Genus Prunus comprising around 430 species is a vast important genus of family Rosaceae, subfamily amygdalaoidae. Among all 430 species, around 19 important species are commonly found in Indian subcontinent due to the...Genus Prunus comprising around 430 species is a vast important genus of family Rosaceae, subfamily amygdalaoidae. Among all 430 species, around 19 important species are commonly found in Indian subcontinent due to their broad nutritional and economic importance. Some most common species of genus Prunus are Prunus amygdalus, Prunus persica, Prunus armeniaca, Prunus avium, Prunus cerasus, Prunus cerasoides, Prunus domestica, Prunus mahaleb, etc. A newly introduced species of Prunus i.e Prunus sunhangii is recently discovered which is morphologically very similar to Prunus cerasoides. Plants of Prunus species are short to medium-sized deciduous trees mainly found in the northern hemisphere. In India and its subcontinent,it extends from the Himalayas to Sikkim, Meghalaya,Bhutan, Myanmar etc. Different Prunus species have been extensively studied for their morphological,microscopic, pharmacological and phytoconstituents characteristics. Total phenolic content of Prunus species explains the presence of phenols in high quantity and pharmacological activity due to phenols. Phytochemical screening of species of genus Prunus shows the presence of wide phytoconstituents which contributes in their pharmacological significance and reveals the therapeutic potential and traditional medicinal significance of this genus. Genus Prunus showed a potent antioxidant activity analyzed by 1,1-diphenyl-2-picryl-hydrazyl radical assay. Plant species belonging to the genus Prunus is widely used traditionally for the treatment of various disorders. Some specific Prunus species possess potent anticancer, anti-inflammatory,hypoglycemic etc. activity which makes the genus more interesting for further research and findings. This review is an attempt to summarize the comprehensive study of Prunus species from its distribution, morphological characters to phytoconstituents, and pharmacological activity.展开更多
The objective of this study was to compare ecophysiological and morphological parameters of a regionally endangered orchid species,Epipactis atrorubens(Hoffm.ex Bernh.)Bess.,growing in two forest communities(on serpen...The objective of this study was to compare ecophysiological and morphological parameters of a regionally endangered orchid species,Epipactis atrorubens(Hoffm.ex Bernh.)Bess.,growing in two forest communities(on serpentine and granite outcrops)of the Middle Urals,Russia.Biodiversity,dominance,and phytocoenosis studies showed the colonization of a wide range of plant species on both sites.The physicochemical properties of the soil,chemical composition and morphological features of E.atrorubens,growing under technogenic conditions(asbestos deposits),on serpentine outcrops and in the natural environment of the granite massif were studied for the first time.The serpentine substrate differed from the granite one by its greater stoniness,circumneutral pH and lower contents of available nitrogen and phosphorus.Extremely high concentrations of magnesium were found in the serpentine soil,some 79 times higher than in the granite substrate.High concentrations of nickel(94 times),chromium(59 times),cobalt(17 times),and iron(4 times)were found in the serpentine substrate,higher than in the granite substrate.The differences between the sites for available metal contents and for root and shoot metal contents were significantly less.Concentrations of most of the metals in the roots were higher than in the shoots.Despite higher metal concentrations and lower nitrogen and phosphorus levels in serpentine soils,E.atrorubens had a larger population and greater viability compared to those growing on granite.Plants on serpentine outcrops were characterized by the formation of a larger number of fruits,greater root lengths and thicker leaf blades,compared to plants on granites.The well-developed orchid mycorrhizae contributed to the survival of this species under unfavorable serpentine conditions.Hence,serpentine outcrops formed due to the mining of asbestos could be a suitable substrate for the light-demanding E.atrorubens due to its capacity to adapt to dry,rocky,nutrient-depleted soils and limited competition from other plants.展开更多
Water injection has shown to be one of the most successful,efficient,and cost-effective reservoir management strategies.By re-injecting treated and filtered water into reservoirs,this approach can help maintain reserv...Water injection has shown to be one of the most successful,efficient,and cost-effective reservoir management strategies.By re-injecting treated and filtered water into reservoirs,this approach can help maintain reservoir pressure,increase hydrocarbon output,and reduce the environmental effect.The goal of this project is to create a water injection model utilizing Eclipse reservoir simulation software to better understand water injection methods for reservoir pressure maintenance.A basic reservoir model is utilized in this investigation.For simulation designs,the reservoir length,breadth,and thickness may be changed to different levels.The water-oil contact was discovered at 7000 feet,and the reservoir pressure was recorded at 3000 pounds per square inch at a depth of 6900 feet.The aquifer chosen was of the Fetkovich type and was linked to the reservoir in the j+direction.The porosity was estimated to be varied,ranging from 9%to 16%.The residual oil saturation was set to 25%and the irreducible water saturation was set at 20%.The vertical permeability was set at 50 md as a constant.Pressure Volume Temperature(PVT)data was used to estimate the gas and water characteristics.展开更多
