目的:分析Sternberg管未闭的病因、临床特点,并指导临床诊断及治疗。方法:收集近1年本医疗组治疗Sternberg管未闭患者的临床资料,并检索国内外数据库收集相关病例进行回顾性分析。结果:2例病例均有明确Sternberg管未闭伴脑膜脑膨出的影...目的:分析Sternberg管未闭的病因、临床特点,并指导临床诊断及治疗。方法:收集近1年本医疗组治疗Sternberg管未闭患者的临床资料,并检索国内外数据库收集相关病例进行回顾性分析。结果:2例病例均有明确Sternberg管未闭伴脑膜脑膨出的影像学特征,经过手术治疗后未见明显脑脊液漏表现。文献检索共得相关研究22篇,其中病例为51例,以自发性脑脊液鼻漏为主要症状,均有明确蝶窦骨质缺陷,手术治疗预后良好。结论:Sternberg管人群中发病率低,主要引起不明原因的脑脊液鼻漏。其临床诊断困难,但手术可治愈,预后好,复发率低。Objective: To analyze the etiology and clinical characteristics of patent Sternberg’s Canal, and to guide clinical diagnosis and treatment. Method: We collect clinical data of patients with patent Sternberg’s Canal treated in our medical group in recent years and retrieve relevant cases from Chinese and foreign databases for retrospective analysis. Result: Both two cases had explicit imaging features of patent Sternberg’s Canal along with meningoencephalocele. No obvious cerebrospinal fluid leakage was observed after surgical treatment. A total of 22 relevant studies were obtained through literature search, including 51 cases, with spontaneous cerebrospinal fluid rhinorrhea as the main symptom. All of them had clear sphenoid sinus bone defects and had good prognosis after taking surgical treatment. Conclusion: In epidemiology, the incidence rate in Sternberg’s Canal is low, which mainly causes cerebrospinal fluid rhinorrhea of unknown causes. It is difficult to make clinical diagnosis, but it can be cured by surgery, with good prognosis and low recurrence rate.展开更多
目的:在社区老年2型糖尿病人群中评估口服二甲双胍年限对老年人认知功能的影响。方法:选取青岛市泊里社区体检的1114名65以上的口服二甲双胍的糖尿病患者为研究对象,收集年龄、体质指数(BMI)、学历、是否吸烟,高血压病史、重大精神疾病...目的:在社区老年2型糖尿病人群中评估口服二甲双胍年限对老年人认知功能的影响。方法:选取青岛市泊里社区体检的1114名65以上的口服二甲双胍的糖尿病患者为研究对象,收集年龄、体质指数(BMI)、学历、是否吸烟,高血压病史、重大精神疾病史、脑血管病史、谷丙转氨酶、谷草转氨酶、肌酐、总胆固醇、甘油三酯、低密度脂蛋白、高密度脂蛋白、空腹血糖资料。用简明认知功能量表(MMSE)评估认知功能,以是否患有认知障碍为因变量,比较收集的资料是否与认知障碍有相关性,并应用logistic回归分析二甲双胍治疗年限对认知功能的影响。结果:认知障碍和非认知障碍的老年2型糖尿病患者相比,体质指数、收缩压、舒张压、谷草转氨酶、谷丙转氨酶、肌酐、总胆固醇、甘油三酯、空腹血糖、是否吸烟、是否高血压无统计学差异(p > 0.05);与非认知障碍组相比,认知障碍组的年龄、低密度脂蛋白、高密度脂蛋白更高(p Objective: To evaluate the effect of the duration of oral metformin treatment on cognitive function in elderly patients with type 2 diabetes in a community setting. Methods: This study included 1114 diabetic patients aged 65 and above taking oral metformin from the Poli community in Qingdao. Data collected included age, body mass index (BMI), education level, smoking status, history of hypertension, major psychiatric disorders, cerebrovascular disease, levels of alanine transaminase (ALT), aspartate transaminase (AST), creatinine, total cholesterol, triglycerides, low-density lipoprotein (LDL), high-density lipoprotein (HDL), and fasting blood glucose. Cognitive function was assessed using the Mini-Mental State Examination (MMSE). Cognitive impairment was used as the dependent variable to analyze the correlation between the collected data and cognitive impairment, and logistic regression was applied to evaluate the effect of the duration of metformin treatment on cognitive function. Results: Comparing elderly type 2 diabetic patients with and without cognitive impairment, no significant differences were found in BMI, systolic blood pressure, diastolic blood pressure, AST, ALT, creatinine, total cholesterol, triglycerides, fasting blood glucose, smoking status, or history of hypertension (p > 0.05). The cognitive impairment group had significantly higher age, LDL, and HDL compared to the non-cognitive impairment group (p < 0.05). Oral metformin treatment for 10 years or more showed a statistically significant protective effect on cognitive function in elderly type 2 diabetic patients. Conclusion: The neurocognitive protective effect of metformin is influenced by the duration of treatment. The key to preventing cognitive impairment and dementia in type 2 diabetic patients lies in addressing traditional risk factors.展开更多
