The new technology of direct decomposition of H_(2)S into high value-added H_(2) and S,as an alternative to the Claus process in industry,is an ideal route that can not only deal with toxic and abundant H_(2)S waste g...The new technology of direct decomposition of H_(2)S into high value-added H_(2) and S,as an alternative to the Claus process in industry,is an ideal route that can not only deal with toxic and abundant H_(2)S waste gas but also recover clean energy H_(2),which has significant socio-economic and ecological advantages.However,the highly effective decomposition of H_(2)S at low temperatures is still a great challenge,because of the stringent thermodynamic equilibrium constraints(only 20% even at high temperature of 1010℃).Conventional microwave catalysts exhibit unsatisfactory performance at low temperatures(below 600℃).Herein,Mo_(2)C@CeO_(2) catalysts with a core-shell structure were successfully developed for robust microwave catalytic decomposition of H_(2)S at low temperatures.Two carbon precursors,para-phenylenediamine(Mo_(2)C-p)and meta-phenylenediamine(Mo_(2)C-m),were employed to tailor Mo_(2)C configurations.Remarkably,the H_(2)S conversion of Mo_(2)C-p@CeO_(2) catalyst at a low temperature of 550℃ is as high as 92.1%,which is much higher than the H_(2)S equilibrium conversion under the conventional thermal conditions(2.6% at 550℃).To our knowledge,this represents the most active catalyst for microwave catalytic decomposition of H_(2)S at low temperature of 550℃.Notably,Mo_(2)C-p demonstrated superior intrinsic activity(84%)compared to Mo_(2)C-m(6.4%),with XPS analysis revealing that its enhanced performance stems from a higher concentration of Mo_(2+)active sites.This work presents a substitute approach for the efficient utilization of H_(2)S waste gas and opens up a novel avenue for the rational design of microwave catalysts for microwave catalytic reaction at low-temperature.展开更多
This paper establishes a experiential model about stock price of Chinese listed company by using Feltham Ohlson stock option theory and model, and examines how listed company accounting statement data of China stock m...This paper establishes a experiential model about stock price of Chinese listed company by using Feltham Ohlson stock option theory and model, and examines how listed company accounting statement data of China stock market from 1993 to 2001 affect listed company stock price. It also studies the influence of company growth, capital structure,company core assets profitability and the scale of floating stock on stock price. The result demonstrates that accounting earnings, net assets, the growth of company profitability, company core assets profitability,company scale and the scale of floating stock not only relate with stock price, but also can explain stock price. But capital structure can not explain stock price well.展开更多
细胞因子信号转导抑制分子(suppressor of cytokine signaling,SOCS)是一类在细胞信号转导过程中发挥重要作用的负调控因子,家族成员一共有8个,主要通过抑制JAK-STAT信号通路的持续激活而调节细胞的增殖、分化和凋亡。在肿瘤的发生发展...细胞因子信号转导抑制分子(suppressor of cytokine signaling,SOCS)是一类在细胞信号转导过程中发挥重要作用的负调控因子,家族成员一共有8个,主要通过抑制JAK-STAT信号通路的持续激活而调节细胞的增殖、分化和凋亡。在肿瘤的发生发展过程中,由于SOCS家族基因启动子区CG岛超甲基化、组蛋白异常乙酰化、基因突变、基因缺失等原因导致的SOCS蛋白表达异常,使JAK-STAT被持续活化,从而导致肿瘤的发生发展与转移。本文综述了SOCS家族的发现,成员构成及分子结构,各结构域的功能及其在肿瘤发生发展等方面的最新进展。由于SOCS在肿瘤发生、发展方面的重要作用,SOCS分子作为信号转导途径重要的负调节因子发挥肿瘤抑制作用,使其成为肿瘤治疗的新靶标。展开更多
