Tomato(Solanum lycopersicum)has become a model for the study of fleshy fruits.Comprehending the regulatory mechanisms of fleshy fruit ripening is important.Transcription factors(TFs),hormones,and epigenetic regulation...Tomato(Solanum lycopersicum)has become a model for the study of fleshy fruits.Comprehending the regulatory mechanisms of fleshy fruit ripening is important.Transcription factors(TFs),hormones,and epigenetic regulation mainly regulate tomato fruit ripening,and the initiation of ripening requires ethylene and ripening-related TFs,such as NAC,MADS-box,RIN,GH3,HD-ZIP,and basic helix-loop-helix.In this review,we summarize recent research progress on these TFs in the regulation of tomato fruit ripening and highlight the crosstalk mechanisms of ethylene and ripening-related TFs.By affecting ethylene synthesis and signaling,TFs regulate softening and color changes in tomato fruits,thereby influencing fruit quality.Our review contributes to a systematic understanding of the regulatory mechanisms of tomato fruit ripening and provides a basis for developing or modeling complex ripening regulatory networks.展开更多
In the present study, we aimed to intensively study the chemical constituents, especially organic acids from a medicinal plant Portulaca oleracea L., and screen their anti-inflammatory and quinone reductase （QR, a ph...In the present study, we aimed to intensively study the chemical constituents, especially organic acids from a medicinal plant Portulaca oleracea L., and screen their anti-inflammatory and quinone reductase （QR, a phase II detoxyfication enzyme） inductive activity. A total of 20 compounds were isolated and identified based on spectroscopic methods, as succinic acid （1）, mono-methyl succinate （2）, L-malic acid （3）, L-l-methyl malate （4）, L-4-methyl malate （5）, L-dimethyl malate （6）, L-6-ethyl citrate （7）, L-1-methyl citrate （8）, L-1,5-dimethyl citrate （9）, 4-hydroxy-5-methylfuran-3-carboxylic acid （10）, 5-hydroxymethyl-furoic acid （11）, stearic acid （12）, L-pyroglutamic acid （13）, cyclo-（tyrosine-leucine） （14）, L-isoleucine （15）, （-）-dehydrovomifoliol （16）, （-）-epiloliolide （17）, 3,4-dihydroxyphenylethanol （18）, succinimide （19）, and uracil （20）. Among them, 14 compounds （2, 4-8, 10, 11, 13-18） were isolated from P. oleracea for the first time. Compotmd 18 （12.5 μM） exhibited potent anti-inflammatory effect in lipopolysaccharide （LPS）-induced macrophage cells （RAW264.7） by reducing NO production, and it also increased QR activity in Hepa lclc7 cells. Compound 16 （50 μM） showed weak QR inductive activity. None of other compounds showed anti-inflammatory or QR inductive activities.展开更多
Periodicity, anti-periodicity and almost periodicity are significant dynamic behaviors of time-varying neural networks. This paper researches the dynamics of anti-periodic solutions for a kind of inertial Quaternion-v...Periodicity, anti-periodicity and almost periodicity are significant dynamic behaviors of time-varying neural networks. This paper researches the dynamics of anti-periodic solutions for a kind of inertial Quaternion-valued Hopfield neural networks with varying-time delays.Without resolving the explored neural networks into real-valued systems, in the light of a continuation theorem of coincidence degree theory and inequality skills, by constructing different Lyapunov functions from those constructed in the existing research of the stability of equilibrium point, periodic solutions and anti-periodic solutions for neural networks, a newfangled sufficient condition insuring the existence of periodic solutions for above neural networks is gained. By constructing the same Lyapunov functions as those constructed in the proof of the existence of anti-periodic solutions, the newfangled asymptotic stability of anti-periodic solutions for above networks is acquired.展开更多
Bioactive glass-chitosan-alginate hybrid scaffolds （BG-C-A scaffolds） were fabricated using BG sol as a dual function additive, which behaves as both bioactive inorganic phase to confer the bioactivity and cross-lin...Bioactive glass-chitosan-alginate hybrid scaffolds （BG-C-A scaffolds） were fabricated using BG sol as a dual function additive, which behaves as both bioactive inorganic phase to confer the bioactivity and cross-linker to improve the structural stability and mechanical properties. The microstructure, physicochemical and mechanical properties, in vitro bioactivity and cellular biocompatibility of the scaffolds were investigated. The results indicated that BG component was successfully incorporated into the BG-C-A scaffolds through a facile BG sol-immersing method and the original interconnected microstructure could be well preserved. The obtained BG-C-A scaffolds showed improved mechanical properties and structural stability as compared to C-A scaffolds. At the same time, they presented excellent in vitro bioactivity and cellular compatibility. All these results demonstrated that these BG-C-A scaffolds have promising potential for tissue engineering.展开更多
