目的对行人工全膝关节置换术(total knee arthroplasty,TKA)的膝骨关节病患者进行长期随访,评估远期假体生存率和临床效果。方法本研究基于既往一项已完成随访的队列研究。回顾性收集1993—2002年北京协和医院接受初次TKA术且随访20年...目的对行人工全膝关节置换术(total knee arthroplasty,TKA)的膝骨关节病患者进行长期随访,评估远期假体生存率和临床效果。方法本研究基于既往一项已完成随访的队列研究。回顾性收集1993—2002年北京协和医院接受初次TKA术且随访20年以上的膝骨关节病(包括膝骨关节炎和膝关节类风湿关节炎)患者的临床资料,并于2024年11月10日对入组患者统一进行1次末次随访。采用Kaplan-Meier曲线评估假体生存率。比较患者术前、术后10年、末次随访时特种外科医院(hospital for special surgery,HSS)评分和屈伸关节活动度(range of motion,ROM),以评价TKA临床疗效,并在末次随访时采用Likert量表评估患者满意度。结果1993—2002年间,北京协和医院行初次TKA术且随访10年以上的患者共226例(246膝)。其中104例(131膝)获得末次随访并纳入本研究分析,包括21例(24膝)假体在位,18例(18膝)因各种原因行二次手术,65例(89膝)因非TKA术原因死亡。截至末次随访,平均随访≥20年的患者共29例(35膝),完成HSS评分、ROM测定及患者满意度评价者12例(16膝)。Kaplan-Meier曲线显示,10年、15年、20年、25年假体生存率分别为93.6%、92.4%、89.8%、71.8%。末次随访时HSS评分虽较术后随访10年时有所降低[(84.69±11.03)分比(95.25±13.32)分,P<0.05],但较术前显著改善[(84.69±11.03)分比(58.75±7.19)分,P<0.05]。术前、术后随访10年、末次随访时膝关节屈伸ROM分别为(93.44±17.30)°、(101.88±13.33)°、(91.56±15.98)°,组间比较差异无统计学意义(P>0.05)。患者满意度方面,10膝(62.50%)评分为4分(非常满意),余6膝(37.50%)均为3分(满意),满意度为100%。结论TKA治疗膝骨关节病远期假体生存率高,膝关节功能改善显著,患者满意度高。展开更多
The synthesis of isoamyl butyrate with isoamyl alcohol and butyric acid as reactants and rare-earth solid superacid SO42-/TiO2/La3+ as catalyst had been studied. The influent actors of reaction were investigated. The ...The synthesis of isoamyl butyrate with isoamyl alcohol and butyric acid as reactants and rare-earth solid superacid SO42-/TiO2/La3+ as catalyst had been studied. The influent actors of reaction were investigated. The results showed that the appropriate conditions should be: Weight of catalyst was 0. 5g (weight of butyric acid if 0. 2mol); molar ratio of isoamyl alcohol to butyric acid was 1. 8: 1; reaction time was 2. 0 h; the taking water reagent (Toluene) was 15mL. The yield of isoamyl butyrate was about 99. 0%.展开更多
The synthesis of butyl heptanoate with n butanol and heptanoic acid as reactants and the rare earth solid super acid SO 2- 4/TiO 2/La 3+ as catalyst had been sutdied.The effects of various actors on the reaction were ...The synthesis of butyl heptanoate with n butanol and heptanoic acid as reactants and the rare earth solid super acid SO 2- 4/TiO 2/La 3+ as catalyst had been sutdied.The effects of various actors on the reaction were investigated.The results showed that the appropriate conditions should be:Weight of catalyst is 0.5g(weight of heptanoic acid is 0.2mol);molar ratio of n butanol to heptanoic acid was 1.8∶1;reaction time was 2.0h;dehydrating agent (Toluene) being 15ml.The yield of butyl heptanoate was about 99.2%.展开更多
文摘目的对行人工全膝关节置换术(total knee arthroplasty,TKA)的膝骨关节病患者进行长期随访,评估远期假体生存率和临床效果。方法本研究基于既往一项已完成随访的队列研究。回顾性收集1993—2002年北京协和医院接受初次TKA术且随访20年以上的膝骨关节病(包括膝骨关节炎和膝关节类风湿关节炎)患者的临床资料,并于2024年11月10日对入组患者统一进行1次末次随访。采用Kaplan-Meier曲线评估假体生存率。比较患者术前、术后10年、末次随访时特种外科医院(hospital for special surgery,HSS)评分和屈伸关节活动度(range of motion,ROM),以评价TKA临床疗效,并在末次随访时采用Likert量表评估患者满意度。结果1993—2002年间,北京协和医院行初次TKA术且随访10年以上的患者共226例(246膝)。其中104例(131膝)获得末次随访并纳入本研究分析,包括21例(24膝)假体在位,18例(18膝)因各种原因行二次手术,65例(89膝)因非TKA术原因死亡。截至末次随访,平均随访≥20年的患者共29例(35膝),完成HSS评分、ROM测定及患者满意度评价者12例(16膝)。Kaplan-Meier曲线显示,10年、15年、20年、25年假体生存率分别为93.6%、92.4%、89.8%、71.8%。末次随访时HSS评分虽较术后随访10年时有所降低[(84.69±11.03)分比(95.25±13.32)分,P<0.05],但较术前显著改善[(84.69±11.03)分比(58.75±7.19)分,P<0.05]。术前、术后随访10年、末次随访时膝关节屈伸ROM分别为(93.44±17.30)°、(101.88±13.33)°、(91.56±15.98)°,组间比较差异无统计学意义(P>0.05)。患者满意度方面,10膝(62.50%)评分为4分(非常满意),余6膝(37.50%)均为3分(满意),满意度为100%。结论TKA治疗膝骨关节病远期假体生存率高,膝关节功能改善显著,患者满意度高。
文摘The synthesis of isoamyl butyrate with isoamyl alcohol and butyric acid as reactants and rare-earth solid superacid SO42-/TiO2/La3+ as catalyst had been studied. The influent actors of reaction were investigated. The results showed that the appropriate conditions should be: Weight of catalyst was 0. 5g (weight of butyric acid if 0. 2mol); molar ratio of isoamyl alcohol to butyric acid was 1. 8: 1; reaction time was 2. 0 h; the taking water reagent (Toluene) was 15mL. The yield of isoamyl butyrate was about 99. 0%.
文摘The synthesis of butyl heptanoate with n butanol and heptanoic acid as reactants and the rare earth solid super acid SO 2- 4/TiO 2/La 3+ as catalyst had been sutdied.The effects of various actors on the reaction were investigated.The results showed that the appropriate conditions should be:Weight of catalyst is 0.5g(weight of heptanoic acid is 0.2mol);molar ratio of n butanol to heptanoic acid was 1.8∶1;reaction time was 2.0h;dehydrating agent (Toluene) being 15ml.The yield of butyl heptanoate was about 99.2%.
