Ficus religiosa L.(F.religiosa)or sacred fig is a large perennial tree belonging to the family Moraceae or mulberry family.Though the tree has pan-tropical distribution but originally it is indigenous to the Indian su...Ficus religiosa L.(F.religiosa)or sacred fig is a large perennial tree belonging to the family Moraceae or mulberry family.Though the tree has pan-tropical distribution but originally it is indigenous to the Indian subcontinent and Indochina region.Popularly the tree is named"Pepal or bodhi tree".Traditionally,it is practiced for the treatment of asthma,nose bleeding,heart disorders,diabetes,wound healing,ear problems,constipation,hyperlipidemia,gonorrhea,ulcers and infectious disorders.Chemical analysis demonstrated the presence of numerous bioactives including tannins,phenols,saponins,sugars,alkaloids,methionine,terpenoids,flavonoids,glycosides,proteins,separated amino acids,essential and volatile oils and steroids etc.,which are probably responsible for its diverse pharmacological actions.The present work is an attempt to compile up-to-date comprehensive information on F.religiosa that covers its taxonomy,ethnomedicinal importance,phytochemistry,pharmacological attributes and clinical trials.Keeping in mind the various health attributes of F.religiosa,future research can be aimed at in-depth elucidation of the structure-function relationship and multifactorial signalings pathways.展开更多
Herbal medicine is safe and effective in treating various diseases.Traditional herbal medicine plays a tremendous role in treatment of various diseases and accompanying complications,hence herbal medicine requires rem...Herbal medicine is safe and effective in treating various diseases.Traditional herbal medicine plays a tremendous role in treatment of various diseases and accompanying complications,hence herbal medicine requires remarkable attention in further research for the development of numerous active formulations for treatment of health troubles.The plant needs special consideration for development and research of unidentified compound and characterization of novel active molecules that overcome multiple pathological abnormalities.The genus Manilkara contains 135 plants around the world.This overview discusses all the virtues of most important and commonly used plant Manilkara zapota(L.)P.Royen(M.zapota),also known as Sapodilla.M.zapota has various traditional beneficial effects in treatment of various diseases and disorders dating back to prehistoric times and used in ancient traditional system of herbal medicine.展开更多
Discovering potent drug candidates requires new antimalarial targets.For this reason,antimalarial drug researchers focus on developing new drug candidates on promising targets.In the identification of these targets,a ...Discovering potent drug candidates requires new antimalarial targets.For this reason,antimalarial drug researchers focus on developing new drug candidates on promising targets.In the identification of these targets,a basic understanding of the metabolism and biochemical processes of malaria parasites such as Plasmodium falciparum can prove invaluable.However,malarial resistant parasites are becoming more and more significant issues as antimalarial medications progress.Antimalarial drugs are becoming increasingly resistant,thus the search for new molecules is very important task.Artemisinin based combination therapies are becoming more popular for treating malaria.This will ultimately lead to the selection of resistance due to their extensive and indiscriminate deployment.Alternative artemisinin-based combination therapies are therefore required.There is an interest in finding suitable antimalarial compounds based on their potential effectiveness against malaria.The potential activity of 1,3,4 oxadiazole analogues against malarial infections is a major draw of the search for suitable antimalarial compounds.This review identifies existing antimalarial drugs that have own therapeutic effects and evaluating their feasibility for developing novel synthetic antimalarial derivatives.展开更多
Albizia lebbeck Benth,commonly referred to as Indian Siris,is a therapeutically potential plant drug and a financially significant plant with mechanical,therapeutic uses.The leaves of the plant are a rich source of pr...Albizia lebbeck Benth,commonly referred to as Indian Siris,is a therapeutically potential plant drug and a financially significant plant with mechanical,therapeutic uses.The leaves of the plant are a rich source of protein and are said to have significant efficacy against cancer cells.The plant contains a variety of secondary metabolites such as alkaloids,flavonoids,saponins,anthraquinones,phenols and essential oils.Pharmacological reports of the extract of A.lebbek show the diverse pharmacological effects such as anti-inflammatory,antibacterial,anti-fertility,antifungal,anthelmintic,antiulcer etc.The present review paper contains the literature on the scientific reports on the pharmacological and phytochemical importance of A.lebbek,which could be a good source of information for researchers,scientists and industry for future reference.展开更多
