The anticancer effect of chemotherapy has been historically attributed to directly inducing proliferating cancer cell death.1 Accumulating evidence suggests that chemotherapy also engages the immune system.Some chemot...The anticancer effect of chemotherapy has been historically attributed to directly inducing proliferating cancer cell death.1 Accumulating evidence suggests that chemotherapy also engages the immune system.Some chemotherapies can induce immunogenic cell death,leading to tumor antigen uptake and presentation by dendritic cells to activate tumor-reactive T cells.2 A new study by Wang et al.adds another dimension to this paradigm by demonstrating that chemotherapy pretreatment of cancer cells can directly activate virtual memory(VM)CD8^(+)T cells to mediate tumor cytotoxicity in an antigen-independent manner.展开更多
文摘The anticancer effect of chemotherapy has been historically attributed to directly inducing proliferating cancer cell death.1 Accumulating evidence suggests that chemotherapy also engages the immune system.Some chemotherapies can induce immunogenic cell death,leading to tumor antigen uptake and presentation by dendritic cells to activate tumor-reactive T cells.2 A new study by Wang et al.adds another dimension to this paradigm by demonstrating that chemotherapy pretreatment of cancer cells can directly activate virtual memory(VM)CD8^(+)T cells to mediate tumor cytotoxicity in an antigen-independent manner.
