摘要
Chip-scale micro-photonic biosensors have made significant advancements over the past two decades,with various platforms developed for detecting biomarkers,such as proteins in biological fluids.The influenza virus pandemic has notably accelerated research in bio-detection,driving the development of many high-performance sensors.Despite these advancements,there remains a pressing need for technical solutions that offer point-of-care features,including low cost,rapid response,and low limit of detection(LOD).This study investigates the reflective micro-ring resonator(RMRR) cascaded with a loop mirror.By incorporating a loop mirror into the through port of the micro-ring resonator(MRR),the resonant light is reflected back into the micro-ring and interacts with the analyte again,thereby reducing the LOD of the ring resonator sensor.Experimental results show that the LOD of the MRR sensor is 1.2 × 10^(-5)RIU,while the LOD of the RMRR sensor is3.8 × 10^(-6)RIU.After functionalizing the waveguide surface of the ring resonator,the RMRR can detect the alpha-fetoprotein(AFP) molecules with a sensitivity of 0.24 pm/(ng/mL) and an LOD of 3.1 ng/mL.This silicon-based optoelectronic on-chip RMRR shows great potential in the field of biomedical molecular detection.
基金
supported by the National Key R&D Program of China (No.2022YFB2901001)
the Science and Technology Program of Zhejiang Province (No.2022C01108)。
