high temperature environment.Herein,an electrolyte consisting of flame-retardant solvents with lower highest occupied molecular orbital(HOMO)level and LiDFOB salt is proposed to address above two issues.As a result,a thin and robust cathode-electrolyte interface containing rich LiF and Li-B-O compounds is formed on the cathode to effectively suppress electrolyte decomposition in the high operating voltage.The NCM811||Li cell paired with this designed electrolyte possesses a capacity retention of 72%after 300 cycles at 55℃.This work provides insights into developing electrolyte for stable high-nickel cathode operated in the high temperature.展开更多
OBJECTIVE To investigate the significance of angiogenesis of lung cancer,in order to provide a scientific basis for interventional therapy.METHODS Double-phase enhancementscanning spiral CT and DSA were performed in 5...OBJECTIVE To investigate the significance of angiogenesis of lung cancer,in order to provide a scientific basis for interventional therapy.METHODS Double-phase enhancementscanning spiral CT and DSA were performed in 56 pathologically confi rmed lung cancer cases,in order to evaluate angiogenesis of the tumors.The patients included 36 males and 20 females,with ages ranging from 33 to 76 years(average of 53).Assessments and indexes for SCT and DSA examinations were as follows:a)Peak value(PV)of the cancerous focus was the difference between the maximum CT value after enhancement and the CT value of a plain scan;b)The abnormally distorted and expanded new vessels of the cancerous focus which could be macroscopically discriminated;c)DSA staining of the focus of cancer was sparse,grid-like and dense.Chemotherapy and embolotherapy via the bronchial artery(interventional therapy)were conducted.Radiotherapy was added for some of the solid tumors with a diameter exceeding 4 cm.RESULTS a)There were 25 cases with a central-type lesion,among which 4 were small cell lung cancers(SCLC)and 21 non-small cell lung cancers(NSCLC).The cases with a peripheral location accounted for 31 of the total,with a maximum diameter of 1.5 to 13.5 cm and a median of 4.2 cm,including 5 small cell lung cancers and 26 NSCLC cases.b)The reinforced PVs of the cancerous foci were as follows:The PV ranged from 45 to 70 Hu in 34 cases,25 to 45 Hu in 19,and 10 to 25 Hu in 3.Sparse DSA staining occurred in 3 cases,there was uneven grid-like staining in 22 and dense staining in 31;c)The interventional therapy via the bronchial artery was con-ducted twice in 5 cases with the SCLC,and three times in 4 SCLC cases.For 3 of the latter cases,a dose of 5,000 to 7,000 cGy radiation therapy was added during the interventional treatment.Complete remissions(CR)were seen in 88.9%of the cases(8/9)and partial remission(PR)in 11.1%(1/9).Interventional therapy was conducted twice in 8 cases with NSCLC and three times in 30 with NSCLC and four times in 9 cases.Among the total cases,13 received radiotherapy during interventional therapy,with a radiation dose of 5,000-7,000 cGy;The CR rate was 78.7%(37/47),PR was 14.9%(7/47)and the rate of non-remission was 6.4%(3/47).CONCLUSION Using imaging technology,analysis of angiogenesis of lung cancers was employed to accurately detect and quantify angiogenesis.This analysis was combined for interventional therapy,using embolizing agents and large doses of the anti-tumor drugs and angiogenesis inhibitors.The agents were selectively delivered into the tumor vessels to eliminate the primary tumor,in order to depress distant metastases and thus enhance the curative effect of the therapy.展开更多
Dysfunction of the Hippo pathway enables cells to evade contact inhibition and provides advantages for cancerous overgrowth.However,for a significant portion of human cancer,how Hippo signaling is perturbed remains un...Dysfunction of the Hippo pathway enables cells to evade contact inhibition and provides advantages for cancerous overgrowth.However,for a significant portion of human cancer,how Hippo signaling is perturbed remains unknown.To answer this question,we performed a genome-wide screening for genes that affect the Hippo pathway in Drosophila and cross-referenced the hit genes with human cancer genome.In our screen,Prosap was identified as a novel regulator of the Hippo pathway that potently affects tissue growth.Interestingly,a mammalian homolog of Prosap,SHANK2,is the most frequently amplified gene on 11 q13,a major tumor amplicon in human