Through the study of parse wood materials in Shandong Province, the fitting empirical equation of tree growth was obtained, a function with tree growth was a variable and time as an independent variable. Through mathe...Through the study of parse wood materials in Shandong Province, the fitting empirical equation of tree growth was obtained, a function with tree growth was a variable and time as an independent variable. Through mathematical operations such as function derivation, the mature age of tree growth was obtained. The obtained expected maturity age for Populus tomentosa forest was 11 a for pulp material, 26 a for pillar materials and 41 a for peeler. And the application, research directions and precautions of the mature ages were proposed.展开更多
The infiltration of glioblastoma multiforme(GBM)is predominantly characterized by diffuse spread,contributing significantly to therapy resistance and recurrence of GBM.In this study,we reveal that microtubule deacetyl...The infiltration of glioblastoma multiforme(GBM)is predominantly characterized by diffuse spread,contributing significantly to therapy resistance and recurrence of GBM.In this study,we reveal that microtubule deacetylation,mediated through the downregulation of fibronectin type III and SPRY domain-containing 1(FSD1),plays a pivotal role in promoting GBM diffuse infiltration.FSD1 directly interacts with histone deacetylase 6(HDAC6)at its second catalytic domain,thereby impeding its deacetylase activity onα-tubulin and preventing microtubule deacetylation and depolymerization.This inhibitory interaction is disrupted upon phosphorylation of FSD1 at its Ser317 and Ser324 residues by activated CDK5,leading to FSD1 dissociation from microtubules and facilitating HDAC6-mediatedα-tubulin deacetylation.Furthermore,increased expression of FSD1 or interference with FSD1 phosphorylation reduces microtubule deacetylation,suppresses invasion of GBM stem cells,and ultimately mitigates tumor infiltration in orthotopic GBM xenografts.Importantly,GBM tissues exhibit diminished levels of FSD1 expression,correlating with microtubule deacetylation and unfavorable clinical outcomes in GBM patients.These findings elucidate the mechanistic involvement of microtubule deacetylation in driving GBM cell invasion and offer potential avenues for managing GBM infiltration.展开更多
Brassinolides(BRs)are a kind of endogenous plant hormone that play an important role in regulating fruit ripening.BRs can regulate the process of fruit ripening by interacting with plant growth regulators and transcri...Brassinolides(BRs)are a kind of endogenous plant hormone that play an important role in regulating fruit ripening.BRs can regulate the process of fruit ripening by interacting with plant growth regulators and transcription factors.In this review,we discuss recent research advances on the role of BRs in fruit ripening and its relation to plant growth regulators and transcription factors.In addition,BR signaling molecules that are involved in fruit ripening and ripening-related genes are also highlighted.This review provides a better theoretical basis for improving fruit quality and regulating fruit ripening to speed up market availability,and for studying the mechanisms of BRs in fruit ripening.展开更多
The growth,development and pigment metabolism of Monascus are regulated by light.However,the function of the photoreceptor gene in the Monascus genome has not yet been clearly verified.In this paper,the gene sequence ...The growth,development and pigment metabolism of Monascus are regulated by light.However,the function of the photoreceptor gene in the Monascus genome has not yet been clearly verified.In this paper,the gene sequence Mphy,which is homologous to plant phytochrome,was firstly found from Monascus ruber C100 by comparing it with the genome.Then,taking M.ruber C100 as the main research object,by knocking out and overexpressing the Mphy gene,the involvement of Mphy in the regulation of light on the growth and development of Monascus and the metabolism of Monascus pigments(MPs)were preliminarily explored.Compared with the original strain C100,the Mphy knockout strain(ΔMphy)and the overexpression strain(OE-Mphy)grew slowly and produced low spores.At the same time,under different light conditions,red light can promote the growth and sporulation of Monascus,while blue light can inhibit it.MPs are positively regulated by the Mphy gene,that is,the deletion of the Mphy gene reduces the production of MPs,while the overexpression of the gene increases the accumulation of the pigment,especially under red light conditions.These results indicate that the homologous genes of phytochromes are involved in the process of light-regulated growth,development and pigment metabolism in Monascus.Based on the above results,we found that under red light conditions,Mphy controls the process of pigment metabolism by affecting key enzymes in TCA metabolism and key signaling pathways such as the MAPK signaling pathway.展开更多
