摘要
Edible bird’s nest is rich in protein and have been treasured for centuries for its health benefits such as antioxidant,immunomodulation,and skin-beneficial.The research aimed to validate the in vivo wound healing bioactivity of edible bird’s nest derived peptides(EBNP)as a nutritional supplementation.Structural characterization showed that EBNP had high homogeneity,average amino acid profile,low molecular weight,and compacted three-dimensional conformation of over 80%α-helical structure.Moreover,hydrophobic peptides and single amino acid repeats were found abundantly in EBNP complex,which could be an indication of the skin repairing peptides.As a result of the in vivo validation,EBNP showed higher skin-repairing activity than sialic acid and glutathione,improved the wound healing rate to 86.77%after 8 days of recovery,and resulted in a greater dermis collagen ratio of 30.33%.The research investigated the structural basis,and found dietary peptides as the primary skin-repairing bioactive compounds in EBNP,which enabled EBNP a potential nutritional supplementation for wound-healing.
基金
National Key R&D Program of China(2023YFF1104004)
the National Key R&D Program of China(2024YFE0104900)
the Guangdong Basic and Applied Basic Research Foundation(2023B1515040029)
the National Natural Sci-ence Foundation of China(32202017)
the Major Science and Technology Projects in the Xinjiang Uygur Autonomous Region(2022A02004)for their financial support.