Prunus spinulosa(2n=4x=32)is an evergreen species of significantmedicinal usage and ecological value.However,the lacking of a high-quality genome of P.spinulosa has obstructed further exploration of its ecological stu...Prunus spinulosa(2n=4x=32)is an evergreen species of significantmedicinal usage and ecological value.However,the lacking of a high-quality genome of P.spinulosa has obstructed further exploration of its ecological study and phylogenetic relationship of Prunus.In this study,we present the first haplotype-resolved genome assembly of Prunus s.l.subgenus Laurocerasus,the tetraploid genome of P.spinulosa was phased into 32 pseudochromosomes with 4 haplotypes,the genome size of each haplotype ranged from 249.82 Mb to 259.69 Mb,and N50 fluctuatedfrom 31.35 Mb to 33.25 Mb,the protein-coding genes vary from 21,272 to 22,668.Different evaluation methods showed that the P.spinulosa genome assembly has high quality of completeness,continuity and accuracy.Being the firstcomplete genome of P.spinulosa,it provides a valuable genetic resource for the Prunus tetraploid species database and supports further functional genomic study of this species.展开更多
Construction of iridium(Ir)based active sites on certain acid stable supports now is a general strategy for the development of low-Ir OER catalysts.Atomically doped Ir in the lattice of acid stableγ-MnO_(2) has been ...Construction of iridium(Ir)based active sites on certain acid stable supports now is a general strategy for the development of low-Ir OER catalysts.Atomically doped Ir in the lattice of acid stableγ-MnO_(2) has been recently achieved,which shows high activity and stability though Ir usage was reduced more than 95%than that in current commercial proton exchange membrane water electrolyzer(PEMWE).However,the activity and stability enhancement by Ir doping inγ-MnO_(2) still remains elusive.Herein,high dispersion of iridium(up to 1.37 atom%)doping in the lattice ofγ-MnO_(2) has been achieved by optimizing the thermal decomposition of the iridium precursors.Benefiting from atomic dispersive doping of Ir,the optimized Ir-MnO_(2) catalyst shows high OER activity,as it has turnover frequency of 0.655 s^(–1) at an overpotential of 300 mV in 0.5 mol L^(-1) H_(2)SO_(4).The catalyst also shows high stability,as it can sustainably work at 100 mA cm^(-2) for 24 h.Experimental and theoretical studies reveal that Ir is preferentially doped intoβphase rather than R phase,and the Ir site is the active site for OER.The OER active site is postulated to be Ir^(5+)-O(H)-Mn^(3+)unit structure on the surface.Furthermore,Ir doping changes the potential determining step from the formation of O*to the formation of*OOH,emphasizing the promoting effect toward OER derived from Ir sites.This work not only demonstrates the possibility of achieving atomic-level doping of Ir on the surface of a support to dramatically reduce Ir usage,but also,more importantly,reveals the mechanism behind accounting for the stability and activity enhancement by Ir doping.These important findings may serve as valuable guidance for further development of more efficient,stable and cost-effective low Ir-based OER catalysts for PEMWE.展开更多
CAXA-ME软件中后置处理时没有Sodick机床,为了使CAXA-ME软件生成的数控程序能应用于知SodickMC 450加工中心,所采取的方法是:如果零件加工中只涉及到铣削加工,可以直接在CAXA-ME后置处理中增加新的机床Sodick,并完成相关代码的改变,使其...CAXA-ME软件中后置处理时没有Sodick机床,为了使CAXA-ME软件生成的数控程序能应用于知SodickMC 450加工中心,所采取的方法是:如果零件加工中只涉及到铣削加工,可以直接在CAXA-ME后置处理中增加新的机床Sodick,并完成相关代码的改变,使其与Sodick代码类型相符;如果零件加工中涉及到孔的加工,在CAXA-ME后置处理中选用FANUC机床,生成与FANUC机床一致的数控代码,然后通过自行设计开发的Sodick MC 450数控程序编辑器,使之能自动识别并提示与Sodick加工中心不一致的数控代码,用户可根据提示完成自动或手动程序修改。展开更多
基金supported by the National Natural Science Foundation of China(22178295,21706225)Natural Science Foundation of Hunan Province(2025JJ50085)Hunan Collaborative Innovation Center of New Chemical Technologies for Environmental Benignity and Efficient Resource Utilization.
