摘要
The synthesis of nanoparticles of conjugates of caffeic acid-modified chitosan with ruthenium arene complexes is described.The chemical structure and physical properties of the nanoparticles were characterised by electronic absorption spectroscopy(UV-vis),Fourier transform infrared spectroscopy(FT-IR),1H NMR spectroscopy,dynamic light scattering(DLS),transmission electron microscopy(TEM),X-ray powder diffraction(XRD),and circular dichroism(CD)analysis.The multi-spectral results revealed that caffeic acid is covalently bound to chitosan and chelates to{Ru(p-cymene)Cl}+.The DLS studies indicated that the Ru-caffeic acid modified chitosan nanoparticles are well-defined and of nanometre size.Such well-defined nanocomposites of chitosan and metal complexes might find a range of applications,for example in drug delivery.
基金
the National Natural Science Foundation of China(Project No.21571154)
the Jiangsu Overseas Research&Training Program for University Prominent Young&Middle-aged Teachers and Presidents,Leverhulme Trust(Early Career Fellowship No.ECF-2013-414 to NPEB)
the ERC(Grant No.247450 to PJS)
EPSRC(EP/F034210/1 to PJS)
Science City(AWM/ERDF)for support,and EU COST Action CM1105 for stimulating discussions.