Aiming at the problem of low yield of monascus yellow pigment liquid fermentation, a new process for producing yellow pigment by liquid fermentation of Monascus from potato has been designed. In this process, the colo...Aiming at the problem of low yield of monascus yellow pigment liquid fermentation, a new process for producing yellow pigment by liquid fermentation of Monascus from potato has been designed. In this process, the color value of intracellular yellow pigment reaches 341.2U/g, which is 58.73% higher than that of conventional liquid fermentation;the color value of extracellular yellow pigment reached 168U/g, which was 38.39% higher than that of conventional liquid fermentation. It was identified by liquid chromatography-mass spectrometry that the intracellular yellow pigments produced by this method were mainly Monascus and Monascus anka. The yields of these two pigments were increased by 33.91% and 84.32%, and their concentrations were 274.6 μg/mL and 167.1 μg/mL, respectively. In addition, the content of citrinin produced by the new process method was 97.85% lower than that of the original Monascus C100 strain and the fermentation broth has good stability. The electronic nose analysis of the fermentation broth indicated that the flavor substances were mainly alcohols and aldehydes and ketones. The antioxidant activity of the fermentation broth is good, for example: the reducing power is comparable to the reducing power of 350 μg/mL VC, the maximum DPPH free radical scavenging rate is 69.81%, the IC50 value of the superoxide anion free radical scavenging rate is 0.873 mL, ABTS The maximum free radical scavenging rate was comparable to the VC scavenging rate of 0.0035 mg/mL, and the maximum scavenging rate of hydroxyl radicals was 87.95%.展开更多
Background:Intestinal microcirculation is a critical interface for nutrient exchange and energy transfer,and is essential for maintaining physiological integrity.Our study aimed to elucidate the relationships among in...Background:Intestinal microcirculation is a critical interface for nutrient exchange and energy transfer,and is essential for maintaining physiological integrity.Our study aimed to elucidate the relationships among intestinal microhemodynamics,genetic background,sex,and microbial composition.Methods:To dissect the microhemodynamic landscape of the BALB/c,C57BL/6J,and KM mouse strains,laser Doppler flowmetry paired with wavelet transform analysis was utilized to determine the amplitude of characteristic oscillatory patterns.Microbial consortia were profiled using 16S rRNA gene sequencing.To augment our investigation,a broad-spectrum antibiotic regimen was administered to these strains to evaluate the impact of gut microbiota depletion on intestinal microhemodynamics.Immunohistochemical analyses were used to quantify platelet endothelial cell adhesion molecule-1(PECAM-1),estrogen receptorα(ESR1),and estrogen receptorβ(ESR2)expression.Results:Our findings revealed strain-dependent and sex-related disparities in microhemodynamic profiles and characteristic oscillatory behaviors.Significant differences in the gut microbiota contingent upon sex and genetic lineage were observed,with correlational analy-ses indicating an influence of the microbiota on microhemodynamic parameters.Following antibiotic treatment,distinct changes in blood perfusion levels and velocities were observed,including a reduction in female C57BL/6J mice and a general decrease in perfusion velocity.Enhanced erythrocyte aggregation and modulated endothelial function post-antibiotic treatment indicated that a systemic response to microbiota depletion impacted cardiac amplitude.Immunohistochemical data revealed strain-specific and sex-specific PECAM-1 and ESR1 expression patterns that aligned with observed intestinal microhemodynamic changes.Conclusions:This study highlights the influence of both genetic and sex-specific factors on intestinal microhemodynamics and the gut microbiota in mice.These findings also emphasize a substantial correlation between intestinal microhemodynamics and the compositional dynamics of the gut bacterial community.展开更多
Bioactive glasses （BGs） are ideal materials for macroporous scaffolds due to their excellent osteoconductive, osteoinductive, biocompatible and biodegradable properties, and their high bone bonding rates. Macroporou...Bioactive glasses （BGs） are ideal materials for macroporous scaffolds due to their excellent osteoconductive, osteoinductive, biocompatible and biodegradable properties, and their high bone bonding rates. Macroporous scaffolds made From BGs are in high demand for bone regeneration because they can stimulate vascularized bone ingrowth and they enhance bonding between scaffolds and surrounding tissues. Engineering BG/biopolymers （BP） composites or hybrids may be a good way to prepare macroporous scaffolds with excellent properties. This paper summarizes the progress in the past few years in preparing three-dimensional macroporous BG and BG/BP scaffolds for bone regeneration. Since the brittleness of BGs is a major problem in developing macroporous scaffolds and this limits their use in load bearing applications, the mechanical properties of macroporous scaffolds are particularly emphasized in this review.展开更多
基金supported by the National Natural Science Foundation of China(Grant Nos.32360743,32072559,31860568,31560563 and 31160398)the National Key Research and Development Program(Grant No.2018YFD1000800).
