目的分析急性期单侧突发性聋患者水平方位声源定位能力及其影响因素。方法同期纳入病程在3周内的单侧突发性聋患者110例和正常听力对照组20例,完成角度辨别测试和角度识别测试,采用的刺激声为言语声(65 dB SPL)。获得最小可听角(minimum...目的分析急性期单侧突发性聋患者水平方位声源定位能力及其影响因素。方法同期纳入病程在3周内的单侧突发性聋患者110例和正常听力对照组20例,完成角度辨别测试和角度识别测试,采用的刺激声为言语声(65 dB SPL)。获得最小可听角(minimum audible angle,MAA)和均方根误差(root-mean-square error,RMSE),分别计算患侧和健侧RMSE。依据WHO(2021)听力损失分级标准,对患耳纯音平均听阈(pure-tone average,PTA)进行分组,并记录患耳各频率最佳残余听力。结果单侧突发性聋患者在声源定位任务中的表现差异较大,部分表现接近正常水平,而部分则完全丧失声源定位能力。中度听力损失组(PTA≥35 dB HL)较正常听力组RMSE显著增加(P<0.01),中重度听力损失组(PTA≥50 dB HL)较正常听力组MAA差异具有统计学意义(P<0.001)。重度及以上组患者患侧RMSE较健侧显著增大。回归分析显示,患耳各频率最佳残余听力是影响MAA(R^(2)=0.572,P<0.001)、RMSE(R^(2)=0.768,P<0.001)的最主要因素。结论急性期单侧突发性聋患者的水平方位声源定位能力个体差异较大,当患侧PTA达到中度听力损失时,定位较正常听力者显著下降。患耳各频率最佳残余听力是影响声源定位能力的关键因素。展开更多
OBJECTIVE To investigate the expression of the high mobility group boxl（HMGB1） in human cervical squamous epithelial carcinoma （CSEC） and to explore the relationship of HMGB1 expression to the differentiation degr...OBJECTIVE To investigate the expression of the high mobility group boxl（HMGB1） in human cervical squamous epithelial carcinoma （CSEC） and to explore the relationship of HMGB1 expression to the differentiation degree, size, invasion and metastasis of CSEC. METHODS Immunohistochemical staining of tissue microarrays and Western blot analysis were conducted to detect the expression of HMGB1 in the following tissue samples： 30 carcinoma in situ, 90 invasive CSEC without metastasis, 30 invasive CSEC with metastasis, 30 cases of normal cervical squamous epithelia. RESULTS The positive-expression rate of HMGB1 was 58.7% （88/150） in CSEC, showing a significant difference compared to normal cervical squamous epithelia. The expression of HMGB1 was correlated with tumor size, invasion and metastasis of CSEC （respectively, P〈0.01）, but had no relationship with the degree of differentiation （P〉0.05）. CONCLUSION The over-expression of HMGB1 in CSEC might be a useful parameter as an indication of tumor invasion, metastasis, prognosis and overall biological behavior of human CSEC, as well as a noval target site for gene therapy.展开更多
文摘目的分析急性期单侧突发性聋患者水平方位声源定位能力及其影响因素。方法同期纳入病程在3周内的单侧突发性聋患者110例和正常听力对照组20例,完成角度辨别测试和角度识别测试,采用的刺激声为言语声(65 dB SPL)。获得最小可听角(minimum audible angle,MAA)和均方根误差(root-mean-square error,RMSE),分别计算患侧和健侧RMSE。依据WHO(2021)听力损失分级标准,对患耳纯音平均听阈(pure-tone average,PTA)进行分组,并记录患耳各频率最佳残余听力。结果单侧突发性聋患者在声源定位任务中的表现差异较大,部分表现接近正常水平,而部分则完全丧失声源定位能力。中度听力损失组(PTA≥35 dB HL)较正常听力组RMSE显著增加(P<0.01),中重度听力损失组(PTA≥50 dB HL)较正常听力组MAA差异具有统计学意义(P<0.001)。重度及以上组患者患侧RMSE较健侧显著增大。回归分析显示,患耳各频率最佳残余听力是影响MAA(R^(2)=0.572,P<0.001)、RMSE(R^(2)=0.768,P<0.001)的最主要因素。结论急性期单侧突发性聋患者的水平方位声源定位能力个体差异较大,当患侧PTA达到中度听力损失时,定位较正常听力者显著下降。患耳各频率最佳残余听力是影响声源定位能力的关键因素。
文摘OBJECTIVE To investigate the expression of the high mobility group boxl（HMGB1） in human cervical squamous epithelial carcinoma （CSEC） and to explore the relationship of HMGB1 expression to the differentiation degree, size, invasion and metastasis of CSEC. METHODS Immunohistochemical staining of tissue microarrays and Western blot analysis were conducted to detect the expression of HMGB1 in the following tissue samples： 30 carcinoma in situ, 90 invasive CSEC without metastasis, 30 invasive CSEC with metastasis, 30 cases of normal cervical squamous epithelia. RESULTS The positive-expression rate of HMGB1 was 58.7% （88/150） in CSEC, showing a significant difference compared to normal cervical squamous epithelia. The expression of HMGB1 was correlated with tumor size, invasion and metastasis of CSEC （respectively, P〈0.01）, but had no relationship with the degree of differentiation （P〉0.05）. CONCLUSION The over-expression of HMGB1 in CSEC might be a useful parameter as an indication of tumor invasion, metastasis, prognosis and overall biological behavior of human CSEC, as well as a noval target site for gene therapy.
