摘要
目的 探讨诱导型一氧化氮合酶(inducible nitric oxide synthase,iNOS)在慢性鼻窦炎鼻息肉嗅觉障碍发病过程中的作用。方法 30例慢性鼻窦炎嗅觉障碍病人经临床分型分期,行嗅觉功能检查后,取嗅粘膜标本,行iNOS的免疫组化染色,光镜观察。结果 慢性鼻窦炎鼻息肉2型2,3期和3型的嗅粘膜中iNOS的表达显著高于1型和2型1期(P<0.05)。并与嗅觉障碍的严重程度呈正相关。结论 iNOS可能参与了慢性鼻窦炎所致嗅觉障碍的嗅觉损害过程,损害程度与慢性耳窦炎鼻息肉的临床分型分期有关。
Objective To study the expression and significance of inducible nitric oxide synthase(iNOS) in olfactory mucosa of chronic sinusitis dysosmia. Methods Thirty patients with chronic sinusitis were divided into two groups: group A(representing type land type 2 phase 1) and group B(representing type 2 phase 2 - 3 and type 3). Expression of iNOS in olfactory mucosa in both groups was prospectively studied with immunohistochemistry after olfactory examination. Tissue sections were observed under optical microscope. Results The iNOS positivity in olfactory mucosa and Bowman glandular cell in group A was significantly higher than that in group B ( P < 0.05). The expression of iNOS was correlated to the degree of dysosmia ( P < 0.05). Conclusion iNOS may contribute to dysosmia by chronic sinusitis, correlated to its clinical typing and phasing.
出处
《中国耳鼻咽喉颅底外科杂志》
CAS
2003年第4期217-219,T001,共4页
Chinese Journal of Otorhinolaryngology-skull Base Surgery
基金
福建省教育厅资助课题(99A035)
