Two new cytochalasans,xylariaides A(1)and B(2),were isolated and identified from a soil fungus Xylaria sp.Y01.Their structures were unambiguously determined by extensive spectroscopic methods including high resolution...Two new cytochalasans,xylariaides A(1)and B(2),were isolated and identified from a soil fungus Xylaria sp.Y01.Their structures were unambiguously determined by extensive spectroscopic methods including high resolution electro-spray ionization mass spectrometry,ultraviolet radiation,infrared spectroscopy,and 1D/2D NMR,as well as in-depth quantum chemical calculations of gauge-including atomic orbital(GIAO)^(13)C NMR chemical shifts,electronic circular dichroism(ECD),and spin-spin coupling constants.The unprecedented core structure with a 5/6/5/3 fused tetracyclic ring system further enriches the scaffold types of cytochalasans.展开更多
基金supported by National Natural Science Foundation of China(82173713)Key Research and Development Program of Hunan Province(2022SK2031)+2 种基金Natural Science Foundation of Hunan Province(2024JJ8127)Project of Hunan Administration of Traditional Chinese Medicine(B2023059)Changsha Municipal Natural Science Foundation(kq2403041).
文摘Two new cytochalasans,xylariaides A(1)and B(2),were isolated and identified from a soil fungus Xylaria sp.Y01.Their structures were unambiguously determined by extensive spectroscopic methods including high resolution electro-spray ionization mass spectrometry,ultraviolet radiation,infrared spectroscopy,and 1D/2D NMR,as well as in-depth quantum chemical calculations of gauge-including atomic orbital(GIAO)^(13)C NMR chemical shifts,electronic circular dichroism(ECD),and spin-spin coupling constants.The unprecedented core structure with a 5/6/5/3 fused tetracyclic ring system further enriches the scaffold types of cytochalasans.