cancer.Gene amplification profile in this 11q13 amplicon clearly indicates selective pressure for SHANK2 amplification.More importantly,across the human cancer genome,SHANK2 is the most frequently amplified gene that is not located within the Myc amplicon.Further studies in multiple human cell lines confirmed that SHANK2 overexpression causes deregulation of Hippo signaling through competitive binding for a LATS1 activator,and as a potential oncogene,SHANK2 promotes cellular transformation and tumor formation in vivo.In cancer cell lines with deregulated Hippo pathway,depletion of SHANK2 restores Hippo signaling and ceases cellular proliferation.Taken together,these results suggest that SHANK2 is an evolutionarily conserved Hippo pathway regulator,commonly amplified in human cancer and potently promotes cancer.Our study for the first time illustrated oncogenic function of SHANK2,one of the most frequently amplified gene in human cancer.Furthermore,given that in normal adult tissues,SHANK2 s expression is largely restricted to the nervous system,SHANK2 may represent an interesting target for anticancer therapy.展开更多
This study aimed to investigate the status of and changes in the vaccination willingness of patients with breast cancer to increase the coronavirus disease 2019(COVID-19)vaccination rate among these patients.The first...This study aimed to investigate the status of and changes in the vaccination willingness of patients with breast cancer to increase the coronavirus disease 2019(COVID-19)vaccination rate among these patients.The first survey included patients fromthe FifthMedical Center of the PLA GeneralHospitalwho participated in the Society of ClinicalOncology Breast Cancer CommitteeNCP-02 study conducted from September 16 to December 31,2021.The second survey was conducted from December 9 to December 26,2022,for those who had not received vaccines previously.In total,266 patients completed two questionnaires.A total of 143 patients(53.8%)changed their willingness to receive the vaccination.Among them,45,who were initially unwilling to be vaccinated,changed their stance to become hesitant and 15 changed to become willing.Among those with hesitant attitudes toward vaccines,45 changed their stance to become willing,and 28 changed to become unwilling;10 patients with willing attitudes toward vaccines changed to become hesitant.Those who received surgery(odds ratio(OR),4.24;95%confidence interval(CI),1.45–12.42;P=0.01)andwho lived with older adults or children(OR,2.03;95%CI,1.13–3.62;P=0.02)were more likely to change their attitudes toward COVID-19 vaccines.This finding suggested that patients with breast cancer were cautious about receiving the COVID-19 vaccine.Multiple methods should be used to promote vaccination and reduce vaccine hesitancy.展开更多
文摘Background:We aimed to explore the value of echocardiography plus cardiopulmonary exercise testing(CPET)for predicting the functional status and adverse outcomes of adult patients with congenital heart disease(CHD),and to develop a multivariate prediction model.Methods:Subjects(135 in total)in this single-center prospective cohort study were enrolled from adult patients suffering from CHD treated in this hospital during January 2021 and August 2023.Standardized echocardiography and CPET were conducted on all subjects at enrollment,with such indicators as left ventricular ejection fraction(LVEF),right ventricular function parameters,peak oxygen uptake(peak VO_(2)),and carbon dioxide ventilatory equivalent slope[ventilation(VE)/carbon dioxide output(VCO_(2))slope]recorded.Results:In contrast with the non-event group,the event group exhibited higher levels of N-terminal pro-B-type natriuretic peptide(NT-proBNP)and lower LVEF and peak VO_(2)(p<0.05).Four key predictors(age,NT-proBNP,LVEF and peak VO_(2))were acquired after Least Absolute Shrinkage and Selection Operator(LASSO)regression analysis.According to Cox analysis,age and NT-proBNP served as risk factors,while LVEF and peak VO_(2)acted as protective factors(p<0.05).As to the Logistic model,its area under curve(AUC)was 0.920,the mean AUC in cross-validation was 0.919,and the SHAPLEY Additive exPlanations(SHAP)analysis results were in line with the Cox model.Conclusions:Echocardiography plus CPET is capable of effectively forecasting the functional status and adverse outcomes of adult CHD patients,and the key independent predictors are age,NT-proBNP,LVEF and peak VO_(2).
