摘要
通过分析血液流变特性对病理生理变化的影响,内毒素在导致内毒素血症和多器官功能衰竭中扮演的角色,以及内毒素血症中血液流变特性的变化,由此提示革兰氏阴性菌产生的内毒素与血液流变学特性变化之间关系密切,因此及时降低血液中内毒素的水平对于有效治疗内毒素血症及相关病症具有重大意义。临床上对于内毒素血症的治疗缺乏有效药物,利用固定化多粘菌素B聚苯乙烯微球进行血液灌流可特异地吸附血液中内毒素,降低血液中内毒素的水平,改善血液流变学特性,在急救医学治疗中具有广阔前景。
Effects of hemorheology on pathogenesis and key role endotoxin playing in endotoxaemia as well as Multiple Organ Dysfunction Syndrome (MODS) have been discussed. The close relationship between endotoxin in blood and hemorheological characteristics has been discovered through discovering hemorheology in endotoxamia. There is no effctive medication for endotoxaemia in clinical application. Hemoperfusion with Polymyixin B immobilized polystyrene microbeads can remove endotoxin of blood and improve hemorheology. Thus, polymyxin B immobilized polystyrene microbeads have a bright future in emergency trearment.
出处
《重庆大学学报（自然科学版）》
EI
CAS
CSCD
北大核心
2004年第6期51-54,共4页
Journal of Chongqing University
基金
重庆市科技计划资助项目(66138)
云南省省院省校科技合作资助项目(22154)
