Hyponatremia is the most common electrolyte disorder in hospitalized patients. The incidence rate is about 15% to 22%. It is also the most common electrolyte disorder in cancer, like lung cancer, digestive tract cance...Hyponatremia is the most common electrolyte disorder in hospitalized patients. The incidence rate is about 15% to 22%. It is also the most common electrolyte disorder in cancer, like lung cancer, digestive tract cancer and central nervous system tumors. According to statistics, 1% - 2% of malignant tumor patients will have SIADH syndrome and most of them are small cell lung cancer patients.展开更多
目的探究中医药干预糖尿病肾病(DKD)氧化应激反应研究现状、热点及趋势,为相关研究提供参考。方法检索2005年1月1日-2024年12月31日中国知识资源总库(CNKI)、中文科技期刊数据库(VIP)、中国学术期刊数据库(万方数据)、Web of Science数...目的探究中医药干预糖尿病肾病(DKD)氧化应激反应研究现状、热点及趋势,为相关研究提供参考。方法检索2005年1月1日-2024年12月31日中国知识资源总库(CNKI)、中文科技期刊数据库(VIP)、中国学术期刊数据库(万方数据)、Web of Science数据库收录的中医药干预DKD氧化应激反应研究文献,采用NoteExpress4.0.0.9855软件清洗数据,采用Excel2016软件分析发文趋势,采用CiteSpace6.1.R6软件对作者、机构、关键词进行共现分析及关键词聚类、时间线、突现分析。结果共纳入中文文献766篇、英文文献185篇,年发文量总体呈上升趋势。中文发文较多作者为朱海慧、陈志强、刘伟敬和郭登洲,英文发文较多作者为Cao,Aili(曹爱丽)、Zhang,Hui(张辉)、Lv,Shuquan(吕树泉),团队间合作较少;中文发文最多的机构为北京中医药大学,英文发文最多的为Shanghai University of Traditional Chinese Medicine(上海中医药大学)。根据关键词研究发现,该领域中英文研究热点主要集中于网络药理学、机制研究、肾损伤、临床研究、细胞调控。结论中医药干预DKD氧化应激反应发文量不断增加,发文机构地域性较明显,跨区域合作不足。中医药干预DKD氧化应激反应靶点与机制研究和具体疗效作用研究为近年来研究热点,机制探索研究、高质量临床随机对照试验研究、动物实验成果转化、加强中药复方研发可能为今后研究的重要方向。展开更多
To estimate genetic variation in rhizome lotus （Nelumbo nucifera Gaertn. ssp. nucifera） germplasms in China, a total of 94 rhizome lotus germplasms collected from 18 provinces in China were assessed. The RAPD （rand...To estimate genetic variation in rhizome lotus （Nelumbo nucifera Gaertn. ssp. nucifera） germplasms in China, a total of 94 rhizome lotus germplasms collected from 18 provinces in China were assessed. The RAPD （randomly amplified polymorphic DNA） marker was employed. The selected 17 random primers detected 139 polymorphic alleles out of a total 207 （67.15%）. Nei＇s gene diversity statistics and region differentiation parameters indicated that all germplasms had a relatively high level of genetic diversity with ne = 1.3202, h = 0.1937, I= 0.2982 and the gene flow among all regions was Nrn = 5.5742. The UPGMA dendrogram clustered all 94 germplasms into two clusters： One contained eight commercial cultivars and major landraces, and the other included the wild and some special landraces from five regions, and the PCA analysis exhibited the similar result. Those germplasms from southwestern and eastern China had higher genetic diversity than those from the southern, northern and central China. Predominant proportion of genetic variation （95.61%） was found significant within rather than among （4.39%） regions, as revealed by AMOVA analysis. The data analysis also revealed that the genetic diversity of rhizome lotus germplasms among different regions is positively related to their geographic distances, though it is ambiguous to find the trend from the UPGMA dendrogram and the PCA analysis. A relatively high genetic diversity and gene flow resided in the root lotus germplasms; about 96% of the variation was found within region; accessions from southwest and eastern China have higher genetic diversity than those from the southern, northern and central China.展开更多
Many wellbores are blocked by asphaltene deposits,which lead to production problems in the oilfield development process.In this paper,methods such as elemental analysis,and solvent extraction are adopted for the study...Many wellbores are blocked by asphaltene deposits,which lead to production problems in the oilfield development process.In this paper,methods such as elemental analysis,and solvent extraction are adopted for the study of wellbore blockages.The content of organic matter in blockages is higher than 96% and asphaltene is the main component of the organic matter with n-heptane asphaltene content of 38%.Based on the above analyses,an agent for asphaltene dispersion and removal（named as SDJ） was developed.The performance of the SDJ agent was evaluated,and it was found that the dissolution rate of asphaltene can reach 2.9 mg.mL-1.min-1 at 60 oC.SDJ agent（1wt%） was added to crude oil with a colloid instability index greater than 0.9 can effectively inhibit asphaltene deposition in the wellbore.By the viscosity method,the dissolution amount of SDJ agent was calculated,and it was found that when the viscosity of the system is around 2,000 mPa.s（the common viscosity of crude oil）,the amount of SDJ agent added to the blockage was at least 96 g per 100 g blockages.Therefore,SDJ agent has promising application for dispersion and removal of asphaltene deposition in high-asphaltene wells.展开更多
文摘Hyponatremia is the most common electrolyte disorder in hospitalized patients. The incidence rate is about 15% to 22%. It is also the most common electrolyte disorder in cancer, like lung cancer, digestive tract cancer and central nervous system tumors. According to statistics, 1% - 2% of malignant tumor patients will have SIADH syndrome and most of them are small cell lung cancer patients.