Background:Alzheimer’s disease affects millions of people worldwide,and one of its major characteristics is the accumulation of extracellular Aβpeptides in the human brain,leading to neuronal death and resulting in ...Background:Alzheimer’s disease affects millions of people worldwide,and one of its major characteristics is the accumulation of extracellular Aβpeptides in the human brain,leading to neuronal death and resulting in memory deficits,disorientation,and inappropriate behaviour.Objective and Methodology:This review study aims to develop new molecular targets for major depression-associated cognitive dysfunction and determine the mechanisms of action of 1,3,4-oxadiazole-based drug candidates.It encourages scientists to develop and synthesize drugs with low side effects to treat Alzheimer’s disease.Furthermore,the drug has shown significant improvement in memory function among dementia patients,which is due to the increased production of acetylcholine in the brain.These derivatives show a high affinity to amyloid plaques,which are thought to cause cognitive damage in patients with Alzheimer’s disease.This review study emphasizes newly developed inhibitors of amyloid deposition using the enzymeα-secretase,which cleaves amyloid precursor protein into smaller fragments that are toxic to neurons.1,3,4-Oxadiazole compounds have demonstrated no significant toxicity to the central nervous system.The antioxidant properties of 1,3,4-oxadiazoles can reduce free radicals,which play an active role in cell damage and disease.Conclusion:This review aims to provide readers with an overview of the current state of knowledge about oxadiazole-related drugs,emphasizing their biological importance.Key aspects related to the discovery and development of these drug candidates are discussed in detail,including information on their structure,biological activity,chemistry,and pharmacological properties.In addition,different derivatives discovered for Alzheimer’s disease to enhance the therapeutic efficiency of oxadiazole drugs have been comprehensively discussed in this review.展开更多
Currently,cancer is the most rapidly growing life-threatening disease after cardiovascular in the world,posing a major threat to human life.Telomerase promotes tumorigenesis and development in most cancers and dyskeri...Currently,cancer is the most rapidly growing life-threatening disease after cardiovascular in the world,posing a major threat to human life.Telomerase promotes tumorigenesis and development in most cancers and dyskerin plays a crucial role in telomere maintenance.Cancer molecules are being developed continuously as a result of continuous research.A series of novel anticancer agents have been developed using telomerase inhibitors with improved specificity and pharmacokinetics.As medicinal chemistry advances,heterocyclic-based drugs find increasing applications,including anticancer agents.These properties have led to the development of five-membered aromatic rings of oxadiazoles.In order to enhance their anticancer activity,oxadiazole scaffolds can be modified.In this review,we discuss the functions and mechanism of action of the telomerase enzyme.The paper also summarizes the interaction between 1,3,4-oxadiazole inhibitors and telomerase enzymes.展开更多
文摘Ficus religiosa L.(F.religiosa)or sacred fig is a large perennial tree belonging to the family Moraceae or mulberry family.Though the tree has pan-tropical distribution but originally it is indigenous to the Indian subcontinent and Indochina region.Popularly the tree is named"Pepal or bodhi tree".Traditionally,it is practiced for the treatment of asthma,nose bleeding,heart disorders,diabetes,wound healing,ear problems,constipation,hyperlipidemia,gonorrhea,ulcers and infectious disorders.Chemical analysis demonstrated the presence of numerous bioactives including tannins,phenols,saponins,sugars,alkaloids,methionine,terpenoids,flavonoids,glycosides,proteins,separated amino acids,essential and volatile oils and steroids etc.,which are probably responsible for its diverse pharmacological actions.The present work is an attempt to compile up-to-date comprehensive information on F.religiosa that covers its taxonomy,ethnomedicinal importance,phytochemistry,pharmacological attributes and clinical trials.Keeping in mind the various health attributes of F.religiosa,future research can be aimed at in-depth elucidation of the structure-function relationship and multifactorial signalings pathways.
文摘Herbal medicine is safe and effective in treating various diseases.Traditional herbal medicine plays a tremendous role in treatment of various diseases and accompanying complications,hence herbal medicine requires remarkable attention in further research for the development of numerous active formulations for treatment of health troubles.The plant needs special consideration for development and research of unidentified compound and characterization of novel active molecules that overcome multiple pathological abnormalities.The genus Manilkara contains 135 plants around the world.This overview discusses all the virtues of most important and commonly used plant Manilkara zapota(L.)P.Royen(M.zapota),also known as Sapodilla.M.zapota has various traditional beneficial effects in treatment of various diseases and disorders dating back to prehistoric times and used in ancient traditional system of herbal medicine.
