摘要
Catechins,phenolic compounds renowned for their superior antioxidant and metal chelating attributes,are commonly found in foods.Cadmium(Cd)is a highly toxic heavy metal especially detrimental to the liver.However,the potential toxicologic effects of catechins against Cd-induced hepatotoxicity remains poorly studied.To investigate the preventive effects of catechins on Cd exposure,adult C57/BL6J mice were employed,receiving 100 mg/kg body weight(BW)catechins for consecutive 14 days by gavage,followed by acute exposure to 20 mg/kg BW Cd on the final day.Focusing on the liver,our findings demonstrated that catechins effectively alleviated Cd-induced hepatoxicity,including the hepatic Cd accumulation,transaminases levels in serum,inflammation and oxidative stress in the liver.By using brusatol,a Nrf2 inhibitor,the prevention of catechins was reversed,highlighting the crucial key to Kelch-like ECH-associated protein 1(Keap1)-Nuclear factor erythroid 2-related factor 2(Nrf2)pathway in counteracting Cd-induced hepatoxicity.Our results revealed the beneficial effect of catechins on alleviating Cd-induced hepatotoxicity through the Keap1-Nrf2 pathway,and also provided a novel insight into the beneficial properties of catechins to counteract metal toxicity.
基金
supported by the Research Foundation from Academic and Technical Leaders of Major Disciplines in Jiangxi Province,China(20194BCJ22004).
