Natural herbs demonstrate significant therapeutic potential in managing chronic and complex diseases;however,their clinical application faces limitations due to low bioavailability,instability,toxicity,and herb-drug i...Natural herbs demonstrate significant therapeutic potential in managing chronic and complex diseases;however,their clinical application faces limitations due to low bioavailability,instability,toxicity,and herb-drug interactions.Furthermore,insufficient standardized evidence and global acceptance impede their widespread adoption.Liposomes,nanocarriers consisting of a phospholipid bilayer enclosing an aqueous core,present a promising approach for enhancing the pharmacokinetics and therapeutic efficacy of herbal compounds.These adaptable systems can encapsulate both hydrophilic and hydrophobic agents,enabling targeted drug delivery and enhanced stability.Moreover,liposomes can be modified to carry diagnostic and imaging agents,enabling precise disease detection and monitoring.While liposomes offer potential as an innovative delivery technology for herbal remedies,their application in Traditional Chinese Medicine(TCM)remains relatively unexplored.TCM,with its holistic,energy-based approach to health and organ function,presents distinct challenges regarding formulation and delivery.This review examines the therapeutic potential of herbal medicines,emphasizing how liposomes address delivery challenges within the TCM framework.It also investigates the integration of TCM with Western medical practices,demonstrating how liposomal systems may bridge these approaches.The review analyzes key formulation techniques for TCM-loaded liposomes,particularly the microfluidic method,which demonstrates superior control over particle size and encapsulation efficiency compared to conventional methods.The analysis addresses barriers to integrating liposomal delivery systems with TCM,including physicochemical properties,scalability issues,and regulatory challenges.Finally,this review provides strategic recommendations for overcoming these obstacles and identifies future research directions to maximize the potential of liposomal technology in enhancing TCM therapies.展开更多
Intracellular pH plays a significant role in various biological processes, including cell proliferation,apoptosis, metabolism, enzyme activity and homeostasis. In this work, a novel design strategy for the preparation...Intracellular pH plays a significant role in various biological processes, including cell proliferation,apoptosis, metabolism, enzyme activity and homeostasis. In this work, a novel design strategy for the preparation of pH responsive carbon dots(CDs-pH) for ratiometric intracellular imaging was reported. By using SciFinder database, fluorescent CDs-pH with the required p Kavalue of 6.84 were rationally designed, which is vital important for precise sensing of intracellular pH. As a result, the synthesized CDspH demonstrated robust ability to test pH fluctuations within the physiological range of 5.4-7.4. The CDspH was further utilized for fluorescent ratiometric imaging of pH in living HeLa cells, effectively avoided the influence of autofluorescence from native cellular species. Moreover, real-time monitoring of intracellular pH fluctuation under heat shock was successfully realized. This SciFinder-guided design strategy is simple and flexible, which has a great potential to be used for the development of other types of CDs for various applications.展开更多
Access to fresh water,its availability,and its quality are a global challenge to humanity,largely due to human activities in the environment.Thus,global water security has been jeopardized,requiring urgent remediation...Access to fresh water,its availability,and its quality are a global challenge to humanity,largely due to human activities in the environment.Thus,global water security has been jeopardized,requiring urgent remediation to safeguard our very existence.Hence,a novel and facilely engineered zirconium and polyethylenimine adsorbent based on tiger nut residue (TNR) was prepared,and its adsorptive capabilities towards a model dyestuff and nutrient were invested through a batch adsorption method.The developed adsorbent,zirconium-polyethylenimine-engineered tiger nut residue (TNR@PEI–Zr) was characterised by scanning electron microscopy,Fourier-transform infrared spectroscopy,X-ray diffraction analysis,and X-ray photoelectron spectroscopy to understand its morphology and surface chemistry and predict its adsorption mechanism.TNR@PEI–Zr had a p H point