摘要
野木瓜注射液可阻滞神经传导和解髓鞘,在临床上有显著的镇痛作用,通过有效成分的分离、提取和初步药理研究,发现其中皂甙有神经传导阻滞作用。神经干外敷0.3％皂甙后,60min起效,使大鼠隐神经复合动作电位A成分下降为给药前的0.22±0.28(n=5),80min时为0.03±0.05,P<0.001。
Stauntonia chinensis DC is a medicinal herb used for relieving the pain. Its injection (Injection Stauntoniae, IS) is applied as an analgesic clinically in China. It functions to block nerve conduction and causes demyelination. After extraction, 0. 3% saponin was prepared and applied on the saphenous nerve of SD rats. Sixty minutes after application, the amplitude of A component of the compound action potentials dropped to 0. 22+0. 28 ( n = 5 ) of the control ( P < 0. 001). The saponin in Stauntonia chinensis DC may play an effect of analgia.
出处
《上海师范大学学报（自然科学版）》
2002年第4期71-74,共4页
Journal of Shanghai Normal University(Natural Sciences)
基金
上海市高校科技发展基金(CL200012)