基金supported by the National Key Research and Development Program of China(2022YFB3803400)。
文摘High-nickel cathode LiNi_(0.8)Co_(0.1)Mn_(0.1)O_(2)(NCM811)could enable lithium-ion batteries(LIBs)with high energy density.However,excessive decomposition of the electrolyte would happen in the high operating voltage range.In addition,the utilization of flammable organic solvents would increase safety risks in the high temperature environment.Herein,an electrolyte consisting of flame-retardant solvents with lower highest occupied molecular orbital(HOMO)level and LiDFOB salt is proposed to address above two issues.As a result,a thin and robust cathode-electrolyte interface containing rich LiF and Li-B-O compounds is formed on the cathode to effectively suppress electrolyte decomposition in the high operating voltage.The NCM811||Li cell paired with this designed electrolyte possesses a capacity retention of 72%after 300 cycles at 55℃.This work provides insights into developing electrolyte for stable high-nickel cathode operated in the high temperature.
文摘OBJECTIVE To investigate the significance of angiogenesis of lung cancer,in order to provide a scientific basis for interventional therapy.METHODS Double-phase enhancementscanning spiral CT and DSA were performed in 56 pathologically confi rmed lung cancer cases,in order to evaluate angiogenesis of the tumors.The patients included 36 males and 20 females,with ages ranging from 33 to 76 years(average of 53).Assessments and indexes for SCT and DSA examinations were as follows:a)Peak value(PV)of the cancerous focus was the difference between the maximum CT value after enhancement and the CT value of a plain scan;b)The abnormally distorted and expanded new vessels of the cancerous focus which could be macroscopically discriminated;c)DSA staining of the focus of cancer was sparse,grid-like and dense.Chemotherapy and embolotherapy via the bronchial artery(interventional therapy)were conducted.Radiotherapy was added for some of the solid tumors with a diameter exceeding 4 cm.RESULTS a)There were 25 cases with a central-type lesion,among which 4 were small cell lung cancers(SCLC)and 21 non-small cell lung cancers(NSCLC).The cases with a peripheral location accounted for 31 of the total,with a maximum diameter of 1.5 to 13.5 cm and a median of 4.2 cm,including 5 small cell lung cancers and 26 NSCLC cases.b)The reinforced PVs of the cancerous foci were as follows:The PV ranged from 45 to 70 Hu in 34 cases,25 to 45 Hu in 19,and 10 to 25 Hu in 3.Sparse DSA staining occurred in 3 cases,there was uneven grid-like staining in 22 and dense staining in 31;c)The interventional therapy via the bronchial artery was con-ducted twice in 5 cases with the SCLC,and three times in 4 SCLC cases.For 3 of the latter cases,a dose of 5,000 to 7,000 cGy radiation therapy was added during the interventional treatment.Complete remissions(CR)were seen in 88.9%of the cases(8/9)and partial remission(PR)in 11.1%(1/9).Interventional therapy was conducted twice in 8 cases with NSCLC and three times in 30 with NSCLC and four times in 9 cases.Among the total cases,13 received radiotherapy during interventional therapy,with a radiation dose of 5,000-7,000 cGy;The CR rate was 78.7%(37/47),PR was 14.9%(7/47)and the rate of non-remission was 6.4%(3/47).CONCLUSION Using imaging technology,analysis of angiogenesis of lung cancers was employed to accurately detect and quantify angiogenesis.This analysis was combined for interventional therapy,using embolizing agents and large doses of the anti-tumor drugs and angiogenesis inhibitors.The agents were selectively delivered into the tumor vessels to eliminate the primary tumor,in order to depress distant metastases and thus enhance the curative effect of the therapy.