of zero charge (pH_(zpc)) of 6.7.The introduction of salts inhibited the removal efficiency of Alizarin red (AR) and phosphate (PO_(4)^(3–)) in the order of HCO_(3)^(-)>SO_(4)^(2–)>Cl^(-).Increasing temperatures (293–313 K) favoured the adsorption process at pH 3.The Langmuir model suited the adsorption processes of both AR and PO_(4)^(3–),implying homogenous and monolayer removal of pollutants with a maximal capacity of 537.8 mg·g^(-1)and 100.5 mg·g^(-1)at a dose of 0.01 g,respectively.The rate-determining steps of AR and PO_(4)^(3–)followed a pseudo-secondorder kinetic model and were thermodynamically spontaneous with an increase in randomness at the solid-solution interface.The adsorbent’s recyclability was notable and outperformed most adsorbents in terms of removal efficiency.TNR@PEI–Zr was found to be stable,and its use in practical wastewater decontamination was effective,ecologically acceptable and free of secondary pollution problems.展开更多
The adverse effects of eutrophication have prompted the use of various remediation techniques for phosphate(PO_(4)^(3-))removal owing to it being the major causative agent.Herein,the influence of different solvents an...The adverse effects of eutrophication have prompted the use of various remediation techniques for phosphate(PO_(4)^(3-))removal owing to it being the major causative agent.Herein,the influence of different solvents and ratios of 2-aminoterepthalicacid on the efficiency of magnetic biomass metal-organic framework composites based on the in situ growth of NH_(2)-MIL-101(Fe)onto magnetized peanut husks towards PO_(4)^(3-)removal was assessed via the adsorption technique.The magnetic biocomposite labelled as MPN@NH2-MIL-101(Fe)exhibited the best efficiency owing to its mesoporous structures and presence of abundant oxygen and nitrogen possessing functional groups.Adsorption results confirmed MPN@NH2-MIL-101(Fe)to have a high adsorption capacity of(14.0±0.3)mg·L^(-1)at a PO43-concentration of 20 mg·L^(-1)with an associated high stability within pH 2-10.The adsorption kinetics for the process was well described by both Elovich and pseudo-second-order kinetic models and was mediated by both internal diffusion and liquid film diffusion.The Temkin and Freundlich models fitted the equilibrium data well signifying occurrence of both physical and chemical adsorption on a heterogeneous surface.It is concluded that MPN@NH2-MIL-101(Fe)is a promising adsorbent for the effective removal of phosphate from a water body.展开更多
基金the Project of Hunan ScienceTechnology(Nos.2020JJ9011、2020JJ9020、2021JJ80078).
文摘Natural herbs demonstrate significant therapeutic potential in managing chronic and complex diseases;however,their clinical application faces limitations due to low bioavailability,instability,toxicity,and herb-drug interactions.Furthermore,insufficient standardized evidence and global acceptance impede their widespread adoption.Liposomes,nanocarriers consisting of a phospholipid bilayer enclosing an aqueous core,present a promising approach for enhancing the pharmacokinetics and therapeutic efficacy of herbal compounds.These adaptable systems can encapsulate both hydrophilic and hydrophobic agents,enabling targeted drug delivery and enhanced stability.Moreover,liposomes can be modified to carry diagnostic and imaging agents,enabling precise disease detection and monitoring.While liposomes offer potential as an innovative delivery technology for herbal remedies,their application in Traditional Chinese Medicine(TCM)remains relatively unexplored.TCM,with its holistic,energy-based approach to health and organ function,presents distinct challenges regarding formulation and delivery.This review examines the therapeutic potential of herbal medicines,emphasizing how liposomes address delivery challenges within the TCM framework.It also investigates the integration of TCM with Western medical practices,demonstrating how liposomal systems may bridge these approaches.The review analyzes key formulation techniques for TCM-loaded liposomes,particularly the microfluidic method,which demonstrates superior control over particle size and encapsulation efficiency compared to conventional methods.The analysis addresses barriers to integrating liposomal delivery systems with TCM,including physicochemical properties,scalability issues,and regulatory challenges.Finally,this review provides strategic recommendations for overcoming these obstacles and identifies future research directions to maximize the potential of liposomal technology in enhancing TCM therapies.
