核酸适配体指通过指数富集的配体系统进化技术(systematic evolution of ligands by exponential enrichment,SELEX)筛选获得的单链DNA或RNA分子,具备特异性识别并结合金属离子、小分子、蛋白质、细胞等靶标特性。这类分子凭借低分子量...核酸适配体指通过指数富集的配体系统进化技术(systematic evolution of ligands by exponential enrichment,SELEX)筛选获得的单链DNA或RNA分子,具备特异性识别并结合金属离子、小分子、蛋白质、细胞等靶标特性。这类分子凭借低分子量、靶标范围广、合成便捷、低免疫原性和高稳定性等优势,在癌症领域展现出巨大的应用潜力。目前,核酸适配体被广泛应用于电化学、比色、荧光和化学发光等生物传感器技术领域,助力实现肿瘤标志物的精准检测,并提升癌症诊断工具的灵敏度。此外,核酸适配体通过靶向递送药物、阻断免疫检查点等方式为癌症治疗提供了新策略。本文系统综述了核酸适配体的基本特性及其在生物传感技术和癌症治疗应用的新进展。展开更多
Flexible photodetector(PD)arrays have the potential to replace the rods and cones in the retina,converting external light signals into electrical signals and offering hope for blind patients to regain vision.However,i...Flexible photodetector(PD)arrays have the potential to replace the rods and cones in the retina,converting external light signals into electrical signals and offering hope for blind patients to regain vision.However,issues like discontinuous electrode surfaces and incompletely crystallized perovskites can cause cracks and degrade the performance of flexible PDs during repeated bending,hindering their development and applications.In this study,we employ a combination of radio frequency magnetron sputtering and angular ion beam polishing to achieve an ultrathin,ultrasmooth platinum(Pt)electrode film(UTPF)with a thickness of less than 10 nm.Building on this,a vapor deposition method with dynamically regulated evaporation rates is developed to obtain a dense-gradient PbI_(2)precursor.This funnel-shaped vertical structure precursor facilitates the penetration of CH_(3)NH_(3)I solution,ultimately resulting in a dense and uniform perovskite film with large grains and strong interfacial bonding with UTPF.The results indicate that the flexible PD arrays exhibit excellent optoelectronic performances,characterized by high sensitivity,detectivity and a large on/off current ratio.Furthermore,benefitting from their exceptional flexibility and electrical stability,the devices retain 92.53%of the original photocurrent after 4000 bending cycles at large angles.Notably,the integrated 10×10 flexible PD arrays demonstrate good uniformity in dark current and photocurrent,along with high imaging resolution,showing the reliable imaging capabilities of the flexible arrays and their potential applications in artificial retina.展开更多
文摘核酸适配体指通过指数富集的配体系统进化技术(systematic evolution of ligands by exponential enrichment,SELEX)筛选获得的单链DNA或RNA分子,具备特异性识别并结合金属离子、小分子、蛋白质、细胞等靶标特性。这类分子凭借低分子量、靶标范围广、合成便捷、低免疫原性和高稳定性等优势,在癌症领域展现出巨大的应用潜力。目前,核酸适配体被广泛应用于电化学、比色、荧光和化学发光等生物传感器技术领域,助力实现肿瘤标志物的精准检测,并提升癌症诊断工具的灵敏度。此外,核酸适配体通过靶向递送药物、阻断免疫检查点等方式为癌症治疗提供了新策略。本文系统综述了核酸适配体的基本特性及其在生物传感技术和癌症治疗应用的新进展。
基金supported by the National Natural Science Foundation of China(62375081,U22A20138,52372146,62090035,52221001,and 52402181)the National Key R&D Program of China(2022YFA1204300 and 2022YFA1402501).
文摘Flexible photodetector(PD)arrays have the potential to replace the rods and cones in the retina,converting external light signals into electrical signals and offering hope for blind patients to regain vision.However,issues like discontinuous electrode surfaces and incompletely crystallized perovskites can cause cracks and degrade the performance of flexible PDs during repeated bending,hindering their development and applications.In this study,we employ a combination of radio frequency magnetron sputtering and angular ion beam polishing to achieve an ultrathin,ultrasmooth platinum(Pt)electrode film(UTPF)with a thickness of less than 10 nm.Building on this,a vapor deposition method with dynamically regulated evaporation rates is developed to obtain a dense-gradient PbI_(2)precursor.This funnel-shaped vertical structure precursor facilitates the penetration of CH_(3)NH_(3)I solution,ultimately resulting in a dense and uniform perovskite film with large grains and strong interfacial bonding with UTPF.The results indicate that the flexible PD arrays exhibit excellent optoelectronic performances,characterized by high sensitivity,detectivity and a large on/off current ratio.Furthermore,benefitting from their exceptional flexibility and electrical stability,the devices retain 92.53%of the original photocurrent after 4000 bending cycles at large angles.Notably,the integrated 10×10 flexible PD arrays demonstrate good uniformity in dark current and photocurrent,along with high imaging resolution,showing the reliable imaging capabilities of the flexible arrays and their potential applications in artificial retina.