文摘目的:分析Sternberg管未闭的病因、临床特点,并指导临床诊断及治疗。方法:收集近1年本医疗组治疗Sternberg管未闭患者的临床资料,并检索国内外数据库收集相关病例进行回顾性分析。结果:2例病例均有明确Sternberg管未闭伴脑膜脑膨出的影像学特征,经过手术治疗后未见明显脑脊液漏表现。文献检索共得相关研究22篇,其中病例为51例,以自发性脑脊液鼻漏为主要症状,均有明确蝶窦骨质缺陷,手术治疗预后良好。结论:Sternberg管人群中发病率低,主要引起不明原因的脑脊液鼻漏。其临床诊断困难,但手术可治愈,预后好,复发率低。Objective: To analyze the etiology and clinical characteristics of patent Sternberg’s Canal, and to guide clinical diagnosis and treatment. Method: We collect clinical data of patients with patent Sternberg’s Canal treated in our medical group in recent years and retrieve relevant cases from Chinese and foreign databases for retrospective analysis. Result: Both two cases had explicit imaging features of patent Sternberg’s Canal along with meningoencephalocele. No obvious cerebrospinal fluid leakage was observed after surgical treatment. A total of 22 relevant studies were obtained through literature search, including 51 cases, with spontaneous cerebrospinal fluid rhinorrhea as the main symptom. All of them had clear sphenoid sinus bone defects and had good prognosis after taking surgical treatment. Conclusion: In epidemiology, the incidence rate in Sternberg’s Canal is low, which mainly causes cerebrospinal fluid rhinorrhea of unknown causes. It is difficult to make clinical diagnosis, but it can be cured by surgery, with good prognosis and low recurrence rate.
文摘目的:在社区老年2型糖尿病人群中评估口服二甲双胍年限对老年人认知功能的影响。方法:选取青岛市泊里社区体检的1114名65以上的口服二甲双胍的糖尿病患者为研究对象,收集年龄、体质指数(BMI)、学历、是否吸烟,高血压病史、重大精神疾病史、脑血管病史、谷丙转氨酶、谷草转氨酶、肌酐、总胆固醇、甘油三酯、低密度脂蛋白、高密度脂蛋白、空腹血糖资料。用简明认知功能量表(MMSE)评估认知功能,以是否患有认知障碍为因变量,比较收集的资料是否与认知障碍有相关性,并应用logistic回归分析二甲双胍治疗年限对认知功能的影响。结果:认知障碍和非认知障碍的老年2型糖尿病患者相比,体质指数、收缩压、舒张压、谷草转氨酶、谷丙转氨酶、肌酐、总胆固醇、甘油三酯、空腹血糖、是否吸烟、是否高血压无统计学差异(p > 0.05);与非认知障碍组相比,认知障碍组的年龄、低密度脂蛋白、高密度脂蛋白更高(p Objective: To evaluate the effect of the duration of oral metformin treatment on cognitive function in elderly patients with type 2 diabetes in a community setting. Methods: This study included 1114 diabetic patients aged 65 and above taking oral metformin from the Poli community in Qingdao. Data collected included age, body mass index (BMI), education level, smoking status, history of hypertension, major psychiatric disorders, cerebrovascular disease, levels of alanine transaminase (ALT), aspartate transaminase (AST), creatinine, total cholesterol, triglycerides, low-density lipoprotein (LDL), high-density lipoprotein (HDL), and fasting blood glucose. Cognitive function was assessed using the Mini-Mental State Examination (MMSE). Cognitive impairment was used as the dependent variable to analyze the correlation between the collected data and cognitive impairment, and logistic regression was applied to evaluate the effect of the duration of metformin treatment on cognitive function. Results: Comparing elderly type 2 diabetic patients with and without cognitive impairment, no significant differences were found in BMI, systolic blood pressure, diastolic blood pressure, AST, ALT, creatinine, total cholesterol, triglycerides, fasting blood glucose, smoking status, or history of hypertension (p > 0.05). The cognitive impairment group had significantly higher age, LDL, and HDL compared to the non-cognitive impairment group (p < 0.05). Oral metformin treatment for 10 years or more showed a statistically significant protective effect on cognitive function in elderly type 2 diabetic patients. Conclusion: The neurocognitive protective effect of metformin is influenced by the duration of treatment. The key to preventing cognitive impairment and dementia in type 2 diabetic patients lies in addressing traditional risk factors.