文摘Tomato(Solanum lycopersicum)has become a model for the study of fleshy fruits.Comprehending the regulatory mechanisms of fleshy fruit ripening is important.Transcription factors(TFs),hormones,and epigenetic regulation mainly regulate tomato fruit ripening,and the initiation of ripening requires ethylene and ripening-related TFs,such as NAC,MADS-box,RIN,GH3,HD-ZIP,and basic helix-loop-helix.In this review,we summarize recent research progress on these TFs in the regulation of tomato fruit ripening and highlight the crosstalk mechanisms of ethylene and ripening-related TFs.By affecting ethylene synthesis and signaling,TFs regulate softening and color changes in tomato fruits,thereby influencing fruit quality.Our review contributes to a systematic understanding of the regulatory mechanisms of tomato fruit ripening and provides a basis for developing or modeling complex ripening regulatory networks.
基金National Natural Science Foundation of China(Grant No.81073005)Science and Technology Development Program of Shandong Province(Grant No.2014GSF119007)+2 种基金Major Project of Science and Technology of Shandong Province(Grant No.2015ZDJS04001)Young Scholars Program of Shandong University(Grant No.YSPSDU2015WLJH50)China-Australia Centre for Health Sciences Research(2015)
文摘In the present study, we aimed to intensively study the chemical constituents, especially organic acids from a medicinal plant Portulaca oleracea L., and screen their anti-inflammatory and quinone reductase （QR, a phase II detoxyfication enzyme） inductive activity. A total of 20 compounds were isolated and identified based on spectroscopic methods, as succinic acid （1）, mono-methyl succinate （2）, L-malic acid （3）, L-l-methyl malate （4）, L-4-methyl malate （5）, L-dimethyl malate （6）, L-6-ethyl citrate （7）, L-1-methyl citrate （8）, L-1,5-dimethyl citrate （9）, 4-hydroxy-5-methylfuran-3-carboxylic acid （10）, 5-hydroxymethyl-furoic acid （11）, stearic acid （12）, L-pyroglutamic acid （13）, cyclo-（tyrosine-leucine） （14）, L-isoleucine （15）, （-）-dehydrovomifoliol （16）, （-）-epiloliolide （17）, 3,4-dihydroxyphenylethanol （18）, succinimide （19）, and uracil （20）. Among them, 14 compounds （2, 4-8, 10, 11, 13-18） were isolated from P. oleracea for the first time. Compotmd 18 （12.5 μM） exhibited potent anti-inflammatory effect in lipopolysaccharide （LPS）-induced macrophage cells （RAW264.7） by reducing NO production, and it also increased QR activity in Hepa lclc7 cells. Compound 16 （50 μM） showed weak QR inductive activity. None of other compounds showed anti-inflammatory or QR inductive activities.
基金Supported by the Basic Research Expenses for Provincial Colleges and Universities(Grant No.JYT2020030)。
文摘Periodicity, anti-periodicity and almost periodicity are significant dynamic behaviors of time-varying neural networks. This paper researches the dynamics of anti-periodic solutions for a kind of inertial Quaternion-valued Hopfield neural networks with varying-time delays.Without resolving the explored neural networks into real-valued systems, in the light of a continuation theorem of coincidence degree theory and inequality skills, by constructing different Lyapunov functions from those constructed in the existing research of the stability of equilibrium point, periodic solutions and anti-periodic solutions for neural networks, a newfangled sufficient condition insuring the existence of periodic solutions for above neural networks is gained. By constructing the same Lyapunov functions as those constructed in the proof of the existence of anti-periodic solutions, the newfangled asymptotic stability of anti-periodic solutions for above networks is acquired.
