摘要
^(99)Tc^m-ECD在诊断脑部疾患方面是一种有价值的新型脑灌注显像剂。^(99)Tc^m-ECD通过配体交换方法制备。研究了^(99)Tc^m-GH与ECD之间的配体交换反应时介质的pH值、ECD的浓度、GH的浓度对^(99)Tc^m-GH与ECD进行配体交换反应的影响。结果表明,pH值、ECD的浓度对配体交换反应的影响较显著;并计算了不同pH值的反应速度常数。
The complex ^(99)Te^m-ethyl cysteinate dimer (^(99)Tc^m-ECD) which is a valuable brain imaging agent is prepared through the ligand exchange reaction between ^(99)Tc^m-glucoheptonate (GH) and ECD. In order to explore the exchange reaction between the ^(99)Tc^m-GH and N_2S_2 type ligands as a common methodfor the preparation of ^(99)Tc^m-N_2S_2 complexes, the ligand exchange reaction between ^(99)Tc^m-GH and ECD was studies at different pH values, reaction time, ECD and Na-GH concentrations. The exchange ratio was determined by paper chromatography, and the reaction rate constants were calculated at different ECD concentration (pH=6) and different pH values. The results obtained show that the ligand exchange between ^(99)Tc^m-GH and ECD is a second order reaction and the rate constant of the ligand exchange reaction depends on pH values.
出处
《同位素》
CAS
北大核心
1992年第1期15-19,共5页
Journal of Isotopes
关键词
葡庚糖酸钠
配体交换
反应速度
ECD
^(99)Tc^m-glucoheptonate (^(99)Tc^m-GH), ^(99)Tc^m-ethyl cysteinate dimer (^(99)Tc^m-ECD), ligand exchange reaction rate constant.