基金This work was supported by the National Natural Science Foundation of China （Grant Nos. 41172110 and 61107090） and Shandong Provincial Natural Science Foundation （Grant No. ZR2011BZ007）.
基金This work was supported by the major scientific research project(Grant Nos.2017YFA0504503,2019YFA0802001 and 2017YFA0103601)the National Natural Science Foundation of China(Grant Nos.81972600,31530043 and 31625017)the Strategic Priority Research Program of Chinese Academy of Sciences,Grant No.XDB19000000.
文摘Dysfunction of the Hippo pathway enables cells to evade contact inhibition and provides advantages for cancerous overgrowth.However,for a significant portion of human cancer,how Hippo signaling is perturbed remains unknown.To answer this question,we performed a genome-wide screening for genes that affect the Hippo pathway in Drosophila and cross-referenced the hit genes with human cancer genome.In our screen,Prosap was identified as a novel regulator of the Hippo pathway that potently affects tissue growth.Interestingly,a mammalian homolog of Prosap,SHANK2,is the most frequently amplified gene on 11 q13,a major tumor amplicon in human cancer.Gene amplification profile in this 11q13 amplicon clearly indicates selective pressure for SHANK2 amplification.More importantly,across the human cancer genome,SHANK2 is the most frequently amplified gene that is not located within the Myc amplicon.Further studies in multiple human cell lines confirmed that SHANK2 overexpression causes deregulation of Hippo signaling through competitive binding for a LATS1 activator,and as a potential oncogene,SHANK2 promotes cellular transformation and tumor formation in vivo.In cancer cell lines with deregulated Hippo pathway,depletion of SHANK2 restores Hippo signaling and ceases cellular proliferation.Taken together,these results suggest that SHANK2 is an evolutionarily conserved Hippo pathway regulator,commonly amplified in human cancer and potently promotes cancer.Our study for the first time illustrated oncogenic function of SHANK2,one of the most frequently amplified gene in human cancer.Furthermore,given that in normal adult tissues,SHANK2 s expression is largely restricted to the nervous system,SHANK2 may represent an interesting target for anticancer therapy.
基金supported by the Emergency Key Program of Guangzhou Laboratory(EKPG21-30-4)Beijing Science and Technology Plan(Z181100001718215).
文摘This study aimed to investigate the status of and changes in the vaccination willingness of patients with breast cancer to increase the coronavirus disease 2019(COVID-19)vaccination rate among these patients.The first survey included patients fromthe FifthMedical Center of the PLA GeneralHospitalwho participated in the Society of ClinicalOncology Breast Cancer CommitteeNCP-02 study conducted from September 16 to December 31,2021.The second survey was conducted from December 9 to December 26,2022,for those who had not received vaccines previously.In total,266 patients completed two questionnaires.A total of 143 patients(53.8%)changed their willingness to receive the vaccination.Among them,45,who were initially unwilling to be vaccinated,changed their stance to become hesitant and 15 changed to become willing.Among those with hesitant attitudes toward vaccines,45 changed their stance to become willing,and 28 changed to become unwilling;10 patients with willing attitudes toward vaccines changed to become hesitant.Those who received surgery(odds ratio(OR),4.24;95%confidence interval(CI),1.45–12.42;P=0.01)andwho lived with older adults or children(OR,2.03;95%CI,1.13–3.62;P=0.02)were more likely to change their attitudes toward COVID-19 vaccines.This finding suggested that patients with breast cancer were cautious about receiving the COVID-19 vaccine.Multiple methods should be used to promote vaccination and reduce vaccine hesitancy.
