摘要
目的 :研究复方冬虫夏草多糖脂质体口服液对慢性乙型肝炎的疗效。方法 :应用脂质体包裹虫草多糖、黄芪、丹参制成口服液 ,治疗慢性乙型肝炎 5 2例并与 4 0例一般保肝药物治疗患者进行对照。结果 :治疗 3个月后 ,治疗组与对照组ALT复常率分别是 6 5 .4 %和 4 2 .5 % (P <0 .0 5 ) ,HBeAg阴转率分别为 34.6 %和 2 .5 % (P <0 .0 1) ,HBV DNA阴转率分别为4 2 .3%和 5 % (P <0 .0 1) ,治疗前后血清透明质酸、Ⅳ型胶原、层粘蛋白治疗组均明显下降 (P <0 .0 1)对照组无显著变化 (P >0 .0 5 )。结论 :复方虫草多糖脂质体口服液治疗慢性乙型肝炎对改善肝功能、抗病毒及抗纤维化具有良好的效果。
Objective: To study the therapeutic effects of compound Cordyceps sinensis liposome oral liquid in treatment of chronic hepatitis B. Method: The tested group(52 cases) was given the liposome oral liquid containing cordyceps sinensis, Astragali L and Salvia miltiorrhiza , the controlled group(40 cases) was given the other ordinary drugs of protecting liver.Result: Three months after the treatment, the rate of serum ALT back to normal in the tested group was 65.4% , the controlled group was 42.5% ( P < 0.05 ). The negative conversion rate of serum HBeAg were 65.4% and 42.5% , respectively( P < 0.05 ); the negative conversion rate of HBeAg were 34.6% and 2.5% , respectively( P < 0.001 ); the negative conversion rate of HBV DNA were 42.3% and 5%, respectively ( P < 0.001 ). Before and after therapy, the level declining of serum HA, IV C, LN had markedly difference in the tested group ( P < 0.01 ), but there was no significant difference in the controlled group ( P > 0.05% ). Conclusion: The compound Cordyceps sinensis liposome oral liquid has a good curative effect on chronic hepatitis B, it can improve the liver function, resist virus, and prevent liver fibrosis.
出处
《中国药师》
CAS
2003年第7期438-439,共2页
China Pharmacist
关键词
乙型肝炎
慢性
冬虫夏草
脂质体
中药疗法
Chronic hepatitis B
Cordyceps sinensis
Liposomes
Therapy,TCM