基金financial support from the National Natural Science Foundation of China (No. 21205108)the Foundation for University Key Teacher by Henan Province (No. 2017GGJS007)+1 种基金China Postdoctoral Science Foundation (Nos. 2017M620302, 2018T110736)the Key Scientific Research Project in Universities of Henan Province (No. 19A150048)
文摘Intracellular pH plays a significant role in various biological processes, including cell proliferation,apoptosis, metabolism, enzyme activity and homeostasis. In this work, a novel design strategy for the preparation of pH responsive carbon dots(CDs-pH) for ratiometric intracellular imaging was reported. By using SciFinder database, fluorescent CDs-pH with the required p Kavalue of 6.84 were rationally designed, which is vital important for precise sensing of intracellular pH. As a result, the synthesized CDspH demonstrated robust ability to test pH fluctuations within the physiological range of 5.4-7.4. The CDspH was further utilized for fluorescent ratiometric imaging of pH in living HeLa cells, effectively avoided the influence of autofluorescence from native cellular species. Moreover, real-time monitoring of intracellular pH fluctuation under heat shock was successfully realized. This SciFinder-guided design strategy is simple and flexible, which has a great potential to be used for the development of other types of CDs for various applications.
文摘Access to fresh water,its availability,and its quality are a global challenge to humanity,largely due to human activities in the environment.Thus,global water security has been jeopardized,requiring urgent remediation to safeguard our very existence.Hence,a novel and facilely engineered zirconium and polyethylenimine adsorbent based on tiger nut residue (TNR) was prepared,and its adsorptive capabilities towards a model dyestuff and nutrient were invested through a batch adsorption method.The developed adsorbent,zirconium-polyethylenimine-engineered tiger nut residue (TNR@PEI–Zr) was characterised by scanning electron microscopy,Fourier-transform infrared spectroscopy,X-ray diffraction analysis,and X-ray photoelectron spectroscopy to understand its morphology and surface chemistry and predict its adsorption mechanism.TNR@PEI–Zr had a p H point of zero charge (pH_(zpc)) of 6.7.The introduction of salts inhibited the removal efficiency of Alizarin red (AR) and phosphate (PO_(4)^(3–)) in the order of HCO_(3)^(-)>SO_(4)^(2–)>Cl^(-).Increasing temperatures (293–313 K) favoured the adsorption process at pH 3.The Langmuir model suited the adsorption processes of both AR and PO_(4)^(3–),implying homogenous and monolayer removal of pollutants with a maximal capacity of 537.8 mg·g^(-1)and 100.5 mg·g^(-1)at a dose of 0.01 g,respectively.The rate-determining steps of AR and PO_(4)^(3–)followed a pseudo-secondorder kinetic model and were thermodynamically spontaneous with an increase in randomness at the solid-solution interface.The adsorbent’s recyclability was notable and outperformed most adsorbents in terms of removal efficiency.TNR@PEI–Zr was found to be stable,and its use in practical wastewater decontamination was effective,ecologically acceptable and free of secondary pollution problems.
基金supported by the National Key Research and Development Program of China (2018YFD0401402–04)Zhongyuan Scholars Foundation (202101510005).
文摘The adverse effects of eutrophication have prompted the use of various remediation techniques for phosphate(PO_(4)^(3-))removal owing to it being the major causative agent.Herein,the influence of different solvents and ratios of 2-aminoterepthalicacid on the efficiency of magnetic biomass metal-organic framework composites based on the in situ growth of NH_(2)-MIL-101(Fe)onto magnetized peanut husks towards PO_(4)^(3-)removal was assessed via the adsorption technique.The magnetic biocomposite labelled as MPN@NH2-MIL-101(Fe)exhibited the best efficiency owing to its mesoporous structures and presence of abundant oxygen and nitrogen possessing functional groups.Adsorption results confirmed MPN@NH2-MIL-101(Fe)to have a high adsorption capacity of(14.0±0.3)mg·L^(-1)at a PO43-concentration of 20 mg·L^(-1)with an associated high stability within pH 2-10.The adsorption kinetics for the process was well described by both Elovich and pseudo-second-order kinetic models and was mediated by both internal diffusion and liquid film diffusion.The Temkin and Freundlich models fitted the equilibrium data well signifying occurrence of both physical and chemical adsorption on a heterogeneous surface.It is concluded that MPN@NH2-MIL-101(Fe)is a promising adsorbent for the effective removal of phosphate from a water body.
