摘要
Ulcerative colitis(UC)is a chronic,recurring gastrointestinal disease that not only threatens human health but also increases the risk of colon cancer.Camellia oil has potential for the treatment of colitis.However,bioactive compounds,namely squalene andα-tocopherol,vary greatly in Camellia oil from different regions,and their therapeutic efficacy in colitis varies.We therefore investigated the effect of Camellia oil with different concentrations of squalene andα-tocopherol on colitis.Our results showed that Camellia oil attenuated the weight loss,decreased disease activity index(DAI),increased colon length,improved colon histology in DSS-induced colitis in mice,and reduced the gene expression and serum concentrations of TNF-αand IL-6.Camellia oil supplemented with squalene(final concentration of 375 mg/kg of Camellia oil)andα-tocopherol(final concentration of 600 mg/kg of Camellia oil)had the most potent effects on the alleviation of colitis symptoms.In conclusion,the intake of Camellia oil relieved DSS-induced colitis,and the modulation of squalene andα-tocopherol contents in Camellia oil further impacted its efficacy,which provides a theoretical basis for the development of novel Camellia oil with potent therapeutic potential to lower the risk of colitis.
基金
supported by“Shuangqian Project“of Jiangxi Province(Grant No.jxsq2020101063)
Xinghuo Biotechnology Co.,Ltd.(Jiangxi,China).