Cattle are the backbone of household economy in rural areas of India and many of them die after bites by potentially rabid dogs, despite being given currently recommended five shots of intramuscular (IM) rabies vaccin...Cattle are the backbone of household economy in rural areas of India and many of them die after bites by potentially rabid dogs, despite being given currently recommended five shots of intramuscular (IM) rabies vaccination as Post Exposure Prophylaxis (PEP). In 2016, seven of 21 bovine bitten by rabid dogs given IM rabies vaccination died due to rabies in Shimla Municipality. This scenario prompted the authors to look for a suitable protocol, based on human studies, to save animals. We tested various schedules of IDRV in bovine and found that a schedule of 0.2 ml given in middle 1/3rd of neck on day 0, 3, 7, 14 and 28 along with local wound infiltration of eRIG is sufficiently immunogenic and life saving in all of them, even if bitten by lab confirmed rabid dogs/mongoose as tested by CRI. Rabivac Vet, a Cell Culture Rabies Vaccine, available as 1 ml per vial was used off level for IDRV. While injecting the vaccine, a raised papule of ≥1 cm will appear slowly causing a peau d’orange appearance. All 60 bovine serum samples tested by RFFIT after IDRV, had titers more than 0.5 IU/ml on day 14. Thereafter, a total of 150 animals were given five doses of IDRV as PEP, with or without RIG, after their exposure to clinically or lab confirmed rabid dogs/mongoose and all survived for more than a year. Serum samples from 15 animals bitten by lab confirmed rabid dogs/mongoose were collected on day 14 and tested for RVNA by RFFIT from NIMHANS Bangalore and all had desired antibody titers above 0.5 IU/ml, without any immunosuppression. The RFFIT titers in 55% bovine in all groups were more than adequate after one year and 100% of them had anamnestic response to a single 0.2 ml booster given at one year. Few of the bovine and even one equine (Horse. Figure 4) brought for PEP at some of nearby vet hospitals were given IM rabies vaccine with local eRIG infiltration also survived. Local eRIG infiltration appeared to have covered the lacuna of longer window period required for indigenous antibodies production through IM route in bovine that are not sufficiently produced by day 14. While five times less vaccine was used in this low cost protocol and the survival was 100% compared to traditional IM protocol where survival was 66%. Pre-exposure prophylaxis was found to be effective as 0.2 ml dose of IDRV on day 0, 3, 7 and all bovine had titers higher than the desired by day seven after single 0.2 ml vaccine booster at one year. Our study points towards a possibility of having short schedules of three shots IDRV vaccination in bovine with or without local RIG (depending on presence or absence of wound/s) as PEP and single shot IDRV as PrEP, but further studies are required on a large number of animals. Our study also points out for allowing intra-dermal use in animals as well and labeling vaccines for the same as this is low cost more immunogenic and less painful compare to IM administration.展开更多
Thyroid abnormalities have been reported in persons with HIV infection, although data have been inconsistent with respect to its frequency and association with specific medications. The purpose of this study was to ex...Thyroid abnormalities have been reported in persons with HIV infection, although data have been inconsistent with respect to its frequency and association with specific medications. The purpose of this study was to explore thyroid system response to thyroid releasing hormone stimulation in persons with and without HIV infection and determine the extent to which their response was associated with depression. As part of a larger study of neuroendocrine response persons with HIV-1 infection, control and HIV-1 infected individuals were evaluated. Participants' response to TRH stimulation was evaluated via TSH, total T3, and T4 levels at baseline and 15, 30, 45, and 60 minutes after TRH stimulation. Participants with HIV infection had a more robust response to TRH stimulation as measured by higher levels of TSH, lower levels of T4 and modestly higher levels of T3. Depressed persons had a reduced TSH response to stimulation and lower levels of both T4 and T3, although the effect of depression on T4 was not statistically significant. These results suggest that TSH response to TRH-stimulation may be exaggerated in individuals with HIV infection but reduced in those with depression. They also suggest that the effects of depression and HIV infection may interact, and may provide a partial explanation for observed thyroid abnormalities in HIV-infected individuals. Results thus provide a partial explanation for findings on thyroid and depression in those affected by HIV infection.展开更多