文摘The new technology of direct decomposition of H_(2)S into high value-added H_(2) and S,as an alternative to the Claus process in industry,is an ideal route that can not only deal with toxic and abundant H_(2)S waste gas but also recover clean energy H_(2),which has significant socio-economic and ecological advantages.However,the highly effective decomposition of H_(2)S at low temperatures is still a great challenge,because of the stringent thermodynamic equilibrium constraints(only 20% even at high temperature of 1010℃).Conventional microwave catalysts exhibit unsatisfactory performance at low temperatures(below 600℃).Herein,Mo_(2)C@CeO_(2) catalysts with a core-shell structure were successfully developed for robust microwave catalytic decomposition of H_(2)S at low temperatures.Two carbon precursors,para-phenylenediamine(Mo_(2)C-p)and meta-phenylenediamine(Mo_(2)C-m),were employed to tailor Mo_(2)C configurations.Remarkably,the H_(2)S conversion of Mo_(2)C-p@CeO_(2) catalyst at a low temperature of 550℃ is as high as 92.1%,which is much higher than the H_(2)S equilibrium conversion under the conventional thermal conditions(2.6% at 550℃).To our knowledge,this represents the most active catalyst for microwave catalytic decomposition of H_(2)S at low temperature of 550℃.Notably,Mo_(2)C-p demonstrated superior intrinsic activity(84%)compared to Mo_(2)C-m(6.4%),with XPS analysis revealing that its enhanced performance stems from a higher concentration of Mo_(2+)active sites.This work presents a substitute approach for the efficient utilization of H_(2)S waste gas and opens up a novel avenue for the rational design of microwave catalysts for microwave catalytic reaction at low-temperature.
文摘This paper establishes a experiential model about stock price of Chinese listed company by using Feltham Ohlson stock option theory and model, and examines how listed company accounting statement data of China stock market from 1993 to 2001 affect listed company stock price. It also studies the influence of company growth, capital structure,company core assets profitability and the scale of floating stock on stock price. The result demonstrates that accounting earnings, net assets, the growth of company profitability, company core assets profitability,company scale and the scale of floating stock not only relate with stock price, but also can explain stock price. But capital structure can not explain stock price well.
文摘细胞因子信号转导抑制分子(suppressor of cytokine signaling,SOCS)是一类在细胞信号转导过程中发挥重要作用的负调控因子,家族成员一共有8个,主要通过抑制JAK-STAT信号通路的持续激活而调节细胞的增殖、分化和凋亡。在肿瘤的发生发展过程中,由于SOCS家族基因启动子区CG岛超甲基化、组蛋白异常乙酰化、基因突变、基因缺失等原因导致的SOCS蛋白表达异常,使JAK-STAT被持续活化,从而导致肿瘤的发生发展与转移。本文综述了SOCS家族的发现,成员构成及分子结构,各结构域的功能及其在肿瘤发生发展等方面的最新进展。由于SOCS在肿瘤发生、发展方面的重要作用,SOCS分子作为信号转导途径重要的负调节因子发挥肿瘤抑制作用,使其成为肿瘤治疗的新靶标。
基金supported by the National Natural Science Foundation of China(Grant No.32570239)Key Technology Research and Development Program of Zhejiang Province(Grant No.2023C03138).
文摘Prunus spinulosa(2n=4x=32)is an evergreen species of significantmedicinal usage and ecological value.However,the lacking of a high-quality genome of P.spinulosa has obstructed further exploration of its ecological study and phylogenetic relationship of Prunus.In this study,we present the first haplotype-resolved genome assembly of Prunus s.l.subgenus Laurocerasus,the tetraploid genome of P.spinulosa was phased into 32 pseudochromosomes with 4 haplotypes,the genome size of each haplotype ranged from 249.82 Mb to 259.69 Mb,and N50 fluctuatedfrom 31.35 Mb to 33.25 Mb,the protein-coding genes vary from 21,272 to 22,668.Different evaluation methods showed that the P.spinulosa genome assembly has high quality of completeness,continuity and accuracy.Being the firstcomplete genome of P.spinulosa,it provides a valuable genetic resource for the Prunus tetraploid species database and supports further functional genomic study of this species.
