血管紧张素转化酶基因多态性与妊娠高血压综合征的关系被引量：4

Relationship between Insertion/deletion Polymorphism of Angiotensin Converting Enzyme Gene and Pregnancy-induced Hypertension Syndrome

暂未订购

导出

摘要目的 :探讨血管紧张素转化酶 (ACE)基因插入(I)/缺失 (D)多态性与妊娠高血压综合征 (妊高征 )的关系。方法 :应用聚合酶链反应 (PCR)方法检测41例妊高征患者和50例正常妊娠者的ACE基因型 ,同时检测血浆ACE水平。结果 :妊高征组的DD基因型频率及D等位基因频率分别为39 %和61 % ,均高于对照组的相应频率18 %和38 % ,差别有统计学意义 (P<0.05)。DD基因型的ACE活性显著高于其他2种基因型。结论 :ACE基因缺失多态性可能为妊高征发病的重要遗传因素 ,ACE活性受到基因的调控。 Objective:To identify the relationship between the insertion/deletion(I/D)polymorphism of anˉgiotensin converting enzyme(ACE)gene and pregnancy-induced hypertension syndrome(PIH).Methods:ACE genotype was examined by polymerase chain reaction(PCR)in41patients with PIH and50normal conˉtrols.The activity of plasma ACE was measured simultaneously.Results:The frequency of DD genotype and the frequency of deletion allele in PIH were39%and61%respectively.They were higher than those in the normal controls(P<0.05).The activity of ACE in the population with DD genotype was higher than the others.Conclusion:The DD genotype of ACE gene is probably an important hereditary factor of PIH.ACE activity can be controlled by the gene for the cause of higher activity of DD genotype.

作者王金和步天栩王艳娟程佩兰

机构地区天津医科大学总医院生化科

出处《天津医药》 CAS 北大核心 2004年第6期339-341,F003,共4页 Tianjin Medical Journal

关键词血管紧张素转化酶基因多态性妊娠高血压综合征聚合酶链反应基因缺失 pregnancy complications,cardiovascular polymerase chain reaction gene deletion polymorphism(genetics)

分类号 R714.246 [医药卫生—妇产科学]

引文网络
相关文献

参考文献8

1乐杰.妇产科学（第5版）[M].北京:人民卫生出版社,2001.139.
2Tsutaya S, Kitaya H, Saito Y, et al. Angiotensin converting enzyme gene polymorphism and its enzyme activity in serum in young Japanese females. Tohoku J Exp Med, 1997, 182:151 -155.
3Lahiri DK, Schnabel B. DNA isolation by a rapid method from human blood samples: effects of MgCI2, EDTA, storage time, and temperature on DNA yield and quality. Biochem Genet, 1993,31(7 - 8) : 321 - 328.
4王桂华,化凤君,牛建青,李宏芬,戴琪,王健,张蕴霞,刘玉光,张丽华,梁维敏,刘静宜,糜若然.血管紧张素转换酶基因多态性与妊高征的关系[J].中华妇产科杂志,1999,34(2):116-116. 被引量：4
5Seremak - Mrozikiewicz A, Drews K, Chmara E, et al.Polymorphism of gene angiotensin converting enzyme in pregnancy induced hypertension. Ginekol Pol, 2001, 72(8): 605-610.
6袁栎,刘丽,王洪波,于立身,罗超权,左龙蛟.飞行(学)员ACE基因的多态性[J].中国生物化学与分子生物学报,2002,18(3):384-387. 被引量：5
7高秀艳,张为远,吴志华,丘晓红,许静,马淑凤,李满春.妊娠高血压综合征家系血管紧张素转换酶基因缺失多态性研究[J].中华妇产科杂志,2003,38(5):302-303. 被引量：11
8Ueda S, Heeley RP, Less KR, et al. Mistyping of the human angiotensin-converting enzyme gene polymorphism: frequency, causes and possible methods to avoid errors in typing. J Mol Endocrinol, 1996, 17(1) : 27.

二级参考文献18

1张延杰.血管紧张素转换酶抑制剂与心血管病[J].心血管病学进展,1996,2:67-70.
2[3]Duru K, Fairow S, Wang J M, Lochette W, Kurtz T. Frequency of a deletion polymorphism in the gene for angiotensin converting enzyme is associated in African-American with hypertension. Am J Hypertens, 1994,7: 759 ～ 762
3[4]Chiu K C and Mcarthy J E. The insertion allele at the angiotensin I-converting enzyme gene locus is associated with insulin resistence. Metabolism, 1997,46(4) :395 ～ 399
4[5]Gayagay G, Yu B, Hambly B, Boston T, Hahn A, Celermajer D S, Trent R J. Elite endurance atheletes and the ACE I allele the role of genes in atheletic performance. Hum Genet, 1998,103: 48 ～ 50
5[6]Myerson S, Hemingway H, Budget R, Martin J, Humphries S, Montgoery,H.Human angiotensin I-converting enzyme gene and endurance performance. JAppl Physiol,1999,87(4) :1313 ～ 1316
6[7]Montgomery H E, Clarkson P, Dollery C M, Prasad K, Losi M A, Hemingway H,Statters D, Jubb M, Girvain M, Varnava A, World M, Deanfield J,Talmud P, McEwan J R, McKenna W J, Humphries S. Association of angiotensin-converting enzyme gene ID polymorphism with change in left ventricular mass in response to physical training. Circulation,1997,96:741 ～ 747
7[8]Montgomery H E, Clarkson P, Barnard M, Bell J, Brynes A, Dollery C,Hajnal J, Heming way H, Mercer D, Jarman P, Marshall R, Prasad K,Rayson M, Saeed N, Talmud P, Thomas L, Jub M, World M, Humphries S. Angiotensin-converting enzyme gene insertion/deletion polymorphism and response to physical training. Lancet, 1999,353:541 ～ 545
8[9]Montgomery H E, Marshall R, Hemingway H, Myerson S, Clarkson P,Dollery C, Hayward M, Holliman D E, Jubb M, World M, Thomas E L,Brynes A E, Saeed N, Barnard M, Bell J D, Prasad K, Rayson M, Talmud P J, Humphries S E. Human gene for physical performance. Nature,1998,393: 221 ～ 222
9Cooper DW, Hill JA, Chesley LC, et al. Genetic control of susceptibility to eclampsia and Omiscarriage. Br J Obstet Gynecol,1998, 95:644-653.
10Tiret L, Rigat B, Visvikis B, et al. Evidence from combined segregation and linkage analysis that a variant of the angiotensin Ⅰ conveaing enzyme (ACE)gene controls plasma ACE levels. Am J Hum Genet, 1992, 15: 197-205.