摘要
目的 :分析慢性肾衰竭行维持性血液透析患者的甲状腺激素变化及与中医证候的关系 ,以指导辨证分型 ,并探讨其机制。方法 :以 6 0例维持性血液透析患者为观察对象 ,测定其甲状腺激素 (TT3、TT4 、FT3、FT4 )和促甲状腺激素 (TSH) ,观察血液透析次数对甲状腺激素的影响 ,同时对临床症状进行分析归纳 ,找出甲状腺激素水平变化与中医证候分型的关系。结果 :每周 3次血液透析组 TT3、FT3与不足 3次组比较有显著性差异(P均 <0 .0 5 ) ;偏阳 (气 )虚组和偏阴 (血 )虚组的 TT3、FT3、TT4 、FT4 与正常组比较均有显著性差异 (P均 <0 .0 5 ) ;虚实错杂组 TT3、FT3与正常组比较有显著性差异 (P均 <0 .0 5 ) ;偏阳 (气 )虚组与偏阴 (血 )虚组、虚实错杂组 TT3、FT3、TT4 、FT4 比较有显著性差异 (P均 <0 .0 5 ) ;偏实证组 TT3、FT3、TT4 、FT4 与正常组比较无显著性差异 (P均 >0 .0 5 )。结论 :甲状腺激素与人体疾病虚实存在内在联系 ,其水平高低可为临床辨证施治用药提供一个量化指标 ;充分的血液透析治疗对改善继发性甲状腺功能减退有帮助。
Objective:To analyse the relationship between alteration of thyroid hormone and syndrome of traditional Chinese medicine(TCM) in patients on maintenance hemodialysis(HD) to guide syndrome differentiation and typing, and to investigate its mechanisms. Methods: Total triiodothyronine(TT 3), total thyroxine(TT 4), free triiodothyronine(FT 3), free thyroxine(FT 4) and thyroidstimulating hormone(TSH) of 60 cases who were on HD were detected. Influence of HD frequency on thyroid hormone was observed. Clinical symptoms were analysed to find relationship between alteration of thyroid hormone and syndrome of TCM. Results: TT 3 and FT 3 had significant differences in the group treated three times every week in comparison with the group less than three times(P<0.05). TT 3, TT 4, FT 3, FT 4 both in group of deficiency of Yang(Qi)〔偏阳(气)虚〕and group of deficiency of Yin(blood)〔偏阴(血)虚〕 had significant differences in comparison with normal group (all P<0.05). TT 3, FT 3 in group of deficiency and excess(虚实错杂) had significant differences in comparison with normal group (both P<0.05). TT 3, TT 4, FT 3, FT 4 in group of deficiency of Yang(Qi) had significant differences in comparison with both group of deficiency of Yin(blood) and group of deficiency and excess(all P<0.05). TT 3, TT 4, FT 3, FT 4 in the group of excess had not significant differences in comparison with normal group(all P>0.05). Conclusion: Thyroid hormone has relationship with deficiency and excess of body. Level of thyroid hormone can be regarded as index for guiding syndrome differentiation and typing, treatment or so. There is high meaning for improving malnutrition and reducing death rate. HD fully is favourable to improving secondary hypothyroidism.
出处
《中国中西医结合急救杂志》
CAS
2003年第6期343-345,共3页
Chinese Journal of Integrated Traditional and Western Medicine in Intensive and Critical Care
基金
广东省中山市科研立项课题资助项目 ( 2 0 0 2 5 616)
