摘要
目的 分析新生儿 O、 A、 B型血型与孕妇血型抗体效价的关系 ,了解能否用血型抗体效价≥ 1:5 12来预测新生儿 ABO溶血的严重程度。 方法 35 4例孕妇为 O型血型、丈夫为 A、B、 AB型血型 ,孕妇分娩时测定抗体效价 ,分娩后立即采集脐血做新生儿溶血病检测。 结果 新生儿血型不论是 A型、 B型 ,还是 O型 ,母亲血液中均可以检出抗 A或抗 B抗体 ,O型组新生儿与A、 B型组新生儿中母亲 Ig G抗 A或抗 B抗体效价分布不同 ,差异无显著性 (P>0 .0 5 )。新生儿 ABO溶血的发生率与母亲抗体效价相关 ,效价越高 ,新生儿 ABO溶血发生率越高 ,差异有显著性 (P<0 .0 5 ) ,但母亲抗体效价与新生儿溶血性贫血的发生率不相关。 结论 母亲血型免疫抗体效价的高低与新生儿血型有关 ,血型抗体效价≥ 1:5 12不能作为新生儿
Objective To investigate the relationship between O、A and B blood type of newborn and blood group antibody titer in pregnant women,and whether the fetal hemolytic status would be predicted by the blood group antibody titer when antibody titer was more than 1∶512 in blood group incompatibility. Methods We retrospectively analyzed the data of 354 pregnant women with blood group O and their husbands with blood group A,B,or AB.The serologic test of hemolytic disease of newborn was performed immediately after delivery in umbilical and mothers blood sample. Results Anti A or anti B IgG antibodies could be examined despite newborn was O、A or B blood type.Anti A or anti B IgG antibody titer of mothers hadn't significant difference between O and A,B blood group of newborn.The rate of ABO hemolytic disease of newborn was positive correlation with mothers antibody titer.But the rate of hemolytic anemia of newborn did not increase when the antibody titer was more than 1∶512. Conclusions The immune antibody titer of pregnant women can be independent of newborn blood type,and the antibody titer more than 1∶512 can also not be used to predict the severity of ABO hemolytic disease of newborn.
出处
《中国生育健康杂志》
2004年第1期25-27,共3页
Chinese Journal of Reproductive Health
