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Miniature optical fiber accelerometer based on an in-situ 3D microprinted ferrule-top Fabry–Pérot microinterferometer
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作者 Peng Wang Taige Li +4 位作者 Htein Lin Pengcheng Zhao Shangming Liu Hwa-Yaw Tam a.ping zhang 《Light: Advanced Manufacturing》 2025年第1期148-156,共9页
Accelerometers are crucial sensors that measure acceleration resulting from motion or vibration.Compared with their electromechanical counterparts,optical accelerometers are widely regarded as the most promising techn... Accelerometers are crucial sensors that measure acceleration resulting from motion or vibration.Compared with their electromechanical counterparts,optical accelerometers are widely regarded as the most promising technology for high-requirement applications.However,compact integration of various optical and mechanical components to create a miniature optomechanical microsystem for acceleration sensing remains a challenge.In this study,we present a miniature optical fiber accelerometer based on a 3D microprinted ferrule-top Fabry–Pérot(FP)microinterferometer.In-situ 3D microprinting technology was developed to directly print a sub-millimeter-scale 3D proof mass/thin-film reflector-integrated FP microinterferometer on the inherently light-coupled end face of a fiber optic ferrule.Experimental results demonstrate that the optical fiber accelerometer has a flat response over a bandwidth of 2 to 3 kHz and its noise equivalent acceleration is 62.45μg/Hz under 1-g acceleration at 2 kHz.This ultracompact optical fiber interferometric accelerometer offers several distinct advantages,including immunity to electromagnetic interference,remote-sensing capability,and high customizability,making it highly promising for a variety of stringent acceleration-monitoring applications. 展开更多
关键词 Optical fiber accelerometer Optomechanical sensor Fabry–Pérot interferometer 3D microprinting
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通过柔性微针阵列集成的叉指电极装置产生电刺激用于癌症免疫治疗 被引量:5
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作者 潘奕璇 张扬熙 +10 位作者 史雪莹 李冬冬 徐晓丹 肖冰 朴莹 相佳佳 邵世群 Frederic Chun-Yip Ho 申有青 张阿平 唐建斌 《Science Bulletin》 SCIE EI CAS CSCD 2023年第22期2779-2792,M0005,M0006,共16页
免疫疗法通过化学或生物制剂来激活免疫系统,改变了癌症治疗的传统方式.但大多数免疫类药物在肿瘤组织内的渗透性差,容易产生副作用而使疗效不尽人意.电刺激疗法是一种新颖的癌症疗法,其可以不利用化学、生物制剂产生抑癌效果,但存在操... 免疫疗法通过化学或生物制剂来激活免疫系统,改变了癌症治疗的传统方式.但大多数免疫类药物在肿瘤组织内的渗透性差,容易产生副作用而使疗效不尽人意.电刺激疗法是一种新颖的癌症疗法,其可以不利用化学、生物制剂产生抑癌效果,但存在操作复杂和难以制备微米级小型电刺激装置的问题.本文通过将光学3D微打印技术与化学镀工艺结合,成功制备了柔性微针阵列集成的叉指电极装置.其能够生成交变电场触发肿瘤细胞内线粒体的钙离子过载和细胞内活性氧的产生,导致损伤相关分子模式释放,从而激活免疫应答并引起肿瘤免疫原性细胞死亡.实验结果显示,本文的通电微针装置具有良好的生物安全性和全身抑瘤作用,抑制了原发肿瘤和远处肿瘤的生长以及黑色素瘤肺转移.因此,本文将电刺激与免疫疗法相结合,为无药物癌症治疗提供了新方向并为癌症治疗领域提供了创新思路. 展开更多
关键词 Electrical stimulation MICRONEEDLE Interdigital electrode MELANOMA Immunogenic cell death
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