摘要
This study aimed to investigate the effects of monosodium glutamate(MSG)on immune function in the context of high-fat diet(HFD),and to evaluate the immunomodulatory effects of myricetin(MYR)on MSG-induced immune dysfunction in a HFD lifestyle.Our results indicated that MSG exacerbated immune dysfunction and immune dysfunction related complications in HFD mice,primarily manifested as increased obesity,hyperglycemia,dyslipidemia,abnormal inflammation,congenital and adaptive immune dysfunction.However,MYR significantly alleviated the immune dysfunction and immune dysfunction related complications caused by consuming MSG in the context of HFD.At the gut microbiota level,MYR significantly diminished the abundance of proinflammatory bacteria such as Alistipes and Desulfovibrio,and augmented the abundance of immune-enhancing beneficial bacteria such as Lactobacillus,Bacteroidetes,Roseburia,and Faecalibaculum.Additionally,MYR significantly increased the levels of short chain fatty acids(SCFAs),including acetic acid,propionic acid,and butyric acid.Interestingly,Pearson correlation analysis showed a significant correlation between these SCFAs and immune related indicators especially CD3^(+)T cell in the lymph.The potential immune regulatory mechanism of MYR in this study may be attributed to its capability to target the gut microbiota and enhance the production of SCFAs.Overall,MYR showed great potential in improving immune dysfunction and was anticipated to become a novel therapeutic agent for treating immune-related diseases in the future.
基金
supported by Juan de la Cierva-formación 2020(IJC2020-046055-I)
Ramón y Cajal grant(RYC2020-030365-I)
Xunta de Galicia for supporting the program(Excelencia-ED431F2022/01)
Natural Science Foundation of Hunan Province(2024JJ6277).