基金supported by the National Natural Science Foundation of China(No. 51773209)the National Basic Research Program(No. 2017YFC1103300)the Strategic Priority Research Program of Chinese Academy of Sciences(No. XDB12020300)
文摘Bioactive glass-chitosan-alginate hybrid scaffolds （BG-C-A scaffolds） were fabricated using BG sol as a dual function additive, which behaves as both bioactive inorganic phase to confer the bioactivity and cross-linker to improve the structural stability and mechanical properties. The microstructure, physicochemical and mechanical properties, in vitro bioactivity and cellular biocompatibility of the scaffolds were investigated. The results indicated that BG component was successfully incorporated into the BG-C-A scaffolds through a facile BG sol-immersing method and the original interconnected microstructure could be well preserved. The obtained BG-C-A scaffolds showed improved mechanical properties and structural stability as compared to C-A scaffolds. At the same time, they presented excellent in vitro bioactivity and cellular compatibility. All these results demonstrated that these BG-C-A scaffolds have promising potential for tissue engineering.
文摘Through the study of parse wood materials in Shandong Province, the fitting empirical equation of tree growth was obtained, a function with tree growth was a variable and time as an independent variable. Through mathematical operations such as function derivation, the mature age of tree growth was obtained. The obtained expected maturity age for Populus tomentosa forest was 11 a for pulp material, 26 a for pillar materials and 41 a for peeler. And the application, research directions and precautions of the mature ages were proposed.
基金supported by the National Key Research and Development Program of China(2022YFA1303000,2017YFA0505602)the National Natural Science Foundation of China(81872408,81872153).
文摘The infiltration of glioblastoma multiforme(GBM)is predominantly characterized by diffuse spread,contributing significantly to therapy resistance and recurrence of GBM.In this study,we reveal that microtubule deacetylation,mediated through the downregulation of fibronectin type III and SPRY domain-containing 1(FSD1),plays a pivotal role in promoting GBM diffuse infiltration.FSD1 directly interacts with histone deacetylase 6(HDAC6)at its second catalytic domain,thereby impeding its deacetylase activity onα-tubulin and preventing microtubule deacetylation and depolymerization.This inhibitory interaction is disrupted upon phosphorylation of FSD1 at its Ser317 and Ser324 residues by activated CDK5,leading to FSD1 dissociation from microtubules and facilitating HDAC6-mediatedα-tubulin deacetylation.Furthermore,increased expression of FSD1 or interference with FSD1 phosphorylation reduces microtubule deacetylation,suppresses invasion of GBM stem cells,and ultimately mitigates tumor infiltration in orthotopic GBM xenografts.Importantly,GBM tissues exhibit diminished levels of FSD1 expression,correlating with microtubule deacetylation and unfavorable clinical outcomes in GBM patients.These findings elucidate the mechanistic involvement of microtubule deacetylation in driving GBM cell invasion and offer potential avenues for managing GBM infiltration.
基金the National Natural Science Foundation of China(Nos.32360743,32072559,31860568,31560563,and 31160398)the Key Research and Development Program of Gansu Province,China(No.21YF5WA096)+2 种基金the National Key Research and Development Program(No.2018YFD1000800)the Research Fund of Higher Education of Gansu,China(Nos.2018C-14 and 2019B-082)the Natural Science Foundation of Gansu Province,China(No.1606RJZA073).
文摘Brassinolides(BRs)are a kind of endogenous plant hormone that play an important role in regulating fruit ripening.BRs can regulate the process of fruit ripening by interacting with plant growth regulators and transcription factors.In this review,we discuss recent research advances on the role of BRs in fruit ripening and its relation to plant growth regulators and transcription factors.In addition,BR signaling molecules that are involved in fruit ripening and ripening-related genes are also highlighted.This review provides a better theoretical basis for improving fruit quality and regulating fruit ripening to speed up market availability,and for studying the mechanisms of BRs in fruit ripening.
文摘The growth,development and pigment metabolism of Monascus are regulated by light.However,the function of the photoreceptor gene in the Monascus genome has not yet been clearly verified.In this paper,the gene sequence Mphy,which is homologous to plant phytochrome,was firstly found from Monascus ruber C100 by comparing it with the genome.Then,taking M.ruber C100 as the main research object,by knocking out and overexpressing the Mphy gene,the involvement of Mphy in the regulation of light on the growth and development of Monascus and the metabolism of Monascus pigments(MPs)were preliminarily explored.Compared with the original strain C100,the Mphy knockout strain(ΔMphy)and the overexpression strain(OE-Mphy)grew slowly and produced low spores.At the same time,under different light conditions,red light can promote the growth and sporulation of Monascus,while blue light can inhibit it.MPs are positively regulated by the Mphy gene,that is,the deletion of the Mphy gene reduces the production of MPs,while the overexpression of the gene increases the accumulation of the pigment,especially under red light conditions.These results indicate that the homologous genes of phytochromes are involved in the process of light-regulated growth,development and pigment metabolism in Monascus.Based on the above results,we found that under red light conditions,Mphy controls the process of pigment metabolism by affecting key enzymes in TCA metabolism and key signaling pathways such as the MAPK signaling pathway.