文摘Genus Prunus comprising around 430 species is a vast important genus of family Rosaceae, subfamily amygdalaoidae. Among all 430 species, around 19 important species are commonly found in Indian subcontinent due to their broad nutritional and economic importance. Some most common species of genus Prunus are Prunus amygdalus, Prunus persica, Prunus armeniaca, Prunus avium, Prunus cerasus, Prunus cerasoides, Prunus domestica, Prunus mahaleb, etc. A newly introduced species of Prunus i.e Prunus sunhangii is recently discovered which is morphologically very similar to Prunus cerasoides. Plants of Prunus species are short to medium-sized deciduous trees mainly found in the northern hemisphere. In India and its subcontinent,it extends from the Himalayas to Sikkim, Meghalaya,Bhutan, Myanmar etc. Different Prunus species have been extensively studied for their morphological,microscopic, pharmacological and phytoconstituents characteristics. Total phenolic content of Prunus species explains the presence of phenols in high quantity and pharmacological activity due to phenols. Phytochemical screening of species of genus Prunus shows the presence of wide phytoconstituents which contributes in their pharmacological significance and reveals the therapeutic potential and traditional medicinal significance of this genus. Genus Prunus showed a potent antioxidant activity analyzed by 1,1-diphenyl-2-picryl-hydrazyl radical assay. Plant species belonging to the genus Prunus is widely used traditionally for the treatment of various disorders. Some specific Prunus species possess potent anticancer, anti-inflammatory,hypoglycemic etc. activity which makes the genus more interesting for further research and findings. This review is an attempt to summarize the comprehensive study of Prunus species from its distribution, morphological characters to phytoconstituents, and pharmacological activity.
文摘The objective of this study was to compare ecophysiological and morphological parameters of a regionally endangered orchid species,Epipactis atrorubens(Hoffm.ex Bernh.)Bess.,growing in two forest communities(on serpentine and granite outcrops)of the Middle Urals,Russia.Biodiversity,dominance,and phytocoenosis studies showed the colonization of a wide range of plant species on both sites.The physicochemical properties of the soil,chemical composition and morphological features of E.atrorubens,growing under technogenic conditions(asbestos deposits),on serpentine outcrops and in the natural environment of the granite massif were studied for the first time.The serpentine substrate differed from the granite one by its greater stoniness,circumneutral pH and lower contents of available nitrogen and phosphorus.Extremely high concentrations of magnesium were found in the serpentine soil,some 79 times higher than in the granite substrate.High concentrations of nickel(94 times),chromium(59 times),cobalt(17 times),and iron(4 times)were found in the serpentine substrate,higher than in the granite substrate.The differences between the sites for available metal contents and for root and shoot metal contents were significantly less.Concentrations of most of the metals in the roots were higher than in the shoots.Despite higher metal concentrations and lower nitrogen and phosphorus levels in serpentine soils,E.atrorubens had a larger population and greater viability compared to those growing on granite.Plants on serpentine outcrops were characterized by the formation of a larger number of fruits,greater root lengths and thicker leaf blades,compared to plants on granites.The well-developed orchid mycorrhizae contributed to the survival of this species under unfavorable serpentine conditions.Hence,serpentine outcrops formed due to the mining of asbestos could be a suitable substrate for the light-demanding E.atrorubens due to its capacity to adapt to dry,rocky,nutrient-depleted soils and limited competition from other plants.
文摘Water injection has shown to be one of the most successful,efficient,and cost-effective reservoir management strategies.By re-injecting treated and filtered water into reservoirs,this approach can help maintain reservoir pressure,increase hydrocarbon output,and reduce the environmental effect.The goal of this project is to create a water injection model utilizing Eclipse reservoir simulation software to better understand water injection methods for reservoir pressure maintenance.A basic reservoir model is utilized in this investigation.For simulation designs,the reservoir length,breadth,and thickness may be changed to different levels.The water-oil contact was discovered at 7000 feet,and the reservoir pressure was recorded at 3000 pounds per square inch at a depth of 6900 feet.The aquifer chosen was of the Fetkovich type and was linked to the reservoir in the j+direction.The porosity was estimated to be varied,ranging from 9%to 16%.The residual oil saturation was set to 25%and the irreducible water saturation was set at 20%.The vertical permeability was set at 50 md as a constant.Pressure Volume Temperature(PVT)data was used to estimate the gas and water characteristics.
