OBJECTIVE:To investigate the effects of Jiawei Huangqi Guizhi decoction(加味黄芪桂枝汤)on chronic atrophic gastritis(CAG)in rats and its modulation of the phosphatidylinositol 3-kinase/protein kinase B/mechanistic tar...OBJECTIVE:To investigate the effects of Jiawei Huangqi Guizhi decoction(加味黄芪桂枝汤)on chronic atrophic gastritis(CAG)in rats and its modulation of the phosphatidylinositol 3-kinase/protein kinase B/mechanistic target of rapamycin complex 2(PI3K/Akt/m TORC2)signaling pathway.METHODS:CAG was induced in rats and treated with high-,medium-,or low-dose Jiawei Huangqi Guizhi decoction.Gastric histopathology was observed by hematoxylin and eosin staining.Serum levels of gastrin,PI3K,Akt,and m TORC2 were detected by enzyme-linked immunosorbent assay.Gene and protein expression levels were analyzed by reverse transcription polymerase chain reaction and western blot.RESULTS:The decoction alleviated gastric mucosal injury,reduced inflammation,and restored epithelial structure.It regulated PI3K,Akt,and m TORC2 expression at both m RNA and protein levels.CONCLUSION:Jiawei Huangqi Guizhi decoction may prevent CAG progression by improving gastric tissue and modulating the PI3K/Akt/m TORC2 signaling pathway.展开更多
Using emergy analysis method,I conduct quantitative analysis of social,economic and natural systems in Sichuan's Baisha River valley during the period 2002-2006,through the establishment of indicators.I compare th...Using emergy analysis method,I conduct quantitative analysis of social,economic and natural systems in Sichuan's Baisha River valley during the period 2002-2006,through the establishment of indicators.I compare the emergy of Baisha River valley,with that of Xinjiang's Manas River valley and Sichuan Province,and evaluate the sustainable development conditions in Baisha River valley,in order to provide corresponding reference for the development and utilization of Baisha River valley in the future.The results show that from the perspective of emergy input of economic system,Baisha River valley is a typical ecological and economic zone with rich resources to be developed;in terms of the development of natural conditions and utilization of ecological resources,the resource utilization intensity of Baisha River valley is weak and the environmental loading ratio there is low,thus the level of emergy yield needs to be improved;the system of Baisha River valley has enormous capacity for sustainable development and good potential for development.展开更多
基金Supported by Guangzhou Science and Technology Bureau Research Fund:the Mechanism of Action of Huangqi Guizhi Decoction on Precancerous Lesions in Cag Rats was Studied based on the Phosphatidylinositol 3-Kinase-Protein Kinase B-Mechanistic Target of Rapamycin Complex 2 Pathway(No.202102080643)Guangzhou Traditional Chinese Medicine and Integrative Medicine Research Project:Observation on the Therapeutic Effect of Wenyang Jianpi Ointment on Chronic Atrophic Gastritis of Spleen and Stomach Weakness Type and Study on its Regulatory Effect on Transforming Growth Factor Beta 3(No.20222A010079)Panyu District Science and Technology Project:the Mechanism by which the Modified Huangqi Guizhi Decoction Regulates the Transforming Growth Factor-β3 Signaling Pathway to Improve Precancerous Lesions in Rats with Chronic Atrophic Gastritis(No.2020-Z04-025)。
文摘OBJECTIVE:To investigate the effects of Jiawei Huangqi Guizhi decoction(加味黄芪桂枝汤)on chronic atrophic gastritis(CAG)in rats and its modulation of the phosphatidylinositol 3-kinase/protein kinase B/mechanistic target of rapamycin complex 2(PI3K/Akt/m TORC2)signaling pathway.METHODS:CAG was induced in rats and treated with high-,medium-,or low-dose Jiawei Huangqi Guizhi decoction.Gastric histopathology was observed by hematoxylin and eosin staining.Serum levels of gastrin,PI3K,Akt,and m TORC2 were detected by enzyme-linked immunosorbent assay.Gene and protein expression levels were analyzed by reverse transcription polymerase chain reaction and western blot.RESULTS:The decoction alleviated gastric mucosal injury,reduced inflammation,and restored epithelial structure.It regulated PI3K,Akt,and m TORC2 expression at both m RNA and protein levels.CONCLUSION:Jiawei Huangqi Guizhi decoction may prevent CAG progression by improving gastric tissue and modulating the PI3K/Akt/m TORC2 signaling pathway.
文摘Using emergy analysis method,I conduct quantitative analysis of social,economic and natural systems in Sichuan's Baisha River valley during the period 2002-2006,through the establishment of indicators.I compare the emergy of Baisha River valley,with that of Xinjiang's Manas River valley and Sichuan Province,and evaluate the sustainable development conditions in Baisha River valley,in order to provide corresponding reference for the development and utilization of Baisha River valley in the future.The results show that from the perspective of emergy input of economic system,Baisha River valley is a typical ecological and economic zone with rich resources to be developed;in terms of the development of natural conditions and utilization of ecological resources,the resource utilization intensity of Baisha River valley is weak and the environmental loading ratio there is low,thus the level of emergy yield needs to be improved;the system of Baisha River valley has enormous capacity for sustainable development and good potential for development.