文摘Aiming at the problem of low yield of monascus yellow pigment liquid fermentation, a new process for producing yellow pigment by liquid fermentation of Monascus from potato has been designed. In this process, the color value of intracellular yellow pigment reaches 341.2U/g, which is 58.73% higher than that of conventional liquid fermentation;the color value of extracellular yellow pigment reached 168U/g, which was 38.39% higher than that of conventional liquid fermentation. It was identified by liquid chromatography-mass spectrometry that the intracellular yellow pigments produced by this method were mainly Monascus and Monascus anka. The yields of these two pigments were increased by 33.91% and 84.32%, and their concentrations were 274.6 μg/mL and 167.1 μg/mL, respectively. In addition, the content of citrinin produced by the new process method was 97.85% lower than that of the original Monascus C100 strain and the fermentation broth has good stability. The electronic nose analysis of the fermentation broth indicated that the flavor substances were mainly alcohols and aldehydes and ketones. The antioxidant activity of the fermentation broth is good, for example: the reducing power is comparable to the reducing power of 350 μg/mL VC, the maximum DPPH free radical scavenging rate is 69.81%, the IC50 value of the superoxide anion free radical scavenging rate is 0.873 mL, ABTS The maximum free radical scavenging rate was comparable to the VC scavenging rate of 0.0035 mg/mL, and the maximum scavenging rate of hydroxyl radicals was 87.95%.
基金supported by the CAMS Innovation Fund for Medical Sciences[2022-I2M-1-026]the Beijing Municipal Natural Science Foundation[No.7212068]the National Natural Science Foundation of China[No.81900747].
文摘Background:Intestinal microcirculation is a critical interface for nutrient exchange and energy transfer,and is essential for maintaining physiological integrity.Our study aimed to elucidate the relationships among intestinal microhemodynamics,genetic background,sex,and microbial composition.Methods:To dissect the microhemodynamic landscape of the BALB/c,C57BL/6J,and KM mouse strains,laser Doppler flowmetry paired with wavelet transform analysis was utilized to determine the amplitude of characteristic oscillatory patterns.Microbial consortia were profiled using 16S rRNA gene sequencing.To augment our investigation,a broad-spectrum antibiotic regimen was administered to these strains to evaluate the impact of gut microbiota depletion on intestinal microhemodynamics.Immunohistochemical analyses were used to quantify platelet endothelial cell adhesion molecule-1(PECAM-1),estrogen receptorα(ESR1),and estrogen receptorβ(ESR2)expression.Results:Our findings revealed strain-dependent and sex-related disparities in microhemodynamic profiles and characteristic oscillatory behaviors.Significant differences in the gut microbiota contingent upon sex and genetic lineage were observed,with correlational analy-ses indicating an influence of the microbiota on microhemodynamic parameters.Following antibiotic treatment,distinct changes in blood perfusion levels and velocities were observed,including a reduction in female C57BL/6J mice and a general decrease in perfusion velocity.Enhanced erythrocyte aggregation and modulated endothelial function post-antibiotic treatment indicated that a systemic response to microbiota depletion impacted cardiac amplitude.Immunohistochemical data revealed strain-specific and sex-specific PECAM-1 and ESR1 expression patterns that aligned with observed intestinal microhemodynamic changes.Conclusions:This study highlights the influence of both genetic and sex-specific factors on intestinal microhemodynamics and the gut microbiota in mice.These findings also emphasize a substantial correlation between intestinal microhemodynamics and the compositional dynamics of the gut bacterial community.
文摘Bioactive glasses （BGs） are ideal materials for macroporous scaffolds due to their excellent osteoconductive, osteoinductive, biocompatible and biodegradable properties, and their high bone bonding rates. Macroporous scaffolds made From BGs are in high demand for bone regeneration because they can stimulate vascularized bone ingrowth and they enhance bonding between scaffolds and surrounding tissues. Engineering BG/biopolymers （BP） composites or hybrids may be a good way to prepare macroporous scaffolds with excellent properties. This paper summarizes the progress in the past few years in preparing three-dimensional macroporous BG and BG/BP scaffolds for bone regeneration. Since the brittleness of BGs is a major problem in developing macroporous scaffolds and this limits their use in load bearing applications, the mechanical properties of macroporous scaffolds are particularly emphasized in this review.
