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拉米夫定联合干扰素抗乙肝病毒疗效观察

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摘要 目的 :了解拉米夫定联合干扰素抗乙肝病毒的疗效。方法 :48例慢性乙型肝炎患者随机分组给予拉米夫定单独或联合干扰素治疗 ,疗程 1年 ,将血清 HBV- DNA、HBe Ag抗 HBe血清转换和 ALT水平等作为评价抗病毒疗效的指标。结果 :单用拉米夫定组 ( A组 ) HBe Ag转阴率1 8.75 % ,HBV- DNA转阴率 93.75 % ;拉米夫定联合干扰素组 ( B组 ) HBe Ag转阴率 5 0 % ,HBV-DNA转阴率 93.75 % ;单用干扰素组 ( C组 ) HBe Ag转阴率 31 .2 5 % ,HBV- DNA转阴率 75 %。无统计学差异 ( P>0 .0 5 )。结论 :B组可协同阻断乙肝病毒复制 ,提高抗乙肝病毒的疗效 ,但 HBV- DNA与 HBe Ag的转阴率无明显提高。
作者 金若珏
出处 《浙江中西医结合杂志》 2004年第5期281-282,共2页 Zhejiang Journal of Integrated Traditional Chinese and Western Medicine
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