摘要
目的:分析血清胎盘蛋白-13(PP13)/D-二聚体(D-D)、缺血修饰白蛋白与白蛋白比值(IMAR)在子痫前期(PE)患者中表达和临床意义。方法:选择2021年2月—2024年6月我院收治的PE患者215例作为研究对象,根据不同妊娠结局分为不良组(n=60)和良好组(n=155),采用倾向评分匹配(PSM)法匹配2组患者基线资料。统计2组患者PSM前后基线资料,比较2组患者PP13/D-D、IMAR、PE综合风险评估系统(FullPIERS)评分,比较不同病情PE患者PP13/D-D、IMAR、FullPIERS评分,分析PP13/D-D、IMAR和FullPIERS评分对PE患者妊娠结局的影响,并比较不同方案预测PE妊娠结局的价值。结果:不良组患者PP13/D-D低于良好组患者,IMAR、FullPIERS评分高于良好组患者(P<0.05);重度患者PP13/D-D低于非重度患者,IMAR、FullPIERS评分高于非重度患者(P<0.05);多因素Logistic回归分析,PP13/D-D、IMAR和FullPIERS评分是PE患者妊娠结局的相关影响因素(P<0.05);FullPIERS评分、PP13/D-D、IMAR、PP13/D-D+IMAR预测PE妊娠结局的曲线下面积(AUC)分别为0.75、0.77、0.76、0.91,其中PP13/D-D+IMAR预测的AUC明显优于FullPIERS评分、PP13/D-D、IMAR单独预测的AUC。结论:PP13/D-D、IMAR和PE患者病情、妊娠结局密切相关,PP13/D-D、IMAR可用于辅助评估患者妊娠结局。
Objective:To analyze the expression and clinical significance of serum placental protein-13(PP13)/D-dimer(D-D)and ischemia-modified albumin to albumin ratio(IMAR)in patients with preeclampsia(PE).Methods:A total of 215 patients with PE admitted to our hospital from February 2021 to June 2024 were selected and categorized into an adverse outcome group and a favorable outcome group based on different pregnancy outcomes.The propensity score matching(PSM)method was used to match the baseline data of the two groups.Baseline data,PP13/D-D,IMAR,and FullPIERS(Full Pilot Evaluation of Risk in Early Pregnancy)scores were compared between the two groups before and after PSM.These indicators were also compared among patients with different degrees of PE.The impact of PP13/D-D,IMAR,and FullPIERS scores on the pregnancy outcomes of PE was analyzed,and the value of different schemes in predicting the pregnancy outcomes of PE was compared.Results:The PP13/D-D ratio in the adverse outcome group was lower than that in the favorable outcome group,while the IMAR and FullPIERS scores were higher(P<0.05).The PP13/D-D ratio in severe patients was lower than that in non-severe patients,while the IMAR and FullPIERS scores were higher(P<0.05).Multivariate Logistic regression analysis showed that PP13/D-D,IMAR,and FullPIERS scores were the relevant influencing factors for PE pregnancy outcomes(P<0.05).The areas under the ROC curve(AUC)for FullPIERS score,PP13/D-D,IMAR,and PP13/D-D+IMAR in predicting the pregnancy outcome of PE were 0.75,0.77,0.76,and 0.91,respectively.Notably,the predictive AUC of PP13/D-D+IMAR was significantly better than that of FullPIERS score,PP13/D-D,and IMAR alone.Conclusion:PP13/D-D and IMAR are closely related to the condition and pregnancy outcomes of PE patients,and can be used to assist in evaluating the pregnancy outcomes of patients.
作者
李明巧
孙屹梅
郭伟
马月蓉
LI Mingqiao;SUN Yimei;GUO Wei;MA Yuerong(Department of First Obstetrics,Hengshui Second People's Hospital,Hengshui,Hebei Province,053000)
出处
《中国计划生育学杂志》
2026年第4期916-922,995,共8页
Chinese Journal of Family Planning
基金
衡水市科技计划项目(2022014052Z)。