文摘Cattle are the backbone of household economy in rural areas of India and many of them die after bites by potentially rabid dogs, despite being given currently recommended five shots of intramuscular (IM) rabies vaccination as Post Exposure Prophylaxis (PEP). In 2016, seven of 21 bovine bitten by rabid dogs given IM rabies vaccination died due to rabies in Shimla Municipality. This scenario prompted the authors to look for a suitable protocol, based on human studies, to save animals. We tested various schedules of IDRV in bovine and found that a schedule of 0.2 ml given in middle 1/3rd of neck on day 0, 3, 7, 14 and 28 along with local wound infiltration of eRIG is sufficiently immunogenic and life saving in all of them, even if bitten by lab confirmed rabid dogs/mongoose as tested by CRI. Rabivac Vet, a Cell Culture Rabies Vaccine, available as 1 ml per vial was used off level for IDRV. While injecting the vaccine, a raised papule of ≥1 cm will appear slowly causing a peau d’orange appearance. All 60 bovine serum samples tested by RFFIT after IDRV, had titers more than 0.5 IU/ml on day 14. Thereafter, a total of 150 animals were given five doses of IDRV as PEP, with or without RIG, after their exposure to clinically or lab confirmed rabid dogs/mongoose and all survived for more than a year. Serum samples from 15 animals bitten by lab confirmed rabid dogs/mongoose were collected on day 14 and tested for RVNA by RFFIT from NIMHANS Bangalore and all had desired antibody titers above 0.5 IU/ml, without any immunosuppression. The RFFIT titers in 55% bovine in all groups were more than adequate after one year and 100% of them had anamnestic response to a single 0.2 ml booster given at one year. Few of the bovine and even one equine (Horse. Figure 4) brought for PEP at some of nearby vet hospitals were given IM rabies vaccine with local eRIG infiltration also survived. Local eRIG infiltration appeared to have covered the lacuna of longer window period required for indigenous antibodies production through IM route in bovine that are not sufficiently produced by day 14. While five times less vaccine was used in this low cost protocol and the survival was 100% compared to traditional IM protocol where survival was 66%. Pre-exposure prophylaxis was found to be effective as 0.2 ml dose of IDRV on day 0, 3, 7 and all bovine had titers higher than the desired by day seven after single 0.2 ml vaccine booster at one year. Our study points towards a possibility of having short schedules of three shots IDRV vaccination in bovine with or without local RIG (depending on presence or absence of wound/s) as PEP and single shot IDRV as PrEP, but further studies are required on a large number of animals. Our study also points out for allowing intra-dermal use in animals as well and labeling vaccines for the same as this is low cost more immunogenic and less painful compare to IM administration.
文摘Thyroid abnormalities have been reported in persons with HIV infection, although data have been inconsistent with respect to its frequency and association with specific medications. The purpose of this study was to explore thyroid system response to thyroid releasing hormone stimulation in persons with and without HIV infection and determine the extent to which their response was associated with depression. As part of a larger study of neuroendocrine response persons with HIV-1 infection, control and HIV-1 infected individuals were evaluated. Participants' response to TRH stimulation was evaluated via TSH, total T3, and T4 levels at baseline and 15, 30, 45, and 60 minutes after TRH stimulation. Participants with HIV infection had a more robust response to TRH stimulation as measured by higher levels of TSH, lower levels of T4 and modestly higher levels of T3. Depressed persons had a reduced TSH response to stimulation and lower levels of both T4 and T3, although the effect of depression on T4 was not statistically significant. These results suggest that TSH response to TRH-stimulation may be exaggerated in individuals with HIV infection but reduced in those with depression. They also suggest that the effects of depression and HIV infection may interact, and may provide a partial explanation for observed thyroid abnormalities in HIV-infected individuals. Results thus provide a partial explanation for findings on thyroid and depression in those affected by HIV infection.
