3(R)-(t-Butyldiphenylsilyloxy)-1-penten-4-yne was prepared using D-xylose as the chiral template via an improved procedure for aldehyde-to-alkyne homologation in high yield.
In our effort to asymmetric synthesis of R-(+)-shikonin,a novel acetyl migration was found,and the mechanism of the migration was considered to be mediated by a 6 atom-ring intermediate.
基金the State Key Laboratory of Drug Research for the financial support.
文摘3(R)-(t-Butyldiphenylsilyloxy)-1-penten-4-yne was prepared using D-xylose as the chiral template via an improved procedure for aldehyde-to-alkyne homologation in high yield.
文摘In our effort to asymmetric synthesis of R-(+)-shikonin,a novel acetyl migration was found,and the mechanism of the migration was considered to be mediated by a 6 atom-ring intermediate.
