Artificial intelligence(AI)technology is expanding at a rapid pace,offering means of improving the precision of judgments made by medical professionals.AI-driven machine learning(ML)facilitates rapid and effective dat...Artificial intelligence(AI)technology is expanding at a rapid pace,offering means of improving the precision of judgments made by medical professionals.AI-driven machine learning(ML)facilitates rapid and effective data processing for diagnosis and treatment of different diseases including stroke.This technology has vastly improved the patient classification based on their predicted stroke outcome.It helps in quicker decision-making,improves diagnosis precision,and enhances patient care.ML techniques have occasionally been applied extensively to address complex issues related to stroke such as the prediction of stroke prevalence at an early stage.The ability of deep learning(DL)algorithms,a crucial element of AI,is becoming popular in stroke imaging analysis because it automatically extracts features without requiring domain expertise.In the preclinical setup for stroke studies,ML/DL models are commendably used for the detection of vascular thrombi,stroke core,and penumbra size,to identify artery occlusion,compute perfusion maps,detect intracranial hemorrhage(ICH),prediction of infarct,assessing the severity of hemorrhagic transformation,and forecasting patient outcomes.The robust automatic data processing,excellent generalization,self-learning,and precise decision-making abilities of such models have contributed immensely to the advancement of stroke therapy.In the preclinical setup,the time-investing behavioral studies of the animals are also effectively analyzed by AI based algorithms.Understanding the algorithms and models based on AI is yet to be simplified for its appli-cation in stroke therapy in present clinical settings,thus,in the present review attempts have been made to present it in a simplified manner to facilitate translation.展开更多
Date Rape Drugs are the members of tranquilizers and sedative class of drugs.These are the substances that make it easier for someone to rape or assault sexually.The person who is administrated by these drugs can caus...Date Rape Drugs are the members of tranquilizers and sedative class of drugs.These are the substances that make it easier for someone to rape or assault sexually.The person who is administrated by these drugs can cause sleepiness,slow breathing,slow heartbeat rate,trouble in muscle coordination,loss of consciousness.GHB(gamma-hydroxybutyric acid),Rohypnol(flunitrazepam),Ketamine are generally considered as date rape drugs.As Food and Drug Administration Department of Central Government of India considered this issue and placed these drugs under the schedule of Narcotic Drugs and Psychotropic Substances Act.Thereafter it is nearly impossible to get these drugs easily.But criminals have been searched new way through it.Normal tranquilizers and sedatives are also being used for committing such crimes.These drugs are also scheduled,but one can get them with prescription from a registered medical practitioner.So we carried out a comparative study of 3 tranquilizers from the benzodiazepine class that are Diazepam,Alprazolam,and Librium to check their dissolving rate in stomach acid.Estimation of action time of drug can help an investigator to identify the class of drug and time of drug injected(early phase).In our study,we found that the dissolving period of Diazepam and Alprazolam is more than conventional drugs.展开更多
基金Department of Pharmaceuticals Ministry of Chemicals and Fertilizer,Government of India and National Institute of Pharmaceutical Education and Research(NIPER)Ahmedabad,Gandhinagar,India。
文摘Artificial intelligence(AI)technology is expanding at a rapid pace,offering means of improving the precision of judgments made by medical professionals.AI-driven machine learning(ML)facilitates rapid and effective data processing for diagnosis and treatment of different diseases including stroke.This technology has vastly improved the patient classification based on their predicted stroke outcome.It helps in quicker decision-making,improves diagnosis precision,and enhances patient care.ML techniques have occasionally been applied extensively to address complex issues related to stroke such as the prediction of stroke prevalence at an early stage.The ability of deep learning(DL)algorithms,a crucial element of AI,is becoming popular in stroke imaging analysis because it automatically extracts features without requiring domain expertise.In the preclinical setup for stroke studies,ML/DL models are commendably used for the detection of vascular thrombi,stroke core,and penumbra size,to identify artery occlusion,compute perfusion maps,detect intracranial hemorrhage(ICH),prediction of infarct,assessing the severity of hemorrhagic transformation,and forecasting patient outcomes.The robust automatic data processing,excellent generalization,self-learning,and precise decision-making abilities of such models have contributed immensely to the advancement of stroke therapy.In the preclinical setup,the time-investing behavioral studies of the animals are also effectively analyzed by AI based algorithms.Understanding the algorithms and models based on AI is yet to be simplified for its appli-cation in stroke therapy in present clinical settings,thus,in the present review attempts have been made to present it in a simplified manner to facilitate translation.
文摘Date Rape Drugs are the members of tranquilizers and sedative class of drugs.These are the substances that make it easier for someone to rape or assault sexually.The person who is administrated by these drugs can cause sleepiness,slow breathing,slow heartbeat rate,trouble in muscle coordination,loss of consciousness.GHB(gamma-hydroxybutyric acid),Rohypnol(flunitrazepam),Ketamine are generally considered as date rape drugs.As Food and Drug Administration Department of Central Government of India considered this issue and placed these drugs under the schedule of Narcotic Drugs and Psychotropic Substances Act.Thereafter it is nearly impossible to get these drugs easily.But criminals have been searched new way through it.Normal tranquilizers and sedatives are also being used for committing such crimes.These drugs are also scheduled,but one can get them with prescription from a registered medical practitioner.So we carried out a comparative study of 3 tranquilizers from the benzodiazepine class that are Diazepam,Alprazolam,and Librium to check their dissolving rate in stomach acid.Estimation of action time of drug can help an investigator to identify the class of drug and time of drug injected(early phase).In our study,we found that the dissolving period of Diazepam and Alprazolam is more than conventional drugs.