文摘Discovering potent drug candidates requires new antimalarial targets.For this reason,antimalarial drug researchers focus on developing new drug candidates on promising targets.In the identification of these targets,a basic understanding of the metabolism and biochemical processes of malaria parasites such as Plasmodium falciparum can prove invaluable.However,malarial resistant parasites are becoming more and more significant issues as antimalarial medications progress.Antimalarial drugs are becoming increasingly resistant,thus the search for new molecules is very important task.Artemisinin based combination therapies are becoming more popular for treating malaria.This will ultimately lead to the selection of resistance due to their extensive and indiscriminate deployment.Alternative artemisinin-based combination therapies are therefore required.There is an interest in finding suitable antimalarial compounds based on their potential effectiveness against malaria.The potential activity of 1,3,4 oxadiazole analogues against malarial infections is a major draw of the search for suitable antimalarial compounds.This review identifies existing antimalarial drugs that have own therapeutic effects and evaluating their feasibility for developing novel synthetic antimalarial derivatives.
文摘Albizia lebbeck Benth,commonly referred to as Indian Siris,is a therapeutically potential plant drug and a financially significant plant with mechanical,therapeutic uses.The leaves of the plant are a rich source of protein and are said to have significant efficacy against cancer cells.The plant contains a variety of secondary metabolites such as alkaloids,flavonoids,saponins,anthraquinones,phenols and essential oils.Pharmacological reports of the extract of A.lebbek show the diverse pharmacological effects such as anti-inflammatory,antibacterial,anti-fertility,antifungal,anthelmintic,antiulcer etc.The present review paper contains the literature on the scientific reports on the pharmacological and phytochemical importance of A.lebbek,which could be a good source of information for researchers,scientists and industry for future reference.
文摘Background:Alzheimer’s disease affects millions of people worldwide,and one of its major characteristics is the accumulation of extracellular Aβpeptides in the human brain,leading to neuronal death and resulting in memory deficits,disorientation,and inappropriate behaviour.Objective and Methodology:This review study aims to develop new molecular targets for major depression-associated cognitive dysfunction and determine the mechanisms of action of 1,3,4-oxadiazole-based drug candidates.It encourages scientists to develop and synthesize drugs with low side effects to treat Alzheimer’s disease.Furthermore,the drug has shown significant improvement in memory function among dementia patients,which is due to the increased production of acetylcholine in the brain.These derivatives show a high affinity to amyloid plaques,which are thought to cause cognitive damage in patients with Alzheimer’s disease.This review study emphasizes newly developed inhibitors of amyloid deposition using the enzymeα-secretase,which cleaves amyloid precursor protein into smaller fragments that are toxic to neurons.1,3,4-Oxadiazole compounds have demonstrated no significant toxicity to the central nervous system.The antioxidant properties of 1,3,4-oxadiazoles can reduce free radicals,which play an active role in cell damage and disease.Conclusion:This review aims to provide readers with an overview of the current state of knowledge about oxadiazole-related drugs,emphasizing their biological importance.Key aspects related to the discovery and development of these drug candidates are discussed in detail,including information on their structure,biological activity,chemistry,and pharmacological properties.In addition,different derivatives discovered for Alzheimer’s disease to enhance the therapeutic efficiency of oxadiazole drugs have been comprehensively discussed in this review.
文摘Currently,cancer is the most rapidly growing life-threatening disease after cardiovascular in the world,posing a major threat to human life.Telomerase promotes tumorigenesis and development in most cancers and dyskerin plays a crucial role in telomere maintenance.Cancer molecules are being developed continuously as a result of continuous research.A series of novel anticancer agents have been developed using telomerase inhibitors with improved specificity and pharmacokinetics.As medicinal chemistry advances,heterocyclic-based drugs find increasing applications,including anticancer agents.These properties have led to the development of five-membered aromatic rings of oxadiazoles.In order to enhance their anticancer activity,oxadiazole scaffolds can be modified.In this review,we discuss the functions and mechanism of action of the telomerase enzyme.The paper also summarizes the interaction between 1,3,4-oxadiazole inhibitors and telomerase enzymes.