文摘目的探究中医药干预糖尿病肾病(DKD)氧化应激反应研究现状、热点及趋势,为相关研究提供参考。方法检索2005年1月1日-2024年12月31日中国知识资源总库(CNKI)、中文科技期刊数据库(VIP)、中国学术期刊数据库(万方数据)、Web of Science数据库收录的中医药干预DKD氧化应激反应研究文献,采用NoteExpress4.0.0.9855软件清洗数据,采用Excel2016软件分析发文趋势,采用CiteSpace6.1.R6软件对作者、机构、关键词进行共现分析及关键词聚类、时间线、突现分析。结果共纳入中文文献766篇、英文文献185篇,年发文量总体呈上升趋势。中文发文较多作者为朱海慧、陈志强、刘伟敬和郭登洲,英文发文较多作者为Cao,Aili(曹爱丽)、Zhang,Hui(张辉)、Lv,Shuquan(吕树泉),团队间合作较少;中文发文最多的机构为北京中医药大学,英文发文最多的为Shanghai University of Traditional Chinese Medicine(上海中医药大学)。根据关键词研究发现,该领域中英文研究热点主要集中于网络药理学、机制研究、肾损伤、临床研究、细胞调控。结论中医药干预DKD氧化应激反应发文量不断增加,发文机构地域性较明显,跨区域合作不足。中医药干预DKD氧化应激反应靶点与机制研究和具体疗效作用研究为近年来研究热点,机制探索研究、高质量临床随机对照试验研究、动物实验成果转化、加强中药复方研发可能为今后研究的重要方向。
文摘To estimate genetic variation in rhizome lotus （Nelumbo nucifera Gaertn. ssp. nucifera） germplasms in China, a total of 94 rhizome lotus germplasms collected from 18 provinces in China were assessed. The RAPD （randomly amplified polymorphic DNA） marker was employed. The selected 17 random primers detected 139 polymorphic alleles out of a total 207 （67.15%）. Nei＇s gene diversity statistics and region differentiation parameters indicated that all germplasms had a relatively high level of genetic diversity with ne = 1.3202, h = 0.1937, I= 0.2982 and the gene flow among all regions was Nrn = 5.5742. The UPGMA dendrogram clustered all 94 germplasms into two clusters： One contained eight commercial cultivars and major landraces, and the other included the wild and some special landraces from five regions, and the PCA analysis exhibited the similar result. Those germplasms from southwestern and eastern China had higher genetic diversity than those from the southern, northern and central China. Predominant proportion of genetic variation （95.61%） was found significant within rather than among （4.39%） regions, as revealed by AMOVA analysis. The data analysis also revealed that the genetic diversity of rhizome lotus germplasms among different regions is positively related to their geographic distances, though it is ambiguous to find the trend from the UPGMA dendrogram and the PCA analysis. A relatively high genetic diversity and gene flow resided in the root lotus germplasms; about 96% of the variation was found within region; accessions from southwest and eastern China have higher genetic diversity than those from the southern, northern and central China.
基金the National High Technology Research and Development Program of China (No.SS2013AA060801)National Natural Science Foundation of China (No.51274210)12th National Science and Technology Major Project of Ministry of Science and Technology of China (No. 20112X05049-003-001-002)for financial support
文摘Many wellbores are blocked by asphaltene deposits,which lead to production problems in the oilfield development process.In this paper,methods such as elemental analysis,and solvent extraction are adopted for the study of wellbore blockages.The content of organic matter in blockages is higher than 96% and asphaltene is the main component of the organic matter with n-heptane asphaltene content of 38%.Based on the above analyses,an agent for asphaltene dispersion and removal（named as SDJ） was developed.The performance of the SDJ agent was evaluated,and it was found that the dissolution rate of asphaltene can reach 2.9 mg.mL-1.min-1 at 60 oC.SDJ agent（1wt%） was added to crude oil with a colloid instability index greater than 0.9 can effectively inhibit asphaltene deposition in the wellbore.By the viscosity method,the dissolution amount of SDJ agent was calculated,and it was found that when the viscosity of the system is around 2,000 mPa.s（the common viscosity of crude oil）,the amount of SDJ agent added to the blockage was at least 96 g per 100 g blockages.Therefore,SDJ agent has promising application for dispersion and removal of asphaltene deposition in high-asphaltene wells.