文摘Construction of iridium(Ir)based active sites on certain acid stable supports now is a general strategy for the development of low-Ir OER catalysts.Atomically doped Ir in the lattice of acid stableγ-MnO_(2) has been recently achieved,which shows high activity and stability though Ir usage was reduced more than 95%than that in current commercial proton exchange membrane water electrolyzer(PEMWE).However,the activity and stability enhancement by Ir doping inγ-MnO_(2) still remains elusive.Herein,high dispersion of iridium(up to 1.37 atom%)doping in the lattice ofγ-MnO_(2) has been achieved by optimizing the thermal decomposition of the iridium precursors.Benefiting from atomic dispersive doping of Ir,the optimized Ir-MnO_(2) catalyst shows high OER activity,as it has turnover frequency of 0.655 s^(–1) at an overpotential of 300 mV in 0.5 mol L^(-1) H_(2)SO_(4).The catalyst also shows high stability,as it can sustainably work at 100 mA cm^(-2) for 24 h.Experimental and theoretical studies reveal that Ir is preferentially doped intoβphase rather than R phase,and the Ir site is the active site for OER.The OER active site is postulated to be Ir^(5+)-O(H)-Mn^(3+)unit structure on the surface.Furthermore,Ir doping changes the potential determining step from the formation of O*to the formation of*OOH,emphasizing the promoting effect toward OER derived from Ir sites.This work not only demonstrates the possibility of achieving atomic-level doping of Ir on the surface of a support to dramatically reduce Ir usage,but also,more importantly,reveals the mechanism behind accounting for the stability and activity enhancement by Ir doping.These important findings may serve as valuable guidance for further development of more efficient,stable and cost-effective low Ir-based OER catalysts for PEMWE.
文摘CAXA-ME软件中后置处理时没有Sodick机床,为了使CAXA-ME软件生成的数控程序能应用于知SodickMC 450加工中心,所采取的方法是:如果零件加工中只涉及到铣削加工,可以直接在CAXA-ME后置处理中增加新的机床Sodick,并完成相关代码的改变,使其与Sodick代码类型相符;如果零件加工中涉及到孔的加工,在CAXA-ME后置处理中选用FANUC机床,生成与FANUC机床一致的数控代码,然后通过自行设计开发的Sodick MC 450数控程序编辑器,使之能自动识别并提示与Sodick加工中心不一致的数控代码,用户可根据提示完成自动或手动程序修改。
基金supported by the National Institute on Aging(R03AG064374)the Ohio State University Comprehensive Cancer Center+3 种基金supported by the National Institute on Aging(R01AG059711)supported by the National Institute on Aging(R03AG056439,K76AG064431)the University of California,San Francisco Helen Diller Family Comprehensive Cancer CenterThe Cancer and Aging Research Group also supported this review(R33AG059206).
文摘癌症常见于老年人。初诊为恶性肿瘤的患者的中位年龄为66岁,癌症相关死亡的中位年龄为72岁[1]。老年人是癌症患病率增长最快的人群之一[2]。免疫治疗的发展,尤其是免疫检查点抑制剂(immune checkpoint inhibitors,ICIs)的问世,彻底改变了所有年龄层包括老年人在内的肿瘤患者的常规治疗方案。细胞毒性T淋巴细胞相关抗原4、程序性死亡受体1(programmed death receptor-1,PD-1)及其配体(programmed death-ligand 1,PD-L1)的抑制剂可改善多种肿瘤患者的总生存期(overall survival,OS)[3],且部分患者可获得持续缓解[4]。
