Multi-dimensional arrays are referred to as tensors.Tensor-valued predictors are commonly encountered in modern biomedical applications,such as electroencephalogram(EEG),magnetic resonance imaging(MRI),functional MRI(...Multi-dimensional arrays are referred to as tensors.Tensor-valued predictors are commonly encountered in modern biomedical applications,such as electroencephalogram(EEG),magnetic resonance imaging(MRI),functional MRI(fMRI),diffusion-weighted MRI,and longitudinal health data.In survival analysis,it is both important and challenging to integrate clinically relevant information,such as gender,age,and disease state along with medical imaging tensor data or longitudinal health data to predict disease outcomes.Most existing higher-order sufficient dimension reduction regressions for matrix-or array-valued data focus solely on tensor data,often neglecting established clinical covariates that are readily available and known to have predictive value.Based on the idea of Folded-Minimum Average Variance Estimation(Folded-MAVE:Xue and Yin,2014),the authors propose a new method,Partial Dimension Folded-MAVE(PF-MAVE),to address regression mean functions with tensor-valued covariates while simultaneously incorporating clinical covariates,which are typically categorical variables.Theorems and simulation studies demonstrate the importance of incorporating these categorical clinical predictors.A survival analysis of a longitudinal study of primary biliary cirrhosis(PBC)data is included for illustration of the proposed method.展开更多
文摘Multi-dimensional arrays are referred to as tensors.Tensor-valued predictors are commonly encountered in modern biomedical applications,such as electroencephalogram(EEG),magnetic resonance imaging(MRI),functional MRI(fMRI),diffusion-weighted MRI,and longitudinal health data.In survival analysis,it is both important and challenging to integrate clinically relevant information,such as gender,age,and disease state along with medical imaging tensor data or longitudinal health data to predict disease outcomes.Most existing higher-order sufficient dimension reduction regressions for matrix-or array-valued data focus solely on tensor data,often neglecting established clinical covariates that are readily available and known to have predictive value.Based on the idea of Folded-Minimum Average Variance Estimation(Folded-MAVE:Xue and Yin,2014),the authors propose a new method,Partial Dimension Folded-MAVE(PF-MAVE),to address regression mean functions with tensor-valued covariates while simultaneously incorporating clinical covariates,which are typically categorical variables.Theorems and simulation studies demonstrate the importance of incorporating these categorical clinical predictors.A survival analysis of a longitudinal study of primary biliary cirrhosis(PBC)data is included for illustration of the proposed method.
